Showing entry for [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013542
Protein Name[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial
Uniport IdQ15120
GenePDK3
Gene Id5165
DomainBCDHK_Adom3; HATPase_c
Pfam PF10436   PF02518  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071398 cellular response to fatty acid
Biological Process GO:0071333 cellular response to glucose stimulus
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0006006 glucose metabolic process
Biological Process GO:0097411 hypoxia-inducible factor-1alpha signaling pathway
Biological Process GO:1904183 negative regulation of pyruvate dehydrogenase activity
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0035357 peroxisome proliferator activated receptor signaling pathway
Biological Process GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate
Biological Process GO:0010906 regulation of glucose metabolic process
Biological Process GO:2000377 regulation of reactive oxygen species metabolic process
molecular function GO:0005524 ATP binding
molecular function GO:0004672 protein kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005739 mitochondrion
cellular component GO:0005730 nucleolus
Reactome
Pathway Id Pathway Name
R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction
R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex
R-HSA-5362517 Signaling by Retinoic Acid
R-HSA-70268 Pyruvate metabolism
R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle
R-HSA-9006931 Signaling by Nuclear Receptors
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007959 BXGD000507 Charcot-Marie-Tooth Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0016977 BXGD001086 Gall Bladder Diseases Digestive System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020580 BXGD001435 Hypesthesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0023448 BXGD001649 Lymphoid leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039273 BXGD002806 Talipes cavus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152025 BXGD003521 Polyneuropathy Nervous System Diseases
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0239831 BXGD004999 Hand muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0239842 BXGD005001 Tremor of hands
C0241005 BXGD005072 Creatine phosphokinase serum increased
C0270921 BXGD006133 Axonal neuropathy Nervous System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0311394 BXGD006884 Difficulty walking Pathological Conditions, Signs and Symptoms
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0427149 BXGD008608 Gait, Drop Foot Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0558845 BXGD009459 Reflex, Ankle, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C1112256 BXGD011655 Sensorimotor neuropathy
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1334978 BXGD012753 Non-Hereditary Clear Cell Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1836296 BXGD014105 Muscle Weakness Lower Limb Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836451 BXGD014118 Distal lower limb amyotrophy
C1847584 BXGD014876 Distal sensory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1847879 BXGD014895 X-linked dominant inheritance
C1849134 BXGD015010 Impaired vibration sensation in the lower limbs
C1854301 BXGD015391 Motor delay Mental Disorders
C1854494 BXGD015409 Slow progression
C1857640 BXGD015726 Decreased nerve conduction velocity
C1864715 BXGD016244 Thenar muscle atrophy
C3275124 BXGD018660 Biliary System Disorder
C3806702 BXGD019524 CHARCOT-MARIE-TOOTH DISEASE, X-LINKED DOMINANT, 6
C4025609 BXGD021691 EMG: axonal abnormality
C4706411 BXGD023692 X-linked Charcot-Marie-Tooth disease type 6
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002588 Magnesium 24.31
BXGC0002591 Potassium 39.1
BXGC0028613 abietyl alcohol 288.25
BXGC0037224 Dichloroacetic Acid 127.94
BXGC0041564 Abietic Acid 302.22
BXGC0048229 [(1R,4As,10Ar)-1,4A-Dimethyl-7-Propan-2-Yl-2,3,4,9,10,10A-Hexahydrophenanthren-1-Yl]Methanamine 285.25
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein