adisease

Showing entry for Lymphoid leukemia

General Disease Information
BXGD Id	BXGD001649
Disease Name	Lymphoid leukemia
Disease CUI Id	C0023448
MeSH Codes	C04 C20 C15
Disease Class Name	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
Semantic Type	Neoplastic Process
Human Phenotype Ontology Id	HP:0002715 HP:0002664 HP:0001871
Human Phenotype Ontology Term	Abnormality of the immune system; Neoplasm; Abnormality of blood and blood-forming tissues
Disease Ontology Id	DOID:7 DOID:14566
Disease Ontology Class Name	disease of anatomical entity; disease of cellular proliferation
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O14744	BXGT004089	Protein arginine N-methyltransferase 5	10419	reviewed	Epigenetic regulator
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O14939	BXGT004115	Phospholipase D2	5338	reviewed
O43255	BXGT004579	E3 ubiquitin-protein ligase SIAH2	6478	reviewed
O43318	BXGT004586	Mitogen-activated protein kinase kinase kinase 7	6885	reviewed	Kinase
O43524	BXGT004599	Forkhead box protein O3	2309	reviewed
O43683	BXGT004614	Mitotic checkpoint serine/threonine-protein kinase BUB1	699	reviewed	Kinase
O60674	BXGT004892	Tyrosine-protein kinase JAK2	3717	reviewed	Kinase
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O60858	BXGT004903	E3 ubiquitin-protein ligase TRIM13	10206	reviewed
O95749	BXGT005394	Geranylgeranyl pyrophosphate synthase	9453	reviewed
P00519	BXGT005570	Tyrosine-protein kinase ABL1	25	reviewed	Kinase
P00750	BXGT005642	Tissue-type plasminogen activator	5327	reviewed	Enzyme
P01024	BXGT005719	Complement C3	718	reviewed	Enzyme modulator
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01111	BXGT005731	GTPase NRas	4893	reviewed	Enzyme modulator
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01574	BXGT005768	Interferon beta	3456	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01589	BXGT005773	Interleukin-2 receptor subunit alpha	3559	reviewed	Receptor
P04150	BXGT006154	Glucocorticoid receptor	2908	reviewed	Nuclear receptor
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P05109	BXGT006318	Protein S100-A8	6279	reviewed	Calcium-binding protein
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06239	BXGT006427	Tyrosine-protein kinase Lck	3932	reviewed	Kinase
P06730	BXGT006487	Eukaryotic translation initiation factor 4E	1977	reviewed	Nucleic acid binding
P06734	BXGT006491	Low affinity immunoglobulin epsilon Fc receptor	2208	reviewed	Receptor
P06748	BXGT006497	Nucleophosmin	4869	reviewed	Chaperone
P07332	BXGT006601	Tyrosine-protein kinase Fes/Fps	2242	reviewed	Kinase
P07333	BXGT006602	Macrophage colony-stimulating factor 1 receptor	1436	reviewed	Kinase
P07900	BXGT006696	Heat shock protein HSP 90-alpha	3320	reviewed	Chaperone
P07948	BXGT006702	Tyrosine-protein kinase Lyn	4067	reviewed	Kinase
P08069	BXGT006723	Insulin-like growth factor 1 receptor	3480	reviewed	Kinase
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08185	BXGT006742	Corticosteroid-binding globulin	866	reviewed	Enzyme modulator
P08311	BXGT006762	Cathepsin G	1511	reviewed	Enzyme
P08473	BXGT006773	Neprilysin	4311	reviewed	Enzyme
P08575	BXGT006793	Receptor-type tyrosine-protein phosphatase C	5788	reviewed	Enzyme
P08700	BXGT006816	Interleukin-3	3562	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10644	BXGT007597	cAMP-dependent protein kinase type I-alpha regulatory subunit	5573	reviewed
P10721	BXGT007605	Mast/stem cell growth factor receptor Kit	3815	reviewed	Kinase
P11215	BXGT007672	Integrin alpha-M	3684	reviewed
P11274	BXGT007681	Breakpoint cluster region protein	613	reviewed	Enzyme modulator
P11308	BXGT007684	Transcriptional regulator ERG	2078	reviewed	Transcription factor
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P11926	BXGT007760	Ornithine decarboxylase	4953	reviewed	Enzyme
P13612	BXGT007928	Integrin alpha-4	3676	reviewed
P13688	BXGT007943	Carcinoembryonic antigen-related cell adhesion molecule 1	634	reviewed
P14324	BXGT008005	Farnesyl pyrophosphate synthase	2224	reviewed	Enzyme
P14921	BXGT008068	Protein C-ets-1	2113	reviewed	Transcription factor
P15144	BXGT008087	Aminopeptidase N	290	reviewed	Enzyme
P16070	BXGT008186	CD44 antigen	960	reviewed
P16234	BXGT008209	Platelet-derived growth factor receptor alpha	5156	reviewed	Kinase
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P16671	BXGT008255	Platelet glycoprotein 4	948	reviewed	Receptor
P19525	BXGT008492	Interferon-induced, double-stranded RNA-activated protein kinase	5610	reviewed	Kinase
P19544	BXGT008494	Wilms tumor protein	7490	reviewed	Nucleic acid binding
P20273	BXGT008557	B-cell receptor CD22	933	reviewed
P21709	BXGT008685	Ephrin type-A receptor 1	2041	reviewed	Kinase
P24158	BXGT008951	Myeloblastin	5657	reviewed	Enzyme
P24941	BXGT009002	Cyclin-dependent kinase 2	1017	reviewed	Kinase
P25791	BXGT009072	Rhombotin-2	4005	reviewed
P25942	BXGT009079	Tumor necrosis factor receptor superfamily member 5	958	reviewed
P26951	BXGT009147	Interleukin-3 receptor subunit alpha	3563	reviewed	Signaling
P27361	BXGT009176	Mitogen-activated protein kinase 3	5595	reviewed	Kinase
P28072	BXGT009231	Proteasome subunit beta type-6	5694	reviewed
P28907	BXGT009301	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	952	reviewed	Enzyme
P29320	BXGT009332	Ephrin type-A receptor 3	2042	reviewed	Kinase
P29597	BXGT009367	Non-receptor tyrosine-protein kinase TYK2	7297	reviewed	Kinase
P30530	BXGT009431	Tyrosine-protein kinase receptor UFO	558	reviewed	Kinase
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P36888	BXGT009938	Receptor-type tyrosine-protein kinase FLT3	2322	reviewed	Kinase
P39060	BXGT010088	Collagen alpha-1(XVIII) chain	80781	reviewed
P40692	BXGT010195	DNA mismatch repair protein Mlh1	4292	reviewed	Nucleic acid binding
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P40933	BXGT010209	Interleukin-15	3600	reviewed
P41180	BXGT010230	Extracellular calcium-sensing receptor	846	reviewed	G-protein coupled receptor
P41182	BXGT010231	B-cell lymphoma 6 protein	604	reviewed
P41212	BXGT010235	Transcription factor ETV6	2120	reviewed	Transcription factor
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P43403	BXGT010385	Tyrosine-protein kinase ZAP-70	7535	reviewed	Kinase
P43405	BXGT010386	Tyrosine-protein kinase SYK	6850	reviewed	Kinase
P45381	BXGT010460	Aspartoacylase	443	reviewed
P46531	BXGT010526	Neurogenic locus notch homolog protein 1	4851	reviewed
P48061	BXGT010616	Stromal cell-derived factor 1	6387	reviewed
P49902	BXGT010758	Cytosolic purine 5'-nucleotidase	22978	reviewed	Enzyme
P51580	BXGT010864	Thiopurine S-methyltransferase	7172	reviewed
P51692	BXGT010885	Signal transducer and activator of transcription 5B	6777	reviewed	Nucleic acid binding
P52701	BXGT010943	DNA mismatch repair protein Msh6	2956	reviewed	Nucleic acid binding
P55789	BXGT011126	FAD-linked sulfhydryl oxidase ALR	2671	reviewed	Enzyme
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P62993	BXGT011480	Growth factor receptor-bound protein 2	2885	reviewed
P78310	BXGT011830	Coxsackievirus and adenovirus receptor	1525	reviewed
Q00987	BXGT012559	E3 ubiquitin-protein ligase Mdm2	4193	reviewed	Nucleic acid binding
Q01094	BXGT012568	Transcription factor E2F1	1869	reviewed	Nucleic acid binding
Q01196	BXGT012575	Runt-related transcription factor 1	861	reviewed	Transcription factor
Q02750	BXGT012662	Dual specificity mitogen-activated protein kinase kinase 1	5604	reviewed	Kinase
Q03164	BXGT012700	Histone-lysine N-methyltransferase 2A	4297	reviewed
Q04721	BXGT012777	Neurogenic locus notch homolog protein 2	4853	reviewed
Q06124	BXGT012856	Tyrosine-protein phosphatase non-receptor type 11	5781	reviewed
Q06187	BXGT012860	Tyrosine-protein kinase BTK	695	reviewed	Kinase
Q07869	BXGT012945	Peroxisome proliferator-activated receptor alpha	5465	reviewed	Nuclear receptor
Q09428	BXGT013036	ATP-binding cassette sub-family C member 8	6833	reviewed	Transporter
Q12866	BXGT013273	Tyrosine-protein kinase Mer	10461	reviewed	Kinase
Q13126	BXGT013313	S-methyl-5'-thioadenosine phosphorylase	4507	reviewed	Enzyme
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q13625	BXGT013384	Apoptosis-stimulating of p53 protein 2	7159	reviewed	Enzyme modulator
Q14643	BXGT013493	Inositol 1,4,5-trisphosphate receptor type 1	3708	reviewed	Ion channel
Q14790	BXGT013505	Caspase-8	841	reviewed	Enzyme
Q14994	BXGT013519	Nuclear receptor subfamily 1 group I member 3	9970	reviewed	Nuclear receptor
Q15120	BXGT013542	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	5165	reviewed	Kinase
Q15125	BXGT013543	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	10682	reviewed	Enzyme
Q15910	BXGT013612	Histone-lysine N-methyltransferase EZH2	2146	reviewed	Epigenetic regulator
Q59FK2	BXGT015276	Selenocysteine lyase variant	51540	unreviewed
Q8NER1	BXGT018556	Transient receptor potential cation channel subfamily V member 1	7442	reviewed	Ion channel
Q96AZ6	BXGT019621	Interferon-stimulated gene 20 kDa protein	3669	reviewed
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96I15	BXGT019674	Selenocysteine lyase	51540	reviewed	Enzyme
Q96J66	BXGT019680	ATP-binding cassette sub-family C member 11	85320	reviewed	Transporter
Q96T88	BXGT019747	E3 ubiquitin-protein ligase UHRF1	29128	reviewed
Q9NR12	BXGT021174	PDZ and LIM domain protein 7	9260	reviewed	Cellular structure
Q9NR96	BXGT021181	Toll-like receptor 9	54106	reviewed
Q9NUX5	BXGT021220	Protection of telomeres protein 1	25913	reviewed	Nucleic acid binding
Q9NY59	BXGT021251	Sphingomyelin phosphodiesterase 3	55512	reviewed
Q9P2W7	BXGT021306	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1	27087	reviewed	Enzyme
Q9UJU2	BXGT021730	Lymphoid enhancer-binding factor 1	51176	reviewed
Q9UM47	BXGT021772	Neurogenic locus notch homolog protein 3	4854	reviewed
Q9UM73	BXGT021773	ALK tyrosine kinase receptor	238	reviewed	Kinase
Q9UPN9	BXGT021799	E3 ubiquitin-protein ligase TRIM33	51592	reviewed
Q9Y251	BXGT022215	Heparanase	10855	reviewed	Enzyme
Q9Y2Q3	BXGT022242	Glutathione S-transferase kappa 1	373156	reviewed
Q9Y5S1	BXGT022300	Transient receptor potential cation channel subfamily V member 2	51393	reviewed	Ion channel
O60936	BXGT022857	Nucleolar protein 3	8996	reviewed
Q13007	BXGT023883	Interleukin-24	11009	reviewed
P20809	BXGT025043	Interleukin-11	3589	reviewed
P31358	BXGT025061	CAMPATH-1 antigen	1043	reviewed
Q9UKB1	BXGT025928	F-box/WD repeat-containing protein 11	23291	reviewed
P11836	BXGT025994	B-lymphocyte antigen CD20	931	reviewed	Receptor
P62263	BXGT026033	40S ribosomal protein S14	6208	reviewed	Nucleic acid binding

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}