Showing entry for Rhodopsin kinase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013606
Protein NameRhodopsin kinase
Uniport IdQ15835
GeneGRK1
Gene Id6011
DomainPkinase; RGS
Pfam PF00069   PF00615  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04062 Chemokine signaling pathway
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
5. Organismal Systems 5.7 Sensory system hsa04744 Phototransduction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0008277 regulation of G protein-coupled receptor signaling pathway
Biological Process GO:0022400 regulation of rhodopsin mediated signaling pathway
Biological Process GO:0016056 rhodopsin mediated signaling pathway
Biological Process GO:0007601 visual perception
molecular function GO:0005524 ATP binding
molecular function GO:0004703 G protein-coupled receptor kinase activity
molecular function GO:0004672 protein kinase activity
molecular function GO:0050254 rhodopsin kinase activity
cellular component GO:0097381 photoreceptor disc membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-2187338 Visual phototransduction
R-HSA-2187338 Visual phototransduction
R-HSA-2514856 The phototransduction cascade
R-HSA-2514856 The phototransduction cascade
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-372790 Signaling by GPCR
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
R-HSA-418594 G alpha (i) signalling events
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014038 BXGD000878 Encephalitis Nervous System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028077 BXGD002069 Nyctalopia Eye Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0234632 BXGD004691 Reduced visual acuity Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0271183 BXGD006169 Severe myopia Eye Diseases
C0339535 BXGD007263 Night blindness, congenital stationary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1298695 BXGD012251 Hypoplasia of optic disc Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C1306122 BXGD012355 Oguchi disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1849394 BXGD015048 Enhanced S-Cone Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C1857743 BXGD015745 LEBER CONGENITAL AMAUROSIS 12 (disorder) Eye Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2931258 BXGD017991 Amaurosis congenita of Leber, type 1 Eye Diseases
C3150678 BXGD018321 OGUCHI DISEASE 2
C3551052 BXGD019144 Night blindness, stationary
C4024756 BXGD021405 Abnormality of macular pigmentation
C4551824 BXGD023412 Oguchi Disease 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein