Showing entry for Alpha-mannosidase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013660
Protein NameAlpha-mannosidase 2
Uniport IdQ16706
GeneMAN2A1
Gene Id4124
DomainAlpha-mann_mid; Glyco_hydro_38C; Glyco_hydro_38N
Pfam PF09261   PF07748   PF01074  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.7 Glycan biosynthesis and metabolism hsa00510 N-Glycan biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0001889 liver development
Biological Process GO:0048286 lung alveolus development
Biological Process GO:0006013 mannose metabolic process
Biological Process GO:0007005 mitochondrion organization
Biological Process GO:0006491 N-glycan processing
Biological Process GO:0050769 positive regulation of neurogenesis
Biological Process GO:0006517 protein deglycosylation
Biological Process GO:0006486 protein glycosylation
Biological Process GO:0007585 respiratory gaseous exchange by respiratory system
Biological Process GO:0060042 retina morphogenesis in camera-type eye
Biological Process GO:0007033 vacuole organization
molecular function GO:0030246 carbohydrate binding
molecular function GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
molecular function GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
molecular function GO:0046872 metal ion binding
molecular function GO:0042803 protein homodimerization activity
cellular component GO:0005801 cis-Golgi network
cellular component GO:0070062 extracellular exosome
cellular component GO:0005797 Golgi medial cisterna
cellular component GO:0000139 Golgi membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0016020 membrane
Reactome
Pathway Id Pathway Name
R-HSA-1643685 Disease
R-HSA-199991 Membrane Trafficking
R-HSA-392499 Metabolism of proteins
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5663205 Infectious disease
R-HSA-597592 Post-translational protein modification
R-HSA-6811438 Intra-Golgi traffic
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-948021 Transport to the Golgi and subsequent modification
R-HSA-9679506 SARS-CoV Infections
R-HSA-9694516 SARS-CoV-2 Infection
R-HSA-9694548 Maturation of spike protein
R-HSA-9694635 Translation of structural proteins
R-HSA-975576 N-glycan antennae elongation in the medial/trans-Golgi
R-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002876 BXGD000136 Congenital dyserythropoietic anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0008497 BXGD000549 Choriocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0596887 BXGD009648 mathematical ability
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678199 BXGD009745 Anemia of inadequate production Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306589 BXGD012369 Congenital dyserythropoietic anemia, type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2895206 BXGD017852 Autoimmune disease (systemic) NOS
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0012481 (2R,3R,4S)-2-(((R)-2-Hydroxy-1-Phenylethylamino)Methyl)Pyrrolidine-3,4-Diol 252.15
BXGC0012694 Iminoribitol 133.07
BXGC0030236 Deoxymannojirimycin 163.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein