Showing entry for Deoxymannojirimycin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0030236
Compound NameDeoxymannojirimycin
Structure
FormulaC6H13NO4
InchiKeyLXBIFEVIBLOUGU-KVTDHHQDSA-N
SMILESOC[C@H]1NC[C@H]([C@H]([C@@H]1O)O)O
InchiInChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4-,5-,6-/m1/s1
IUPAC(2R,3R,4R,5R)-2-(hydroxymethyl)piperidine-3,4,5-triol
Molecular Weight163.08
Pubchem Id72258
Chembl IdCHEMBL84844
Targets of Information Source
DrugBank DB03955
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Q16706 BXGT013660 Alpha-mannosidase 2 reviewed - MAN2A1 experimental -
PDB DMJ
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Q9UKM7 BXGT021747 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase reviewed MAN1B1 Chaperone - 20000 - -
P32906 BXGT009677 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase reviewed MNS1 - - - - -
Q24451 BXGT013891 Alpha-mannosidase 2 reviewed alpha-Man-IIa - - 400000 - -
P31723 BXGT009573 Mannosyl-oligosaccharide alpha-1,2-mannosidase reviewed MSDC - - - - -
A0A0H2URZ6 BXGT000278 Uncharacterized protein unreviewed SP_2144 - - - - -
D6D1V7 BXGT002974 Glycosyl hydrolase family 71 unreviewed BXY_34140 - - - - -
M1E1E9 BXGT003839 Ccman5 unreviewed - - - - -
Q9Z4P9 BXGT022424 Alpha-1,6-mannanase unreviewed aman6 - - - - -
B0SWV2 BXGT001857 Mannosyl-oligosaccharide 1,2-alpha-mannosidase unreviewed Caul_4035 - - - 481 -
Binding DB 50065259
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT014117 Tissue alpha-L-fucosidase reviewed FUCA1 4700 - - -
reviewed BXGT006142 Tissue alpha-L-fucosidase reviewed FUCA1 4700 - - -
reviewed BXGT006142 Tissue alpha-L-fucosidase reviewed FUCA1 - 221000 - -
reviewed BXGT022231 Epididymis-specific alpha-mannosidase reviewed MAN2B2 - 560000 - -
reviewed BXGT014117 Tissue alpha-L-fucosidase reviewed FUCA1 - 39000 - -
reviewed BXGT008901 Sucrase-isomaltase, intestinal reviewed Si - 110000 - -
reviewed BXGT006142 Tissue alpha-L-fucosidase reviewed FUCA1 30000 - - -
CHEMBL CHEMBL84844
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q8A0E8 BXGT017766 Alpha-1,2-mannosidase, putative unreviewed - BT_4073 Ki '=' 13000000 nM
Q8A193 BXGT017780 Alpha-1,2-mannosidase, putative unreviewed - BT_3773 Ki '=' 13000000 nM
Q8A325 BXGT017805 Alpha-1,2-mannosidase, putative unreviewed - BT_3130 Ki '=' 13000000 nM
Q8A1X8 BXGT017791 Putative alpha-1,2-mannosidase unreviewed - BT_3530 Ki '=' 13000000 nM
Q8A5X5 BXGT017834 Putative alpha-1,2-mannosidase unreviewed - BT_2111 Ki '=' 13000000 nM
Q8A0Q6 BXGT017771 Putative alpha-1,2-mannosidase unreviewed - BT_3965 Ki '=' 13000000 nM
Q8A5Y1 BXGT017835 Putative alpha-1,2-mannosidase unreviewed - BT_2105 Ki '=' 13000000 nM
Q8A113 BXGT017775 Alpha-1,2-mannosidase unreviewed - BT_3858 Ki '=' 13000000 nM
Q8A0C8 BXGT017764 Alpha-1,2-mannosidase family protein unreviewed - BT_4093 Ki '=' 13000000 nM
Q8A8Y5 BXGT017865 Alpha-1,2-mannosidase family protein unreviewed - BT_1032 Ki '=' 13000000 nM
Q8A6V7 BXGT017846 Putative alpha-1,2-mannosidase unreviewed - BT_1769 Ki '=' 13000000 nM
Q8A3K6 BXGT017810 Putative alpha-1,2-mannosidase unreviewed - BT_2948 Ki '=' 13000000 nM
Q8A0N0 BXGT017768 Putative alpha-1,2-mannosidase unreviewed - BT_3991 Ki '=' 13000000 nM
Q8A0Q8 BXGT017772 Glycoside hydrolase family 92 unreviewed - BT_3963 Ki '=' 13000000 nM
Q8A0M7 BXGT017767 Putative alpha-1,2-mannosidase unreviewed - BT_3994 Ki '=' 13000000 nM
Q8A6K3 BXGT017840 Putative alpha-1,2-mannosidase unreviewed - BT_1878 Ki '=' 13000000 nM
Q8A0C9 BXGT017765 Putative alpha-1,2-mannosidase unreviewed - BT_4092 Ki '=' 13000000 nM
Q8A4H0 BXGT017816 Putative alpha-1,2-mannosidase unreviewed - BT_2629 Ki '=' 13000000 nM
Q8A182 BXGT017777 Putative alpha-1,2-mannosidase unreviewed - BT_3784 Ki '=' 13000000 nM
Q8A0Q9 BXGT017773 Glycoside hydrolase family 92 unreviewed - BT_3962 Ki '=' 13000000 nM
Q8A1Y1 BXGT017792 Alpha-1,2-mannosidase unreviewed - BT_3527 Ki '=' 13000000 nM
Q8A5N9 BXGT017826 Alpha-1,2-mannosidase unreviewed - BT_2199 Ki '=' 13000000 nM
Q8A0N1 BXGT017769 Putative alpha-1,2-mannosidase unreviewed - BT_3990 Ki '=' 13000000 nM
O00462 BXGT003925 Beta-mannosidase reviewed Enzyme MANBA Activity - - -
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA Potency - 28183 nM
Q58D55 BXGT015223 Beta-galactosidase reviewed - GLB1 Inhibition '<' 50 %
O00462 BXGT003925 Beta-mannosidase reviewed Enzyme MANBA Inhibition '<' 50 %
Q2KIM0 BXGT014117 Tissue alpha-L-fucosidase reviewed - FUCA1 Ki '=' 4700 nM
Q14697 BXGT013501 Neutral alpha-glucosidase AB reviewed Enzyme GANAB Activity - - -
Q9SEH8 BXGT021581 alpha-1,2-Mannosidase unreviewed - Man1 Ki '=' 18000 nM
O43451 BXGT004594 Maltase-glucoamylase, intestinal reviewed Enzyme MGAM Inhibition '<' 50 %
P16278 BXGT008213 Beta-galactosidase reviewed Enzyme GLB1 Inhibition '<' 50 %
Q9SEH8 BXGT021581 alpha-1,2-Mannosidase unreviewed - Man1 Inhibition '<' 50 %
Q9Y2E5 BXGT022231 Epididymis-specific alpha-mannosidase reviewed - MAN2B2 IC50 '=' 560000 nM
Q2KIM0 BXGT014117 Tissue alpha-L-fucosidase reviewed - FUCA1 IC50 '=' 39000 nM
O00754 BXGT003944 Lysosomal alpha-mannosidase reviewed - MAN2B1 Inhibition '<' 50 %
P04066 BXGT006142 Tissue alpha-L-fucosidase reviewed - FUCA1 IC50 '=' 221000 nM
Q4FZV0 BXGT014807 Beta-mannosidase reviewed - Manba Inhibition '<' 50 %
P23458 BXGT008868 Tyrosine-protein kinase JAK1 reviewed Kinase JAK1 Inhibition - - -
D3ZUM4 BXGT002920 Beta-galactosidase unreviewed - Glb1 Inhibition '<' 50 %
Q9SEH8 BXGT021581 alpha-1,2-Mannosidase unreviewed - Man1 IC50 '=' 840000 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA Potency '=' 28183 nM
Q9H227 BXGT020447 Cytosolic beta-glucosidase reviewed Enzyme GBA3 Inhibition '<' 50 %
P04066 BXGT006142 Tissue alpha-L-fucosidase reviewed - FUCA1 Ki '=' 4700 nM
Q8A0E8 BXGT017766 Alpha-1,2-mannosidase, putative unreviewed - BT_4073 Ki '=' 12000000 nM
Q8A193 BXGT017780 Alpha-1,2-mannosidase, putative unreviewed - BT_3773 Ki '=' 12000000 nM
Q8A325 BXGT017805 Alpha-1,2-mannosidase, putative unreviewed - BT_3130 Ki '=' 12000000 nM
Q8A1X8 BXGT017791 Putative alpha-1,2-mannosidase unreviewed - BT_3530 Ki '=' 12000000 nM
Q8A5X5 BXGT017834 Putative alpha-1,2-mannosidase unreviewed - BT_2111 Ki '=' 12000000 nM
Q8A0Q6 BXGT017771 Putative alpha-1,2-mannosidase unreviewed - BT_3965 Ki '=' 12000000 nM
Q8A5Y1 BXGT017835 Putative alpha-1,2-mannosidase unreviewed - BT_2105 Ki '=' 12000000 nM
Q8A113 BXGT017775 Alpha-1,2-mannosidase unreviewed - BT_3858 Ki '=' 12000000 nM
Q8A0C8 BXGT017764 Alpha-1,2-mannosidase family protein unreviewed - BT_4093 Ki '=' 12000000 nM
Q8A8Y5 BXGT017865 Alpha-1,2-mannosidase family protein unreviewed - BT_1032 Ki '=' 12000000 nM
Q8A6V7 BXGT017846 Putative alpha-1,2-mannosidase unreviewed - BT_1769 Ki '=' 12000000 nM
Q8A3K6 BXGT017810 Putative alpha-1,2-mannosidase unreviewed - BT_2948 Ki '=' 12000000 nM
Q8A0N0 BXGT017768 Putative alpha-1,2-mannosidase unreviewed - BT_3991 Ki '=' 12000000 nM
Q8A0Q8 BXGT017772 Glycoside hydrolase family 92 unreviewed - BT_3963 Ki '=' 12000000 nM
Q8A0M7 BXGT017767 Putative alpha-1,2-mannosidase unreviewed - BT_3994 Ki '=' 12000000 nM
Q8A6K3 BXGT017840 Putative alpha-1,2-mannosidase unreviewed - BT_1878 Ki '=' 12000000 nM
Q8A0C9 BXGT017765 Putative alpha-1,2-mannosidase unreviewed - BT_4092 Ki '=' 12000000 nM
Q8A4H0 BXGT017816 Putative alpha-1,2-mannosidase unreviewed - BT_2629 Ki '=' 12000000 nM
Q8A182 BXGT017777 Putative alpha-1,2-mannosidase unreviewed - BT_3784 Ki '=' 12000000 nM
Q8A0Q9 BXGT017773 Glycoside hydrolase family 92 unreviewed - BT_3962 Ki '=' 12000000 nM
Q8A1Y1 BXGT017792 Alpha-1,2-mannosidase unreviewed - BT_3527 Ki '=' 12000000 nM
Q8A5N9 BXGT017826 Alpha-1,2-mannosidase unreviewed - BT_2199 Ki '=' 12000000 nM
Q8A0N1 BXGT017769 Putative alpha-1,2-mannosidase unreviewed - BT_3990 Ki '=' 12000000 nM
Q9UUZ4 BXGT021832 Alpha-galactosidase C reviewed - aglC Inhibition '<' 50 %
Q9LGC6 BXGT021076 Putative alpha-glucosidase unreviewed - P0504H10.9 Inhibition '<' 50 %
Q5DUH8 BXGT015324 Alpha-galactosidase unreviewed - gal1 Inhibition '<' 50 %
P23739 BXGT008901 Sucrase-isomaltase, intestinal reviewed - Si IC50 '=' 110000 nM
P06280 BXGT006433 Alpha-galactosidase A reviewed - GLA Inhibition '<' 50 %
P04066 BXGT006142 Tissue alpha-L-fucosidase reviewed - FUCA1 Ki '=' 30000 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency '=' 1778 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF03999 Angylocalyx pynaertii Angylocalyx pynaertii Others
BXGF04454 Scorzoneroides autumnalis Scorzoneroides autumnalis Others
BXGF05329 Lactuca floridana Lactuca floridana Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease