adisease

Showing entry for Choriocarcinoma

General Disease Information
BXGD Id	BXGD000549
Disease Name	Choriocarcinoma
Disease CUI Id	C0008497
MeSH Codes	C04 C13
Disease Class Name	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
Semantic Type	Neoplastic Process
Human Phenotype Ontology Id	HP:0001197 HP:0000119 HP:0002664
Human Phenotype Ontology Term	Abnormality of prenatal development or birth; Abnormality of the genitourinary system; Neoplasm
Disease Ontology Id	DOID:7 DOID:14566
Disease Ontology Class Name	disease of anatomical entity; disease of cellular proliferation
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00264	BXGT003904	Membrane-associated progesterone receptor component 1	10857	reviewed	Signaling
O00299	BXGT003905	Chloride intracellular channel protein 1	1192	reviewed	Ion channel
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O14638	BXGT004077	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	5169	reviewed	Enzyme
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O15151	BXGT004132	Protein Mdm4	4194	reviewed	Nucleic acid binding
O15374	BXGT004157	Monocarboxylate transporter 5	9122	reviewed	Transporter
O15379	BXGT004159	Histone deacetylase 3	8841	reviewed	Epigenetic regulator
O15427	BXGT004167	Monocarboxylate transporter 4	9123	reviewed	Transporter
O43704	BXGT004615	Sulfotransferase family cytosolic 1B member 1	27284	reviewed
O60674	BXGT004892	Tyrosine-protein kinase JAK2	3717	reviewed	Kinase
O75751	BXGT005150	Solute carrier family 22 member 3	6581	reviewed	Transporter
O76082	BXGT005175	Solute carrier family 22 member 5	6584	reviewed	Transporter
O94907	BXGT005340	Dickkopf-related protein 1	22943	reviewed
P00374	BXGT005520	Dihydrofolate reductase	1719	reviewed	Enzyme
P00451	BXGT005545	Coagulation factor VIII	2157	reviewed	Enzyme
P00492	BXGT005556	Hypoxanthine-guanine phosphoribosyltransferase	3251	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00813	BXGT005667	Adenosine deaminase	100	reviewed	Enzyme
P01019	BXGT005717	Angiotensinogen	183	reviewed	Enzyme modulator
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01130	BXGT005735	Low-density lipoprotein receptor	3949	reviewed
P01133	BXGT005736	Pro-epidermal growth factor	1950	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01215	BXGT005743	Glycoprotein hormones alpha chain	1081	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01574	BXGT005768	Interferon beta	3456	reviewed
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02766	BXGT005953	Transthyretin	7276	reviewed	Transporter
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P03950	BXGT006116	Angiogenin	283	reviewed
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04406	BXGT006207	Glyceraldehyde-3-phosphate dehydrogenase	2597	reviewed	Enzyme
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04792	BXGT006264	Heat shock protein beta-1	3315	reviewed
P05108	BXGT006317	Cholesterol side-chain cleavage enzyme, mitochondrial	1583	reviewed
P05120	BXGT006319	Plasminogen activator inhibitor 2	5055	reviewed	Enzyme modulator
P05187	BXGT006339	Alkaline phosphatase, placental type	250	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05413	BXGT006355	Fatty acid-binding protein, heart	2170	reviewed
P05556	BXGT006368	Integrin beta-1	3688	reviewed	Receptor
P05787	BXGT006385	Keratin, type II cytoskeletal 8	3856	reviewed
P05937	BXGT006396	Calbindin	793	reviewed	Calcium-binding protein
P06213	BXGT006425	Insulin receptor	3643	reviewed	Kinase
P06401	BXGT006436	Progesterone receptor	5241	reviewed	Nuclear receptor
P06850	BXGT006511	Corticoliberin	1392	reviewed	Signaling
P07333	BXGT006602	Macrophage colony-stimulating factor 1 receptor	1436	reviewed	Kinase
P07741	BXGT006666	Adenine phosphoribosyltransferase	353	reviewed
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08195	BXGT006745	4F2 cell-surface antigen heavy chain	6520	reviewed	Transporter
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08581	BXGT006794	Hepatocyte growth factor receptor	4233	reviewed	Kinase
P08620	BXGT006800	Fibroblast growth factor 4	2249	reviewed	Signaling
P08758	BXGT006821	Annexin A5	308	reviewed
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09382	BXGT006882	Galectin-1	3956	reviewed	Signaling
P09466	BXGT006892	Glycodelin	5047	reviewed	Enzyme
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P09619	BXGT006911	Platelet-derived growth factor receptor beta	5159	reviewed	Kinase
P09923	BXGT006942	Intestinal-type alkaline phosphatase	248	reviewed	Enzyme
P10109	BXGT007538	Adrenodoxin, mitochondrial	2230	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10636	BXGT007596	Microtubule-associated protein tau	4137	reviewed
P10696	BXGT007603	Alkaline phosphatase, germ cell type	251	reviewed	Enzyme
P10721	BXGT007605	Mast/stem cell growth factor receptor Kit	3815	reviewed	Kinase
P10997	BXGT007643	Islet amyloid polypeptide	3375	reviewed	Signaling
P11021	BXGT007644	Endoplasmic reticulum chaperone BiP	3309	reviewed
P11169	BXGT007664	Solute carrier family 2, facilitated glucose transporter member 3	6515	reviewed	Transporter
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P11511	BXGT007717	Aromatase	1588	reviewed	Enzyme
P12643	BXGT007830	Bone morphogenetic protein 2	650	reviewed	Signaling
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13569	BXGT007923	Cystic fibrosis transmembrane conductance regulator	1080	reviewed	Ion channel
P13688	BXGT007943	Carcinoembryonic antigen-related cell adhesion molecule 1	634	reviewed
P14060	BXGT007978	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1	3283	reviewed	Enzyme
P14061	BXGT007979	Estradiol 17-beta-dehydrogenase 1	3292	reviewed	Enzyme
P14210	BXGT007994	Hepatocyte growth factor	3082	reviewed	Enzyme
P14618	BXGT008027	Pyruvate kinase PKM	5315	reviewed	Kinase
P14635	BXGT008031	G2/mitotic-specific cyclin-B1	891	reviewed	Enzyme modulator
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15036	BXGT008073	Protein C-ets-2	2114	reviewed	Transcription factor
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P15311	BXGT008106	Ezrin	7430	reviewed	Cellular structure
P15531	BXGT008136	Nucleoside diphosphate kinase A	4830	reviewed	Kinase
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P15813	BXGT008158	Antigen-presenting glycoprotein CD1d	912	reviewed
P15941	BXGT008176	Mucin-1	4582	reviewed
P16070	BXGT008186	CD44 antigen	960	reviewed
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P16442	BXGT008227	Histo-blood group ABO system transferase	28	reviewed	Enzyme
P17948	BXGT008358	Vascular endothelial growth factor receptor 1	2321	reviewed	Kinase
P18827	BXGT008427	Syndecan-1	6382	reviewed	Extracellular structure
P19438	BXGT008480	Tumor necrosis factor receptor superfamily member 1A	7132	reviewed
P19793	BXGT008515	Retinoic acid receptor RXR-alpha	6256	reviewed	Nuclear receptor
P19883	BXGT008528	Follistatin	10468	reviewed	Enzyme modulator
P20813	BXGT008603	Cytochrome P450 2B6	1555	reviewed
P20936	BXGT008619	Ras GTPase-activating protein 1	5921	reviewed	Enzyme modulator
P21579	BXGT008665	Synaptotagmin-1	6857	reviewed	Transporter
P21802	BXGT008691	Fibroblast growth factor receptor 2	2263	reviewed	Kinase
P21860	BXGT008698	Receptor tyrosine-protein kinase erbB-3	2065	reviewed	Kinase
P22607	BXGT008784	Fibroblast growth factor receptor 3	2261	reviewed	Kinase
P22897	BXGT008816	Macrophage mannose receptor 1	4360	reviewed
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P23946	BXGT008932	Chymase	1215	reviewed	Enzyme
P24468	BXGT008969	COUP transcription factor 2	7026	reviewed	Nuclear receptor
P24530	BXGT008975	Endothelin receptor type B	1910	reviewed	G-protein coupled receptor
P24855	BXGT008998	Deoxyribonuclease-1	1773	reviewed
P25101	BXGT009018	Endothelin-1 receptor	1909	reviewed	G-protein coupled receptor
P25116	BXGT009025	Proteinase-activated receptor 1	2149	reviewed	G-protein coupled receptor
P26358	BXGT009104	DNA (cytosine-5)-methyltransferase 1	1786	reviewed	Epigenetic regulator
P27361	BXGT009176	Mitogen-activated protein kinase 3	5595	reviewed	Kinase
P27797	BXGT009206	Calreticulin	811	reviewed	Calcium-binding protein
P28223	BXGT009239	5-hydroxytryptamine receptor 2A	3356	reviewed	G-protein coupled receptor
P28347	BXGT009257	Transcriptional enhancer factor TEF-1	7003	reviewed	Transcription factor
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P29323	BXGT009334	Ephrin type-B receptor 2	2048	reviewed	Kinase
P30279	BXGT009415	G1/S-specific cyclin-D2	894	reviewed	Enzyme modulator
P30536	BXGT009435	Translocator protein	706	reviewed
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P31948	BXGT009590	Stress-induced-phosphoprotein 1	10963	reviewed
P33527	BXGT009728	Multidrug resistance-associated protein 1	4363	reviewed	Transporter
P34932	BXGT009772	Heat shock 70 kDa protein 4	3308	reviewed
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35398	BXGT009825	Nuclear receptor ROR-alpha	6095	reviewed	Nuclear receptor
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P35968	BXGT009887	Vascular endothelial growth factor receptor 2	3791	reviewed	Kinase
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P42224	BXGT010286	Signal transducer and activator of transcription 1-alpha/beta	6772	reviewed	Nucleic acid binding
P42330	BXGT010301	Aldo-keto reductase family 1 member C3	8644	reviewed	Enzyme
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P42702	BXGT010335	Leukemia inhibitory factor receptor	3977	reviewed	Signaling
P43080	BXGT010354	Guanylyl cyclase-activating protein 1	2978	reviewed
P46527	BXGT010525	Cyclin-dependent kinase inhibitor 1B	1027	reviewed
P48061	BXGT010616	Stromal cell-derived factor 1	6387	reviewed
P48730	BXGT010656	Casein kinase I isoform delta	1453	reviewed	Kinase
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49763	BXGT010737	Placenta growth factor	5228	reviewed	Signaling
P50747	BXGT010817	Biotin--protein ligase	3141	reviewed	Enzyme
P51681	BXGT010878	C-C chemokine receptor type 5	1234	reviewed	G-protein coupled receptor
P51692	BXGT010885	Signal transducer and activator of transcription 5B	6777	reviewed	Nucleic acid binding
P51812	BXGT010893	Ribosomal protein S6 kinase alpha-3	6197	reviewed	Kinase
P53985	BXGT011022	Monocarboxylate transporter 1	6566	reviewed	Transporter
P55211	BXGT011111	Caspase-9	842	reviewed	Enzyme
P56937	BXGT011205	3-keto-steroid reductase	51478	reviewed
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P61769	BXGT011383	Beta-2-microglobulin	567	reviewed	Immune response
P78380	BXGT011841	Oxidized low-density lipoprotein receptor 1	4973	reviewed
P78504	BXGT011844	Protein jagged-1	182	reviewed
P80188	BXGT011882	Neutrophil gelatinase-associated lipocalin	3934	reviewed	Enzyme
P80365	BXGT011895	Corticosteroid 11-beta-dehydrogenase isozyme 2	3291	reviewed	Enzyme
P84022	BXGT012027	Mothers against decapentaplegic homolog 3	4088	reviewed	Transcription factor
P98170	BXGT012231	E3 ubiquitin-protein ligase XIAP	331	reviewed	Enzyme modulator
P99999	BXGT012235	Cytochrome c	54205	reviewed
Q00987	BXGT012559	E3 ubiquitin-protein ligase Mdm2	4193	reviewed	Nucleic acid binding
Q01105	BXGT012569	Protein SET	6418	reviewed	Enzyme modulator
Q01650	BXGT012603	Large neutral amino acids transporter small subunit 1	8140	reviewed	Transporter
Q04206	BXGT012754	Transcription factor p65	5970	reviewed	Transcription factor
Q06710	BXGT012887	Paired box protein Pax-8	7849	reviewed
Q07075	BXGT012917	Glutamyl aminopeptidase	2028	reviewed	Enzyme
Q07820	BXGT012942	Induced myeloid leukemia cell differentiation protein Mcl-1	4170	reviewed	Signaling
Q07954	BXGT012950	Prolow-density lipoprotein receptor-related protein 1	4035	reviewed
Q07955	BXGT012951	Serine/arginine-rich splicing factor 1	6426	reviewed	Nucleic acid binding
Q08722	BXGT013002	Leukocyte surface antigen CD47	961	reviewed
Q13153	BXGT013319	Serine/threonine-protein kinase PAK 1	5058	reviewed	Kinase
Q13177	BXGT013323	Serine/threonine-protein kinase PAK 2	5062	reviewed	Kinase
Q13285	BXGT013335	Steroidogenic factor 1	2516	reviewed	Nuclear receptor
Q13489	BXGT013364	Baculoviral IAP repeat-containing protein 3	330	reviewed	Enzyme modulator
Q13501	BXGT013365	Sequestosome-1	8878	reviewed
Q13616	BXGT013381	Cullin-1	8454	reviewed	Enzyme
Q13625	BXGT013384	Apoptosis-stimulating of p53 protein 2	7159	reviewed	Enzyme modulator
Q13639	BXGT013389	5-hydroxytryptamine receptor 4	3360	reviewed	G-protein coupled receptor
Q14790	BXGT013505	Caspase-8	841	reviewed	Enzyme
Q15125	BXGT013543	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	10682	reviewed	Enzyme
Q15303	BXGT013557	Receptor tyrosine-protein kinase erbB-4	2066	reviewed	Kinase
Q15831	BXGT013604	Serine/threonine-protein kinase STK11	6794	reviewed	Kinase
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16674	BXGT013655	Melanoma-derived growth regulatory protein	8190	reviewed
Q16678	BXGT013656	Cytochrome P450 1B1	1545	reviewed	Enzyme
Q16706	BXGT013660	Alpha-mannosidase 2	4124	reviewed
Q2M1P5	BXGT014129	Kinesin-like protein KIF7	374654	reviewed
Q53EL6	BXGT015008	Programmed cell death protein 4	27250	reviewed	Nucleic acid binding
Q5JRX3	BXGT015457	Presequence protease, mitochondrial	10531	reviewed	Enzyme
Q6NYC1	BXGT016436	Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6	23210	reviewed	Receptor
Q6P179	BXGT016440	Endoplasmic reticulum aminopeptidase 2	64167	reviewed	Enzyme
Q6UWP2	BXGT016567	Dehydrogenase/reductase SDR family member 11	79154	reviewed	Enzyme
Q6ZN17	BXGT016631	Protein lin-28 homolog B	389421	reviewed
Q7L266	BXGT016993	Isoaspartyl peptidase/L-asparaginase	80150	reviewed	Enzyme
Q86V86	BXGT017617	Serine/threonine-protein kinase pim-3	415116	reviewed
Q8IVS2	BXGT018349	Malonyl-CoA-acyl carrier protein transacylase, mitochondrial	27349	reviewed
Q8TAF3	BXGT018786	WD repeat-containing protein 48	57599	reviewed
Q8TCT9	BXGT018801	Minor histocompatibility antigen H13	81502	reviewed	Enzyme
Q92743	BXGT019368	Serine protease HTRA1	5654	reviewed	Enzyme
Q93009	BXGT019455	Ubiquitin carboxyl-terminal hydrolase 7	7874	reviewed	Enzyme
Q96AC1	BXGT019617	Fermitin family homolog 2	10979	reviewed
Q99527	BXGT019930	G-protein coupled estrogen receptor 1	2852	reviewed	G-protein coupled receptor
Q99623	BXGT019941	Prohibitin-2	11331	reviewed
Q99814	BXGT019965	Endothelial PAS domain-containing protein 1	2034	reviewed	Transcription factor
Q9BXH1	BXGT020167	Bcl-2-binding component 3	27113	reviewed
Q9H015	BXGT020432	Solute carrier family 22 member 4	6583	reviewed	Transporter
Q9H0A0	BXGT020434	RNA cytidine acetyltransferase	55226	reviewed
Q9H4A3	BXGT020473	Serine/threonine-protein kinase WNK1	65125	reviewed	Kinase
Q9HCU9	BXGT020539	Breast cancer metastasis-suppressor 1	25855	reviewed
Q9NP58	BXGT021143	ATP-binding cassette sub-family B member 6, mitochondrial	10058	reviewed	Transporter
Q9NWT6	BXGT021234	Hypoxia-inducible factor 1-alpha inhibitor	55662	reviewed
Q9NZI8	BXGT021273	Insulin-like growth factor 2 mRNA-binding protein 1	10642	reviewed	Enzyme
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9P1W9	BXGT021296	Serine/threonine-protein kinase pim-2	11040	reviewed	Kinase
Q9UHV8	BXGT021706	Galactoside-binding soluble lectin 13	29124	reviewed	Signaling
Q9UIQ6	BXGT021721	Leucyl-cystinyl aminopeptidase	4012	reviewed	Enzyme
Q9UJW3	BXGT021732	DNA (cytosine-5)-methyltransferase 3-like	29947	reviewed
Q9ULC4	BXGT021757	Malignant T-cell-amplified sequence 1	28985	reviewed	Receptor
Q9UNQ0	BXGT021792	ATP-binding cassette sub-family G member 2	9429	reviewed	Transporter
Q9UQF0	BXGT021812	Syncytin-1	30816	reviewed
Q9Y251	BXGT022215	Heparanase	10855	reviewed	Enzyme
Q9Y263	BXGT022220	Phospholipase A-2-activating protein	9373	reviewed	Enzyme modulator
Q9Y289	BXGT022226	Sodium-dependent multivitamin transporter	8884	reviewed	Transporter
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
Q92911	BXGT022650	Sodium/iodide cotransporter	6528	reviewed	Transporter
P25054	BXGT022961	Adenomatous polyposis coli protein	324	reviewed
P09622	BXGT023116	Dihydrolipoyl dehydrogenase, mitochondrial	1738	reviewed	Enzyme
O14793	BXGT023280	Growth/differentiation factor 8	2660	reviewed	Signaling
Q99958	BXGT023732	Forkhead box protein C2	2303	reviewed	Transcription factor
Q9BQQ3	BXGT024065	Golgi reassembly-stacking protein 1	64689	reviewed
P21926	BXGT024578	CD9 antigen	928	reviewed
P20809	BXGT025043	Interleukin-11	3589	reviewed
P98082	BXGT025047	Disabled homolog 2	1601	reviewed	Signaling
P35250	BXGT025854	Replication factor C subunit 2	5982	reviewed	Enzyme
Q08477	BXGT026164	Docosahexaenoic acid omega-hydroxylase CYP4F3	4051	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}