Showing entry for Flap endonuclease GEN homolog 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013697
Protein NameFlap endonuclease GEN homolog 1
Uniport IdQ17RS7
GeneGEN1
Gene Id348654
DomainChromo_2; XPG_I; XPG_N
Pfam PF18704   PF00867   PF00752  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000724 double-strand break repair via homologous recombination
Biological Process GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint
Biological Process GO:0010824 regulation of centrosome duplication
Biological Process GO:0031297 replication fork processing
Biological Process GO:0071140 resolution of mitotic recombination intermediates
Biological Process GO:0071139 resolution of recombination intermediates
molecular function GO:0017108 5'-flap endonuclease activity
molecular function GO:0008821 crossover junction endodeoxyribonuclease activity
molecular function GO:0048256 flap endonuclease activity
molecular function GO:0000400 four-way junction DNA binding
molecular function GO:0000287 magnesium ion binding
molecular function GO:0042803 protein homodimerization activity
cellular component GO:0005813 centrosome
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-5693537 Resolution of D-Loop Structures
R-HSA-5693538 Homology Directed Repair
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-73894 DNA Repair
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0019342 BXGD001322 Genital Herpes Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0026654 BXGD001914 Moyamoya Disease Nervous System Diseases; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0042580 BXGD002992 Vesico-Ureteral Reflux Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0200635 BXGD004041 Lymphocyte Count measurement
C0235160 BXGD004726 Restless sleep Mental Disorders
C0281267 BXGD006770 bilateral breast cancer Neoplasms; Skin and Connective Tissue Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0343401 BXGD007623 MRSA - Methicillin resistant Staphylococcus aureus infection Infections
C0346153 BXGD007781 Breast Cancer, Familial Neoplasms; Skin and Connective Tissue Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0542519 BXGD009279 Congenital absence of kidney Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1609433 BXGD013438 Congenital absence of kidneys syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1619700 BXGD013459 RENAL ADYSPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1855304 BXGD015484 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1968949 BXGD016744 Cakut Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2931384 BXGD018014 Moyamoya disease 1 Nervous System Diseases; Cardiovascular Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein