Showing entry for Lysine-specific demethylase 4D


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT016211
Protein NameLysine-specific demethylase 4D
Uniport IdQ6B0I6
GeneKDM4D
Gene Id55693
DomainJmjC; JmjN
Pfam PF02373   PF02375  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071479 cellular response to ionizing radiation
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0000724 double-strand break repair via homologous recombination
Biological Process GO:0033169 histone H3-K9 demethylation
Biological Process GO:1900113 negative regulation of histone H3-K9 trimethylation
Biological Process GO:0035563 positive regulation of chromatin binding
Biological Process GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining
Biological Process GO:0001932 regulation of protein phosphorylation
molecular function GO:0031490 chromatin DNA binding
molecular function GO:0003684 damaged DNA binding
molecular function GO:0051213 dioxygenase activity
molecular function GO:0032452 histone demethylase activity
molecular function GO:0032454 histone demethylase activity (H3-K9 specific)
molecular function GO:0046872 metal ion binding
cellular component GO:0072562 blood microparticle
cellular component GO:0035097 histone methyltransferase complex
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005721 pericentric heterochromatin
cellular component GO:0035861 site of double-strand break
Reactome
Pathway Id Pathway Name
R-HSA-3214842 HDMs demethylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-4839726 Chromatin organization
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0281361 BXGD006774 Adenocarcinoma of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0002485 2-Oxopentanedioic acid 146.1
BXGC0002588 Magnesium 24.31
BXGC0002722 Nitrate 62
BXGC0003398 Lumazine 164.12
BXGC0003705 Chloride 35.45
BXGC0004707 4'-Hydroxyacetophenone 136.15
BXGC0004753 Phthalic acid 166.13
BXGC0005871 Dopamine 153.18
BXGC0022608 S-oxocysteine 136.01
BXGC0031449 1,3-propanediol 76.05
BXGC0033921 Isatin 147.03
BXGC0040248 Dimedazol 146.08
BXGC0040525 2-Methylbenzenesulfonimidic Acid 171.04
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein