Showing entry for E3 ubiquitin-protein ligase SIAH1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT018336
Protein NameE3 ubiquitin-protein ligase SIAH1
Uniport IdQ8IUQ4
GeneSIAH1
Gene Id6477
DomainSina
Pfam PF03145  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.2 Cell growth and death hsa04115 p53 signaling pathway
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04120 Ubiquitin mediated proteolysis
3. Environmental Information Processing 3.2 Signal transduction hsa04310 Wnt signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0009653 anatomical structure morphogenesis
Biological Process GO:0006915 apoptotic process
Biological Process GO:0007411 axon guidance
Biological Process GO:0007049 cell cycle
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:1902842 negative regulation of netrin-activated signaling pathway
Biological Process GO:0007399 nervous system development
Biological Process GO:0051402 neuron apoptotic process
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0030163 protein catabolic process
Biological Process GO:0031648 protein destabilization
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0007283 spermatogenesis
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
molecular function GO:0042802 identical protein binding
molecular function GO:0008022 protein C-terminus binding
molecular function GO:0031624 ubiquitin conjugating enzyme binding
molecular function GO:0061630 ubiquitin protein ligase activity
molecular function GO:0004842 ubiquitin-protein transferase activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0030877 beta-catenin destruction complex
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005769 early endosome
cellular component GO:0042025 host cell nucleus
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System
R-HSA-373752 Netrin-1 signaling
R-HSA-392499 Metabolism of proteins
R-HSA-422475 Axon guidance
R-HSA-9675108 Nervous system development
R-HSA-977225 Amyloid fiber formation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0004114 BXGD000255 Astrocytoma Neoplasms
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0020428 BXGD001377 Hyperaldosteronism Endocrine System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0035112 BXGD002508 Reoviridae Infections Infections
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0153382 BXGD003627 Malignant neoplasm of oropharynx Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0302142 BXGD006831 Deformity Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0339115 BXGD007225 Sebaceous adenocarcinoma of eyelid Neoplasms; Skin and Connective Tissue Diseases
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1384514 BXGD012940 Conn Syndrome Endocrine System Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2349952 BXGD017065 Oropharyngeal Carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3811653 BXGD019662 Experimental Organism Basal Cell Carcinoma Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4721806 BXGD023772 Carcinoma, Basal Cell Neoplasms
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein