Showing entry for Negative elongation factor C/D


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT018359
Protein NameNegative elongation factor C/D
Uniport IdQ8IXH7
GeneNELFCD
Gene Id51497
DomainTH1
Pfam PF04858  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter
Biological Process GO:0050434 positive regulation of viral transcription
Biological Process GO:0006366 transcription by RNA polymerase II
Biological Process GO:0006368 transcription elongation from RNA polymerase II promoter
molecular function GO:0003723 RNA binding
cellular component GO:0016020 membrane
cellular component GO:0032021 NELF complex
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-112382 Formation of RNA Pol II elongation complex
R-HSA-113418 Formation of the Early Elongation Complex
R-HSA-162587 HIV Life Cycle
R-HSA-162587 HIV Life Cycle
R-HSA-162599 Late Phase of HIV Life Cycle
R-HSA-162599 Late Phase of HIV Life Cycle
R-HSA-162906 HIV Infection
R-HSA-162906 HIV Infection
R-HSA-1643685 Disease
R-HSA-1643685 Disease
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex
R-HSA-167169 HIV Transcription Elongation
R-HSA-167169 HIV Transcription Elongation
R-HSA-167172 Transcription of the HIV genome
R-HSA-167172 Transcription of the HIV genome
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287 HIV elongation arrest and recovery
R-HSA-167290 Pausing and recovery of HIV elongation
R-HSA-212436 Generic Transcription Pathway
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-5663205 Infectious disease
R-HSA-5663205 Infectious disease
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-75955 RNA Polymerase II Transcription Elongation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002390 BXGD000110 Extrinsic allergic alveolitis Respiratory Tract Diseases; Immune System Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0008312 BXGD000527 Primary biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0018889 BXGD001243 Helminthiasis Infections
C0022346 BXGD001537 Icterus Pathological Conditions, Signs and Symptoms
C0023290 BXGD001631 Leishmaniasis, Visceral Infections
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024198 BXGD001743 Lyme Disease Infections
C0024266 BXGD001754 Lymphocytic Choriomeningitis Infections; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0043194 BXGD003036 Wiskott-Aldrich Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0085077 BXGD003117 Sweet Syndrome Skin and Connective Tissue Diseases
C0085652 BXGD003224 Pyoderma Gangrenosum Skin and Connective Tissue Diseases
C0153014 BXGD003612 Non-arthropod borne lymphocytic choriomeningitis Infections; Nervous System Diseases
C0748720 BXGD010203 Chronic sinus disease
C1269955 BXGD012005 Tumor Cell Invasion
C1839163 BXGD014360 THROMBOCYTOPENIA 1 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C2937365 BXGD018161 Recurrent aphthous ulcer Stomatognathic Diseases
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein