Showing entry for Endonuclease 8-like 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019612
Protein NameEndonuclease 8-like 2
Uniport IdQ969S2
GeneNEIL2
Gene Id252969
DomainH2TH
Pfam PF06831  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.4 Replication and repair hsa03410 Base excision repair
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006284 base-excision repair
Biological Process GO:0045008 depyrimidination
Biological Process GO:0006289 nucleotide-excision repair
molecular function GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity
molecular function GO:0003684 damaged DNA binding
molecular function GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
molecular function GO:0019104 DNA N-glycosylase activity
molecular function GO:0008017 microtubule binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005654 nucleoplasm
cellular component GO:0005876 spindle microtubule
Reactome
Pathway Id Pathway Name
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine
R-HSA-110329 Cleavage of the damaged pyrimidine
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
R-HSA-73884 Base Excision Repair
R-HSA-73894 DNA Repair
R-HSA-73928 Depyrimidination
R-HSA-73929 Base-Excision Repair, AP Site Formation
R-HSA-73933 Resolution of Abasic Sites (AP sites)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001857 BXGD000085 AIDS related complex Infections; Immune System Diseases
C0001948 BXGD000091 Alcohol consumption Behavior and Behavior Mechanisms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0036646 BXGD002627 Age-related cataract Eye Diseases
C0153382 BXGD003627 Malignant neoplasm of oropharynx Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0200633 BXGD004040 Neutrophil count (procedure)
C0202236 BXGD004086 Triglycerides measurement
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0235833 BXGD004775 Congenital diaphragmatic hernia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0549523 BXGD009386 Oropharynx (excludes nasopharynx)
C0585362 BXGD009592 Squamous cell carcinoma of mouth Digestive System Diseases; Neoplasms; Stomatognathic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0741916 BXGD010044 Cardiac defects
C1302652 BXGD012307 Adenoma of rectum Digestive System Diseases; Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2349952 BXGD017065 Oropharyngeal Carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002616 Copper 63.55
BXGC0008661 Iron 55.85
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein