Showing entry for Ubiquitin thioesterase otulin


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019625
Protein NameUbiquitin thioesterase otulin
Uniport IdQ96BN8
GeneOTULIN
Gene Id90268
DomainPeptidase_C101
Pfam PF16218  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0045087 innate immune response
Biological Process GO:0050728 negative regulation of inflammatory response
Biological Process GO:0032088 negative regulation of NF-kappaB transcription factor activity
Biological Process GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
Biological Process GO:1990108 protein linear deubiquitination
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0060828 regulation of canonical Wnt signaling pathway
Biological Process GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
Biological Process GO:0002040 sprouting angiogenesis
Biological Process GO:0016055 Wnt signaling pathway
molecular function GO:0008234 cysteine-type peptidase activity
molecular function GO:0004843 thiol-dependent ubiquitin-specific protease activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0071797 LUBAC complex
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-392499 Metabolism of proteins
R-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-597592 Post-translational protein modification
R-HSA-73887 Death Receptor Signalling
R-HSA-75893 TNF signaling
R-HSA-8852135 Protein ubiquitination
R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003862 BXGD000230 Arthralgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0008149 BXGD000520 Chlamydia Infections Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0023518 BXGD001677 Leukocytosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0023787 BXGD001698 Lipodystrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0030326 BXGD002209 Panniculitis Skin and Connective Tissue Diseases
C0037284 BXGD002679 Skin lesion Skin and Connective Tissue Diseases
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0151683 BXGD003458 Neutrophilia (finding)
C0152031 BXGD003524 Joint swelling Pathological Conditions, Signs and Symptoms
C0221776 BXGD004481 Oral pain Pathological Conditions, Signs and Symptoms
C0231528 BXGD004496 Myalgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0497156 BXGD009053 Lymphadenopathy Hemic and Lymphatic Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C2937365 BXGD018161 Recurrent aphthous ulcer Stomatognathic Diseases
C3267073 BXGD018613 Autoinflammatory disease
C3665444 BXGD019288 Neutrophilia (disorder) Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C3860213 BXGD019844 Autoinflammatory disorder
C3890737 BXGD020025 Autoinflammatory Syndrome Pathological Conditions, Signs and Symptoms
C4310614 BXGD022598 OTULIN-related autoinflammatory syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein