Showing entry for Sphingomyelin phosphodiesterase 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021251
Protein NameSphingomyelin phosphodiesterase 3
Uniport IdQ9NY59
GeneSMPD3
Gene Id55512
Domain-
Pfam -  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00600 Sphingolipid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030509 BMP signaling pathway
Biological Process GO:0098868 bone growth
Biological Process GO:0030282 bone mineralization
Biological Process GO:0070301 cellular response to hydrogen peroxide
Biological Process GO:0071286 cellular response to magnesium ion
Biological Process GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus
Biological Process GO:1901653 cellular response to peptide
Biological Process GO:0071461 cellular response to redox state
Biological Process GO:0071356 cellular response to tumor necrosis factor
Biological Process GO:0006672 ceramide metabolic process
Biological Process GO:0003433 chondrocyte development involved in endochondral bone morphogenesis
Biological Process GO:0032963 collagen metabolic process
Biological Process GO:0097187 dentinogenesis
Biological Process GO:0071897 DNA biosynthetic process
Biological Process GO:0001958 endochondral ossification
Biological Process GO:0085029 extracellular matrix assembly
Biological Process GO:0070314 G1 to G0 transition
Biological Process GO:0006687 glycosphingolipid metabolic process
Biological Process GO:0002244 hematopoietic progenitor cell differentiation
Biological Process GO:0048286 lung alveolus development
Biological Process GO:0140014 mitotic nuclear division
Biological Process GO:0035264 multicellular organism growth
Biological Process GO:1900126 negative regulation of hyaluronan biosynthetic process
Biological Process GO:0030072 peptide hormone secretion
Biological Process GO:0048008 platelet-derived growth factor receptor signaling pathway
Biological Process GO:0015774 polysaccharide transport
Biological Process GO:2000304 positive regulation of ceramide biosynthetic process
Biological Process GO:1903543 positive regulation of exosomal secretion
Biological Process GO:0045840 positive regulation of mitotic nuclear division
Biological Process GO:0048661 positive regulation of smooth muscle cell proliferation
Biological Process GO:0043491 protein kinase B signaling
Biological Process GO:0061035 regulation of cartilage development
Biological Process GO:0002685 regulation of leukocyte migration
Biological Process GO:0001932 regulation of protein phosphorylation
Biological Process GO:0090520 sphingolipid mediated signaling pathway
Biological Process GO:0006685 sphingomyelin catabolic process
Biological Process GO:0006684 sphingomyelin metabolic process
molecular function GO:0042802 identical protein binding
molecular function GO:0046872 metal ion binding
molecular function GO:0061751 neutral sphingomyelin phosphodiesterase activity
molecular function GO:0004620 phospholipase activity
molecular function GO:0004767 sphingomyelin phosphodiesterase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005576 extracellular region
cellular component GO:0000137 Golgi cis cisterna
cellular component GO:0000139 Golgi membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction
R-HSA-1660662 Glycosphingolipid metabolism
R-HSA-428157 Sphingolipid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-5626978 TNFR1-mediated ceramide production
R-HSA-73887 Death Receptor Signalling
R-HSA-75893 TNF signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001342 BXGD000042 Acute periodontitis Stomatognathic Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005612 BXGD000317 Birth Weight Pathological Conditions, Signs and Symptoms
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0018378 BXGD001190 Guillain-Barre Syndrome Immune System Diseases; Nervous System Diseases
C0020542 BXGD001425 Pulmonary Hypertension Respiratory Tract Diseases
C0020635 BXGD001455 Hypopituitarism Nervous System Diseases; Endocrine System Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0023418 BXGD001642 leukemia Neoplasms
C0023448 BXGD001649 Lymphoid leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0023931 BXGD001722 Lobstein Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026918 BXGD001948 Mycobacterium Infections Infections
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0029434 BXGD002146 Osteogenesis Imperfecta Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031106 BXGD002283 Aggressive Periodontitis Stomatognathic Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0085681 BXGD003237 Hyperphosphatemia (disorder) Nutritional and Metabolic Diseases
C0242343 BXGD005153 Panhypopituitarism Nervous System Diseases; Endocrine System Diseases
C0268358 BXGD005913 Osteogenesis imperfecta, dominant perinatal lethal Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0268362 BXGD005915 Osteogenesis imperfecta type III (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0276289 BXGD006418 Zika Virus Infection Infections
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0343284 BXGD007613 Chondrodysplasia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0860040 BXGD011213 BCG infection
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2713368 BXGD017496 Hematopoetic Myelodysplasia Hemic and Lymphatic Diseases
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3714948 BXGD019440 PACHYONYCHIA CONGENITA 3
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein