Showing entry for PACHYONYCHIA CONGENITA 3


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD019440
Disease NamePACHYONYCHIA CONGENITA 3
Disease CUI IdC3714948
MeSH Codes   
Disease Class Name
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O14733 BXGT004087 Dual specificity mitogen-activated protein kinase kinase 7 5609 reviewed Kinase
O14788 BXGT004100 Tumor necrosis factor ligand superfamily member 11 8600 reviewed Signaling
O15296 BXGT004148 Arachidonate 15-lipoxygenase B 247 reviewed Enzyme
O15374 BXGT004157 Monocarboxylate transporter 5 9122 reviewed Transporter
O15427 BXGT004167 Monocarboxylate transporter 4 9123 reviewed Transporter
O75116 BXGT005100 Rho-associated protein kinase 2 9475 reviewed Kinase
O75164 BXGT005104 Lysine-specific demethylase 4A 9682 reviewed
O96028 BXGT005417 Histone-lysine N-methyltransferase NSD2 7468 reviewed Epigenetic regulator
P00491 BXGT005555 Purine nucleoside phosphorylase 4860 reviewed Enzyme
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P00749 BXGT005641 Urokinase-type plasminogen activator 5328 reviewed Enzyme
P00915 BXGT005689 Carbonic anhydrase 1 759 reviewed
P01009 BXGT005714 Alpha-1-antitrypsin 5265 reviewed Enzyme modulator
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01236 BXGT005744 Prolactin 5617 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P02538 BXGT005888 Keratin, type II cytoskeletal 6A 3853 reviewed
P02786 BXGT005961 Transferrin receptor protein 1 7037 reviewed Enzyme
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P03950 BXGT006116 Angiogenin 283 reviewed
P04040 BXGT006132 Catalase 847 reviewed Enzyme
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04792 BXGT006264 Heat shock protein beta-1 3315 reviewed
P05106 BXGT006315 Integrin beta-3 3690 reviewed Receptor
P05187 BXGT006339 Alkaline phosphatase, placental type 250 reviewed Enzyme
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06733 BXGT006490 Alpha-enolase 2023 reviewed Enzyme
P07225 BXGT006572 Vitamin K-dependent protein S 5627 reviewed
P07288 BXGT006591 Prostate-specific antigen 354 reviewed Enzyme
P07741 BXGT006666 Adenine phosphoribosyltransferase 353 reviewed
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08473 BXGT006773 Neprilysin 4311 reviewed Enzyme
P08581 BXGT006794 Hepatocyte growth factor receptor 4233 reviewed Kinase
P08670 BXGT006810 Vimentin 7431 reviewed
P09466 BXGT006892 Glycodelin 5047 reviewed Enzyme
P09601 BXGT006909 Heme oxygenase 1 3162 reviewed
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P09923 BXGT006942 Intestinal-type alkaline phosphatase 248 reviewed Enzyme
P0DP23 BXGT007520 Calmodulin-1 808 reviewed
P0DP24 BXGT007521 Calmodulin-2 808 reviewed
P10070 BXGT007534 Zinc finger protein GLI2 2736 reviewed
P10144 BXGT007541 Granzyme B 3002 reviewed Enzyme
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10909 BXGT007630 Clusterin 1191 reviewed
P10997 BXGT007643 Islet amyloid polypeptide 3375 reviewed Signaling
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP 3309 reviewed
P11226 BXGT007675 Mannose-binding protein C 4153 reviewed Receptor
P11309 BXGT007685 Serine/threonine-protein kinase pim-1 5292 reviewed Kinase
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P13727 BXGT007951 Bone marrow proteoglycan 5553 reviewed Enzyme modulator
P14210 BXGT007994 Hepatocyte growth factor 3082 reviewed Enzyme
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P16070 BXGT008186 CD44 antigen 960 reviewed
P18847 BXGT008431 Cyclic AMP-dependent transcription factor ATF-3 467 reviewed Transcription factor
P20248 BXGT008554 Cyclin-A2 890 reviewed Enzyme modulator
P21554 BXGT008662 Cannabinoid receptor 1 1268 reviewed G-protein coupled receptor
P21579 BXGT008665 Synaptotagmin-1 6857 reviewed Transporter
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P24941 BXGT009002 Cyclin-dependent kinase 2 1017 reviewed Kinase
P26358 BXGT009104 DNA (cytosine-5)-methyltransferase 1 1786 reviewed Epigenetic regulator
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P30989 BXGT009492 Neurotensin receptor type 1 4923 reviewed G-protein coupled receptor
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P35052 BXGT009788 Glypican-1 2817 reviewed
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35555 BXGT009845 Fibrillin-1 2200 reviewed Calcium-binding protein
P35968 BXGT009887 Vascular endothelial growth factor receptor 2 3791 reviewed Kinase
P36955 BXGT009946 Pigment epithelium-derived factor 5176 reviewed Enzyme modulator
P36969 BXGT009949 Phospholipid hydroperoxide glutathione peroxidase 2879 reviewed Enzyme
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P38936 BXGT010074 Cyclin-dependent kinase inhibitor 1 1026 reviewed
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P45983 BXGT010494 Mitogen-activated protein kinase 8 5599 reviewed Kinase
P46108 BXGT010509 Adapter molecule crk 1398 reviewed
P46937 BXGT010554 Transcriptional coactivator YAP1 10413 reviewed Enzyme modulator
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P50591 BXGT010814 Tumor necrosis factor ligand superfamily member 10 8743 reviewed Signaling
P50897 BXGT010823 Palmitoyl-protein thioesterase 1 5538 reviewed Enzyme
P51449 BXGT010846 Nuclear receptor ROR-gamma 6097 reviewed Nuclear receptor
P53041 BXGT010968 Serine/threonine-protein phosphatase 5 5536 reviewed
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 5347 reviewed Kinase
P54646 BXGT011062 5'-AMP-activated protein kinase catalytic subunit alpha-2 5563 reviewed Kinase
P54760 BXGT011075 Ephrin type-B receptor 4 2050 reviewed Kinase
P55786 BXGT011125 Puromycin-sensitive aminopeptidase 9520 reviewed Enzyme
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60568 BXGT011315 Interleukin-2 3558 reviewed
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
Q00987 BXGT012559 E3 ubiquitin-protein ligase Mdm2 4193 reviewed Nucleic acid binding
Q04206 BXGT012754 Transcription factor p65 5970 reviewed Transcription factor
Q04609 BXGT012768 Glutamate carboxypeptidase 2 2346 reviewed Enzyme
Q07108 BXGT012919 Early activation antigen CD69 969 reviewed
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 4170 reviewed Signaling
Q08722 BXGT013002 Leukocyte surface antigen CD47 961 reviewed
Q12778 BXGT013263 Forkhead box protein O1 2308 reviewed
Q13131 BXGT013314 5'-AMP-activated protein kinase catalytic subunit alpha-1 5562 reviewed Kinase
Q13155 BXGT013320 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 7965 reviewed
Q14118 BXGT013444 Dystroglycan 1605 reviewed Receptor
Q15389 BXGT013564 Angiopoietin-1 284 reviewed Signaling
Q15848 BXGT013609 Adiponectin 9370 reviewed
Q16539 BXGT013634 Mitogen-activated protein kinase 14 1432 reviewed Kinase
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q16674 BXGT013655 Melanoma-derived growth regulatory protein 8190 reviewed
Q7LG56 BXGT016999 Ribonucleoside-diphosphate reductase subunit M2 B 50484 reviewed Enzyme
Q92731 BXGT019366 Estrogen receptor beta 2100 reviewed Nuclear receptor
Q99798 BXGT019962 Aconitate hydratase, mitochondrial 50 reviewed Enzyme
Q9BZR6 BXGT020202 Reticulon-4 receptor 65078 reviewed
Q9H4A3 BXGT020473 Serine/threonine-protein kinase WNK1 65125 reviewed Kinase
Q9NY59 BXGT021251 Sphingomyelin phosphodiesterase 3 55512 reviewed
Q9Y251 BXGT022215 Heparanase 10855 reviewed Enzyme
Q9Y478 BXGT022271 5'-AMP-activated protein kinase subunit beta-1 5564 reviewed Kinase
Q9Y617 BXGT022314 Phosphoserine aminotransferase 29968 reviewed
Q9BQQ3 BXGT024065 Golgi reassembly-stacking protein 1 64689 reviewed
P0DP25 BXGT024595 Calmodulin-3 808 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease