Showing entry for Leucine--tRNA ligase, cytoplasmic


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021301
Protein NameLeucine--tRNA ligase, cytoplasmic
Uniport IdQ9P2J5
GeneLARS1
Gene Id51520
DomainAnticodon_1; tRNA-synt_1
Pfam PF08264   PF00133  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.2 Translation hsa00970 Aminoacyl-tRNA biosynthesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0034198 cellular response to amino acid starvation
Biological Process GO:0071230 cellular response to amino acid stimulus
Biological Process GO:0071233 cellular response to leucine
Biological Process GO:1990253 cellular response to leucine starvation
Biological Process GO:0006425 glutaminyl-tRNA aminoacylation
Biological Process GO:0006429 leucyl-tRNA aminoacylation
Biological Process GO:0043547 positive regulation of GTPase activity
Biological Process GO:1904263 positive regulation of TORC1 signaling
Biological Process GO:0032008 positive regulation of TOR signaling
Biological Process GO:0008361 regulation of cell size
Biological Process GO:0006418 tRNA aminoacylation for protein translation
molecular function GO:0002161 aminoacyl-tRNA editing activity
molecular function GO:0005524 ATP binding
molecular function GO:0004819 glutamine-tRNA ligase activity
molecular function GO:0005096 GTPase activator activity
molecular function GO:0004823 leucine-tRNA ligase activity
cellular component GO:0017101 aminoacyl-tRNA synthetase multienzyme complex
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0012505 endomembrane system
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005764 lysosome
cellular component GO:0016604 nuclear body
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-2408522 Selenoamino acid metabolism
R-HSA-379716 Cytosolic tRNA aminoacylation
R-HSA-379724 tRNA Aminoacylation
R-HSA-392499 Metabolism of proteins
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-72766 Translation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001125 BXGD000024 Acidosis, Lactic Nutritional and Metabolic Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0002886 BXGD000144 Anemia, Macrocytic Hemic and Lymphatic Diseases
C0005779 BXGD000336 Blood Coagulation Disorders Hemic and Lymphatic Diseases
C0007113 BXGD000430 Rectal Carcinoma Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039103 BXGD002791 Synovitis Musculoskeletal Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0042029 BXGD002951 Urinary tract infection Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0162557 BXGD003956 Liver Failure, Acute Digestive System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0262655 BXGD005264 Recurrent urinary tract infection Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0393591 BXGD008102 AICARDI-GOUTIERES SYNDROME Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0877008 BXGD011325 Enzyme inhibition disorder
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1848701 BXGD014967 Elevated hepatic transaminase
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C3809522 BXGD019595 INFANTILE LIVER FAILURE SYNDROME 1
C4524073 BXGD023087 Low anterior resection syndrome
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0032575 Leucine 131.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein