Showing entry for NPC1-like intracellular cholesterol transporter 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021696
Protein NameNPC1-like intracellular cholesterol transporter 1
Uniport IdQ9UHC9
GeneNPC1L1
Gene Id29881
DomainNPC1_N; Patched; Sterol-sensing
Pfam PF16414   PF02460   PF12349  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.4 Digestive system hsa04975 Fat digestion and absorption
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071501 cellular response to sterol depletion
Biological Process GO:0006695 cholesterol biosynthetic process
Biological Process GO:0030301 cholesterol transport
Biological Process GO:0030299 intestinal cholesterol absorption
Biological Process GO:0098856 intestinal lipid absorption
Biological Process GO:0042157 lipoprotein metabolic process
Biological Process GO:0042493 response to drug
Biological Process GO:0014850 response to muscle activity
molecular function GO:0008144 drug binding
molecular function GO:0031489 myosin V binding
molecular function GO:0017137 Rab GTPase binding
cellular component GO:0016324 apical plasma membrane
cellular component GO:0031526 brush border membrane
cellular component GO:0030659 cytoplasmic vesicle membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0044214 spanning component of plasma membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0008350 BXGD000531 Cholelithiasis Digestive System Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011311 BXGD000714 Dengue Fever Infections
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0015696 BXGD001014 Fatty Liver, Alcoholic Digestive System Diseases; Chemically-Induced Disorders
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0085762 BXGD003251 Alcohol abuse Chemically-Induced Disorders; Mental Disorders
C0151718 BXGD003464 Hypocholesterolemia Nutritional and Metabolic Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0342907 BXGD007581 Sitosterolemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0856727 BXGD011108 Cholesterol gallstones Digestive System Diseases
C0947622 BXGD011493 Cholecystolithiasis Digestive System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332347 BXGD012527 Atypical Ductal Breast Hyperplasia Neoplasms
C1445957 BXGD013081 Serum total cholesterol measurement
C1862596 BXGD016135 Familial hypobetalipoproteinemia Nutritional and Metabolic Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C3241937 BXGD018578 Nonalcoholic Steatohepatitis Digestive System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0030388 Cholestan-3Beta,5Alpha,6Beta-Triol 420.36
BXGC0038316 Cholesterol 386.35
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein