adisease

Showing entry for Cholelithiasis

General Disease Information
BXGD Id	BXGD000531
Disease Name	Cholelithiasis
Disease CUI Id	C0008350
MeSH Codes	C06
Disease Class Name	Digestive System Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0025031
Human Phenotype Ontology Term	Abnormality of the digestive system
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00299	BXGT003905	Chloride intracellular channel protein 1	1192	reviewed	Ion channel
O15438	BXGT004168	Canalicular multispecific organic anion transporter 2	8714	reviewed	Transporter
O15496	BXGT004175	Group 10 secretory phospholipase A2	8399	reviewed	Enzyme
O15527	BXGT004176	N-glycosylase/DNA lyase	4968	reviewed
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O60656	BXGT004889	UDP-glucuronosyltransferase 1-9	54600	reviewed
O95342	BXGT005373	Bile salt export pump	8647	reviewed	Transporter
O95750	BXGT005395	Fibroblast growth factor 19	9965	reviewed	Signaling
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P01009	BXGT005714	Alpha-1-antitrypsin	5265	reviewed	Enzyme modulator
P01130	BXGT005735	Low-density lipoprotein receptor	3949	reviewed
P01133	BXGT005736	Pro-epidermal growth factor	1950	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01275	BXGT005747	Glucagon	2641	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02549	BXGT005890	Spectrin alpha chain, erythrocytic 1	6708	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02654	BXGT005911	Apolipoprotein C-I	341	reviewed
P02730	BXGT005935	Band 3 anion transport protein	6521	reviewed	Transporter
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02753	BXGT005945	Retinol-binding protein 4	5950	reviewed	Transporter
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04035	BXGT006129	3-hydroxy-3-methylglutaryl-coenzyme A reductase	3156	reviewed
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04075	BXGT006145	Fructose-bisphosphate aldolase A	226	reviewed
P04278	BXGT006182	Sex hormone-binding globulin	6462	reviewed
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P05093	BXGT006313	Steroid 17-alpha-hydroxylase/17,20 lyase	1586	reviewed
P05109	BXGT006318	Protein S100-A8	6279	reviewed	Calcium-binding protein
P05231	BXGT006345	Interleukin-6	3569	reviewed
P07203	BXGT006566	Glutathione peroxidase 1	2876	reviewed	Enzyme
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08236	BXGT006752	Beta-glucuronidase	2990	reviewed
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09488	BXGT006899	Glutathione S-transferase Mu 1	2944	reviewed
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P11413	BXGT007701	Glucose-6-phosphate 1-dehydrogenase	2539	reviewed	Enzyme
P11597	BXGT007727	Cholesteryl ester transfer protein	1071	reviewed
P11802	BXGT007750	Cyclin-dependent kinase 4	1019	reviewed	Kinase
P12104	BXGT007773	Fatty acid-binding protein, intestinal	2169	reviewed
P13224	BXGT007890	Platelet glycoprotein Ib beta chain	2812	reviewed
P13945	BXGT007972	Beta-3 adrenergic receptor	155	reviewed	G-protein coupled receptor
P14555	BXGT008020	Phospholipase A2, membrane associated	5320	reviewed	Enzyme
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15289	BXGT008102	Arylsulfatase A	410	reviewed	Enzyme
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P15884	BXGT008166	Transcription factor 4	6925	reviewed	Transcription factor
P15941	BXGT008176	Mucin-1	4582	reviewed
P16157	BXGT008203	Ankyrin-1	286	reviewed
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P16671	BXGT008255	Platelet glycoprotein 4	948	reviewed	Receptor
P17405	BXGT008304	Sphingomyelin phosphodiesterase	6609	reviewed	Enzyme
P18887	BXGT008437	DNA repair protein XRCC1	7515	reviewed
P19224	BXGT008468	UDP-glucuronosyltransferase 1-6	54578	reviewed
P19367	BXGT008476	Hexokinase-1	3098	reviewed	Kinase
P21439	BXGT008649	Phosphatidylcholine translocator ABCB4	5244	reviewed	Transporter
P21964	BXGT008714	Catechol O-methyltransferase	1312	reviewed	Enzyme
P22309	BXGT008753	UDP-glucuronosyltransferase 1-1	54658	reviewed
P22310	BXGT008754	UDP-glucuronosyltransferase 1-4	54657	reviewed
P22352	BXGT008758	Glutathione peroxidase 3	2878	reviewed	Enzyme
P22455	BXGT008772	Fibroblast growth factor receptor 4	2264	reviewed	Kinase
P22680	BXGT008794	Cholesterol 7-alpha-monooxygenase	1581	reviewed	Enzyme
P22830	BXGT008809	Ferrochelatase, mitochondrial	2235	reviewed	Enzyme
P24298	BXGT008960	Alanine aminotransferase 1	2875	reviewed	Enzyme
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	328	reviewed
P30533	BXGT009434	Alpha-2-macroglobulin receptor-associated protein	4043	reviewed
P30613	BXGT009447	Pyruvate kinase PKLR	5313	reviewed	Kinase
P30711	BXGT009460	Glutathione S-transferase theta-1	2952	reviewed
P31513	BXGT009546	Dimethylaniline monooxygenase [N-oxide-forming] 3	2328	reviewed	Enzyme
P32238	BXGT009611	Cholecystokinin receptor type A	886	reviewed	G-protein coupled receptor
P32241	BXGT009613	Vasoactive intestinal polypeptide receptor 1	7433	reviewed	G-protein coupled receptor
P32245	BXGT009614	Melanocortin receptor 4	4160	reviewed	G-protein coupled receptor
P35228	BXGT009800	Nitric oxide synthase, inducible	4843	reviewed
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35503	BXGT009840	UDP-glucuronosyltransferase 1-3	54659	reviewed
P36578	BXGT009928	60S ribosomal protein L4	6124	reviewed
P37023	BXGT009953	Serine/threonine-protein kinase receptor R3	94	reviewed	Kinase
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P39748	BXGT010134	Flap endonuclease 1	2237	reviewed	Enzyme
P41235	BXGT010241	Hepatocyte nuclear factor 4-alpha	3172	reviewed	Nuclear receptor
P41279	BXGT010254	Mitogen-activated protein kinase kinase kinase 8	1326	reviewed	Kinase
P43220	BXGT010367	Glucagon-like peptide 1 receptor	2740	reviewed	G-protein coupled receptor
P46721	BXGT010536	Solute carrier organic anion transporter family member 1A2	6579	reviewed	Transporter
P47871	BXGT010592	Glucagon receptor	2642	reviewed	G-protein coupled receptor
P48357	BXGT010627	Leptin receptor	3953	reviewed	Signaling
P49888	BXGT010756	Estrogen sulfotransferase	6783	reviewed
P51161	BXGT010841	Gastrotropin	2172	reviewed
P51681	BXGT010878	C-C chemokine receptor type 5	1234	reviewed	G-protein coupled receptor
P53667	BXGT011008	LIM domain kinase 1	3984	reviewed	Kinase
P60174	BXGT011294	Triosephosphate isomerase	7167	reviewed	Enzyme
P68871	BXGT011615	Hemoglobin subunit beta	3043	reviewed
P69905	BXGT011649	Hemoglobin subunit alpha	3040	reviewed
P80188	BXGT011882	Neutrophil gelatinase-associated lipocalin	3934	reviewed	Enzyme
P98164	BXGT012230	Low-density lipoprotein receptor-related protein 2	4036	reviewed
Q01831	BXGT012621	DNA repair protein complementing XP-C cells	7508	reviewed	Nucleic acid binding
Q05823	BXGT012840	2-5A-dependent ribonuclease	6041	reviewed	Kinase
Q09013	BXGT013023	Myotonin-protein kinase	1760	reviewed	Kinase
Q12908	BXGT013278	Ileal sodium/bile acid cotransporter	6555	reviewed	Transporter
Q13133	BXGT013315	Oxysterols receptor LXR-alpha	10062	reviewed	Nuclear receptor
Q13163	BXGT013321	Dual specificity mitogen-activated protein kinase kinase 5	5607	reviewed	Kinase
Q13485	BXGT013363	Mothers against decapentaplegic homolog 4	4089	reviewed	Transcription factor
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14973	BXGT013515	Sodium/bile acid cotransporter	6554	reviewed	Transporter
Q15465	BXGT013573	Sonic hedgehog protein	6469	reviewed
Q15652	BXGT013587	Probable JmjC domain-containing histone demethylation protein 2C	221037	reviewed
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q86TM3	BXGT017607	Probable ATP-dependent RNA helicase DDX53	168400	reviewed
Q8NBP7	BXGT018541	Proprotein convertase subtilisin/kexin type 9	255738	reviewed	Enzyme
Q92731	BXGT019366	Estrogen receptor beta	2100	reviewed	Nuclear receptor
Q92887	BXGT019389	Canalicular multispecific organic anion transporter 1	1244	reviewed	Transporter
Q96RI1	BXGT019727	Bile acid receptor	9971	reviewed	Nuclear receptor
Q99523	BXGT019929	Sortilin	6272	reviewed	Transporter
Q99527	BXGT019930	G-protein coupled estrogen receptor 1	2852	reviewed	G-protein coupled receptor
Q9BWD1	BXGT020152	Acetyl-CoA acetyltransferase, cytosolic	39	reviewed	Enzyme
Q9H9B1	BXGT020501	Histone-lysine N-methyltransferase EHMT1	79813	reviewed	Epigenetic regulator
Q9HAW7	BXGT020508	UDP-glucuronosyltransferase 1-7	54577	reviewed
Q9HAW8	BXGT020509	UDP-glucuronosyltransferase 1-10	54575	reviewed
Q9HAW9	BXGT020510	UDP-glucuronosyltransferase 1-8	54576	reviewed
Q9HC97	BXGT020527	G-protein coupled receptor 35	2859	reviewed	G-protein coupled receptor
Q9HD67	BXGT020544	Unconventional myosin-X	4651	reviewed
Q9NR56	BXGT021179	Muscleblind-like protein 1	4154	reviewed	Nucleic acid binding
Q9NUX5	BXGT021220	Protection of telomeres protein 1	25913	reviewed	Nucleic acid binding
Q9UHC9	BXGT021696	NPC1-like intracellular cholesterol transporter 1	29881	reviewed	Transporter
Q9UIF8	BXGT021718	Bromodomain adjacent to zinc finger domain protein 2B	29994	reviewed
Q9UNQ0	BXGT021792	ATP-binding cassette sub-family G member 2	9429	reviewed	Transporter
Q9Y223	BXGT022207	Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase	10020	reviewed	Enzyme
Q9Y2Q3	BXGT022242	Glutathione S-transferase kappa 1	373156	reviewed
Q9Y694	BXGT022321	Solute carrier family 22 member 7	10864	reviewed	Transporter
Q9Y6L6	BXGT022334	Solute carrier organic anion transporter family member 1B1	10599	reviewed	Transporter
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
P25054	BXGT022961	Adenomatous polyposis coli protein	324	reviewed
Q9UK05	BXGT023094	Growth/differentiation factor 2	2658	reviewed	Signaling
Q96QC4	BXGT023878	MHC class I polypeptide-related sequence A	100507436	unreviewed
Q9HBB8	BXGT025060	Cadherin-related family member 5	53841	reviewed
P51608	BXGT025073	Methyl-CpG-binding protein 2	4204	reviewed	Epigenetic regulator
P35250	BXGT025854	Replication factor C subunit 2	5982	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}