adisease

Showing entry for Alcohol abuse

General Disease Information
BXGD Id	BXGD003251
Disease Name	Alcohol abuse
Disease CUI Id	C0085762
MeSH Codes	C25 F03
Disease Class Name	Chemically-Induced Disorders; Mental Disorders
Semantic Type	Mental or Behavioral Dysfunction
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:150
Disease Ontology Class Name	disease of mental health
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00519	BXGT003934	Fatty-acid amide hydrolase 1	2166	reviewed
O14594	BXGT004073	Neurocan core protein	1463	reviewed	Extracellular structure
O15455	BXGT004171	Toll-like receptor 3	7098	reviewed	Receptor
O43175	BXGT004575	D-3-phosphoglycerate dehydrogenase	26227	reviewed	Enzyme
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O60755	BXGT004898	Galanin receptor type 3	8484	reviewed	G-protein coupled receptor
P00325	BXGT005498	Alcohol dehydrogenase 1B	125	reviewed	Enzyme
P00326	BXGT005499	Alcohol dehydrogenase 1C	126	reviewed	Enzyme
P00352	BXGT005510	Retinal dehydrogenase 1	216	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00734	BXGT005630	Prothrombin	2147	reviewed	Enzyme
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01130	BXGT005735	Low-density lipoprotein receptor	3949	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01303	BXGT005748	Pro-neuropeptide Y	4852	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P02786	BXGT005961	Transferrin receptor protein 1	7037	reviewed	Enzyme
P02787	BXGT005962	Serotransferrin	7018	reviewed	Enzyme
P03956	BXGT006120	Interstitial collagenase	4312	reviewed	Enzyme
P04150	BXGT006154	Glucocorticoid receptor	2908	reviewed	Nuclear receptor
P04278	BXGT006182	Sex hormone-binding globulin	6462	reviewed
P05091	BXGT006312	Aldehyde dehydrogenase, mitochondrial	217	reviewed	Enzyme
P05181	BXGT006337	Cytochrome P450 2E1	1571	reviewed
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06241	BXGT006429	Tyrosine-protein kinase Fyn	2534	reviewed	Kinase
P06850	BXGT006511	Corticoliberin	1392	reviewed	Signaling
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08319	BXGT006764	Alcohol dehydrogenase 4	127	reviewed	Enzyme
P08684	BXGT006812	Cytochrome P450 3A4	1576	reviewed	Enzyme
P08908	BXGT006837	5-hydroxytryptamine receptor 1A	3350	reviewed	G-protein coupled receptor
P09525	BXGT006901	Annexin A4	307	reviewed
P11766	BXGT007745	Alcohol dehydrogenase class-3	128	reviewed	Enzyme
P12643	BXGT007830	Bone morphogenetic protein 2	650	reviewed	Signaling
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P14416	BXGT008011	D(2) dopamine receptor	1813	reviewed	G-protein coupled receptor
P14550	BXGT008019	Aldo-keto reductase family 1 member A1	10327	reviewed	Enzyme
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P14867	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	2554	reviewed	Ion channel
P16442	BXGT008227	Histo-blood group ABO system transferase	28	reviewed	Enzyme
P16455	BXGT008229	Methylated-DNA--protein-cysteine methyltransferase	4255	reviewed
P18507	BXGT008411	Gamma-aminobutyric acid receptor subunit gamma-2	2566	reviewed	Ion channel
P19440	BXGT008481	Glutathione hydrolase 1 proenzyme	2678	reviewed	Enzyme
P20815	BXGT008604	Cytochrome P450 3A5	1577	reviewed	Enzyme
P21397	BXGT008644	Amine oxidase [flavin-containing] A	4128	reviewed
P21554	BXGT008662	Cannabinoid receptor 1	1268	reviewed	G-protein coupled receptor
P21917	BXGT008707	D(4) dopamine receptor	1815	reviewed	G-protein coupled receptor
P21964	BXGT008714	Catechol O-methyltransferase	1312	reviewed	Enzyme
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P25103	BXGT009020	Substance-P receptor	6869	reviewed	G-protein coupled receptor
P27815	BXGT009208	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	5141	reviewed
P28222	BXGT009238	5-hydroxytryptamine receptor 1B	3351	reviewed	G-protein coupled receptor
P28223	BXGT009239	5-hydroxytryptamine receptor 2A	3356	reviewed	G-protein coupled receptor
P28472	BXGT009260	Gamma-aminobutyric acid receptor subunit beta-3	2562	reviewed	Ion channel
P29401	BXGT009344	Transketolase	7086	reviewed	Enzyme
P30532	BXGT009433	Neuronal acetylcholine receptor subunit alpha-5	1138	reviewed	Ion channel
P30559	BXGT009442	Oxytocin receptor	5021	reviewed	G-protein coupled receptor
P31645	BXGT009558	Sodium-dependent serotonin transporter	6532	reviewed	Transporter
P32238	BXGT009611	Cholecystokinin receptor type A	886	reviewed	G-protein coupled receptor
P32297	BXGT009616	Neuronal acetylcholine receptor subunit alpha-3	1136	reviewed	Ion channel
P34972	BXGT009779	Cannabinoid receptor 2	1269	reviewed	G-protein coupled receptor
P34998	BXGT009781	Corticotropin-releasing factor receptor 1	1394	reviewed
P35372	BXGT009823	Mu-type opioid receptor	4988	reviewed	G-protein coupled receptor
P35462	BXGT009835	D(3) dopamine receptor	1814	reviewed	G-protein coupled receptor
P37840	BXGT010015	Alpha-synuclein	6622	reviewed	Transporter
P41146	BXGT010226	Nociceptin receptor	4987	reviewed	G-protein coupled receptor
P47869	BXGT010590	Gamma-aminobutyric acid receptor subunit alpha-2	2555	reviewed	Ion channel
P47989	BXGT010602	Xanthine dehydrogenase/oxidase	7498	reviewed	Enzyme
P48051	BXGT010611	G protein-activated inward rectifier potassium channel 2	3763	reviewed	Ion channel
P49146	BXGT010681	Neuropeptide Y receptor type 2	4887	reviewed	G-protein coupled receptor
P52788	BXGT010953	Spermine synthase	6611	reviewed
P53355	BXGT010985	Death-associated protein kinase 1	1612	reviewed	Kinase
P60033	BXGT011286	CD81 antigen	975	reviewed
P81172	BXGT011935	Hepcidin	57817	reviewed
Q01959	BXGT012624	Sodium-dependent dopamine transporter	6531	reviewed	Transporter
Q07343	BXGT012926	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	5142	reviewed
Q13451	BXGT013356	Peptidyl-prolyl cis-trans isomerase FKBP5	2289	reviewed	Enzyme
Q13936	BXGT013404	Voltage-dependent L-type calcium channel subunit alpha-1C	775	reviewed	Ion channel
Q15761	BXGT013596	Neuropeptide Y receptor type 5	4889	reviewed	G-protein coupled receptor
Q15796	BXGT013599	Mothers against decapentaplegic homolog 2	4087	reviewed	Transcription factor
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q30201	BXGT014297	Hereditary hemochromatosis protein	3077	reviewed
Q86TM3	BXGT017607	Probable ATP-dependent RNA helicase DDX53	168400	reviewed
Q8NBP7	BXGT018541	Proprotein convertase subtilisin/kexin type 9	255738	reviewed	Enzyme
Q8NFD2	BXGT018559	Ankyrin repeat and protein kinase domain-containing protein 1	255239	reviewed	Kinase
Q8TDS5	BXGT018813	Oxoeicosanoid receptor 1	165140	reviewed	G-protein coupled receptor
Q8TDV0	BXGT018815	Probable G-protein coupled receptor 151	134391	reviewed	G-protein coupled receptor
Q92769	BXGT019370	Histone deacetylase 2	3066	reviewed	Epigenetic regulator
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q99895	BXGT019974	Chymotrypsin-C	11330	reviewed
Q9C0B1	BXGT020209	Alpha-ketoglutarate-dependent dioxygenase FTO	79068	reviewed
Q9NQX3	BXGT021172	Gephyrin	10243	reviewed
Q9UBS5	BXGT021662	Gamma-aminobutyric acid type B receptor subunit 1	2550	reviewed	G-protein coupled receptor
Q9UHC9	BXGT021696	NPC1-like intracellular cholesterol transporter 1	29881	reviewed	Transporter
Q9ULV1	BXGT021764	Frizzled-4	8322	reviewed	G-protein coupled receptor
Q9Y243	BXGT022214	RAC-gamma serine/threonine-protein kinase	10000	reviewed	Kinase
Q92847	BXGT022673	Growth hormone secretagogue receptor type 1	2693	reviewed	G-protein coupled receptor
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
O43613	BXGT025666	Orexin receptor type 1	3061	reviewed	G-protein coupled receptor
Q8IZL9	BXGT026139	Cyclin-dependent kinase 20	23552	reviewed	Kinase
Q08477	BXGT026164	Docosahexaenoic acid omega-hydroxylase CYP4F3	4051	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}