Showing entry for Glutaminase liver isoform, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021711
Protein NameGlutaminase liver isoform, mitochondrial
Uniport IdQ9UI32
GeneGLS2
Gene Id27165
DomainAnk_2; EF-hand_14; Glutaminase
Pfam PF12796   PF17959   PF04960  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00220 Arginine biosynthesis
1. Metabolism 1.5 Amino acid metabolism hsa00250 Alanine, aspartate and glutamate metabolism
1. Metabolism 1.6 Metabolism of other amino acids hsa00471 D-Glutamine and D-glutamate metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
5. Organismal Systems 5.6 Nervous system hsa04724 Glutamatergic synapse
5. Organismal Systems 5.6 Nervous system hsa04727 GABAergic synapse
5. Organismal Systems 5.5 Excretory system hsa04964 Proximal tubule bicarbonate reclamation
6. Human Diseases 6.1 Cancers: Overview hsa05206 MicroRNAs in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05230 Central carbon metabolism in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008652 cellular amino acid biosynthetic process
Biological Process GO:0006520 cellular amino acid metabolic process
Biological Process GO:0006537 glutamate biosynthetic process
Biological Process GO:0014047 glutamate secretion
Biological Process GO:0006543 glutamine catabolic process
Biological Process GO:0072593 reactive oxygen species metabolic process
Biological Process GO:0042981 regulation of apoptotic process
molecular function GO:0004359 glutaminase activity
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005739 mitochondrion
Reactome
Pathway Id Pathway Name
R-HSA-112310 Neurotransmitter release cycle
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-1430728 Metabolism
R-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-212436 Generic Transcription Pathway
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8964539 Glutamate and glutamine metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001430 BXGD000054 Adenoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004114 BXGD000255 Astrocytoma Neoplasms
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007138 BXGD000446 Carcinoma, Transitional Cell Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014474 BXGD000917 Ependymoma Neoplasms
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019151 BXGD001290 Hepatic Encephalopathy Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028945 BXGD002099 oligodendroglioma Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0201874 BXGD004054 Amino acids measurement
C0202202 BXGD004082 Protein measurement
C0205768 BXGD004119 Subependymal Giant Cell Astrocytoma Neoplasms
C0206716 BXGD004262 Ganglioglioma Neoplasms
C0220810 BXGD004346 Congenital defects
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0278874 BXGD006605 Adult Ependymoma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279070 BXGD006625 Adult Oligodendroglioma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0280475 BXGD006749 Childhood Oligodendroglioma Neoplasms
C0302274 BXGD006835 Glutamine measurement
C0337438 BXGD007159 Glucose measurement
C0338106 BXGD007167 Adenocarcinoma of colon Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0428568 BXGD008633 Fasting blood glucose measurement
C0495706 BXGD009038 elevated blood glucose level
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0523465 BXGD009209 Serum albumin measurement
C0523677 BXGD009215 Glycine measurement
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751396 BXGD010425 Well Differentiated Oligodendroglioma Neoplasms
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0796611 BXGD010835 Newly Diagnosed Childhood Ependymoma Neoplasms
C0852036 BXGD010934 Pregnancy associated hypertension Female Urogenital Diseases and Pregnancy Complications; Cardiovascular Diseases
C0869220 BXGD011305 Adverse effects, not elsewhere classified
C1142423 BXGD011753 Bacteremia due to Staphylococcus aureus Pathological Conditions, Signs and Symptoms; Infections
C1261430 BXGD011853 Fasting blood sugar result
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1314694 BXGD012389 Astrocytoma, low grade Neoplasms
C1332969 BXGD012567 Childhood Ganglioglioma Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1851584 BXGD015221 Childhood Ependymoma Neoplasms
C2145472 BXGD016931 Urothelial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3828492 BXGD019743 Pre-Gestational Diabetes Nutritional and Metabolic Diseases; Endocrine System Diseases
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4237343 BXGD022309 Overweight or obesity
C4510110 BXGD022981 Habitual snoring Pathological Conditions, Signs and Symptoms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
BXGC0006162 L-Glutamic acid 147.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein