Showing entry for Long-chain-fatty-acid--CoA ligase 5


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021758
Protein NameLong-chain-fatty-acid--CoA ligase 5
Uniport IdQ9ULC5
GeneACSL5
Gene Id51703
DomainAMP-binding
Pfam PF00501  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00061 Fatty acid biosynthesis
1. Metabolism 1.3 Lipid metabolism hsa00071 Fatty acid degradation
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01212 Fatty acid metabolism
5. Organismal Systems 5.2 Endocrine system hsa03320 PPAR signaling pathway
4. Cellular Processes 4.1 Transport and catabolism hsa04146 Peroxisome
4. Cellular Processes 4.2 Cell growth and death hsa04216 Ferroptosis
5. Organismal Systems 5.10 Environmental adaptation hsa04714 Thermogenesis
5. Organismal Systems 5.2 Endocrine system hsa04920 Adipocytokine signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008610 lipid biosynthetic process
Biological Process GO:0001676 long-chain fatty acid metabolic process
Biological Process GO:0035338 long-chain fatty-acyl-CoA biosynthetic process
Biological Process GO:0010747 positive regulation of long-chain fatty acid import across plasma membrane
Biological Process GO:2001236 regulation of extrinsic apoptotic signaling pathway
molecular function GO:0003996 acyl-CoA ligase activity
molecular function GO:0047676 arachidonate-CoA ligase activity
molecular function GO:0005524 ATP binding
molecular function GO:0102391 decanoate-CoA ligase activity
molecular function GO:0004467 long-chain fatty acid-CoA ligase activity
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0016020 membrane
cellular component GO:0005741 mitochondrial outer membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-75105 Fatty acyl-CoA biosynthesis
R-HSA-75876 Synthesis of very long-chain fatty acyl-CoAs
R-HSA-8978868 Fatty acid metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002793 BXGD000130 Anaplasia Pathological Conditions, Signs and Symptoms; Neoplasms
C0002894 BXGD000151 Refractory anaemia with excess blasts Hemic and Lymphatic Diseases
C0003865 BXGD000232 Arthritis, Adjuvant-Induced Musculoskeletal Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0023439 BXGD001645 Leukemia, Eosinophilic, Acute Neoplasms
C0023440 BXGD001646 Acute Erythroblastic Leukemia Neoplasms; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0025568 BXGD001877 Metaplasia Pathological Conditions, Signs and Symptoms
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0200665 BXGD004045 Platelet mean volume determination (procedure)
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0279630 BXGD006661 Adult Acute Eosinophilic Leukemia Neoplasms
C0279648 BXGD006671 Childhood Acute Eosinophilic Leukemia Neoplasms
C0334037 BXGD006980 Intestinal metaplasia
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0596887 BXGD009648 mathematical ability
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0702266 BXGD009915 Basophilia
C0742343 BXGD010061 Acute Chest Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C0971858 BXGD011594 Arthritis, Collagen-Induced Musculoskeletal Diseases
C0993582 BXGD011596 Arthritis, Experimental Musculoskeletal Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1368683 BXGD012900 Epithelioma Neoplasms
C1535510 BXGD013319 ADENOMAS AND ADENOCARCINOMAS Neoplasms
C1561826 BXGD013364 Overweight and obesity
C1569637 BXGD013424 Adenocarcinoma, Endometrioid Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C2112532 BXGD016922 Postmenopausal endometrium
C2347761 BXGD017049 Childhood Myelodysplastic Syndrome Hemic and Lymphatic Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3900098 BXGD020106 Adult Myelodysplastic Syndrome Hemic and Lymphatic Diseases
C4529962 BXGD023178 Fatty Liver Disease
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4733092 BXGD023907 estrogen receptor-negative breast cancer
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein