Showing entry for DCC-interacting protein 13-alpha


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022975
Protein NameDCC-interacting protein 13-alpha
Uniport IdQ9UKG1
GeneAPPL1
Gene Id26060
DomainBAR_3; PH; PID
Pfam PF00169   PF00640  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.9 Aging hsa04211 Longevity regulating pathway
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05210 Colorectal cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0033211 adiponectin-activated signaling pathway
Biological Process GO:0007049 cell cycle
Biological Process GO:0035729 cellular response to hepatocyte growth factor stimulus
Biological Process GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Biological Process GO:0008286 insulin receptor signaling pathway
Biological Process GO:1905450 negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
Biological Process GO:1900017 positive regulation of cytokine production involved in inflammatory response
Biological Process GO:0046326 positive regulation of glucose import
Biological Process GO:1905303 positive regulation of macropinocytosis
Biological Process GO:0048023 positive regulation of melanin biosynthetic process
Biological Process GO:0006606 protein import into nucleus
Biological Process GO:0010762 regulation of fibroblast migration
Biological Process GO:2000045 regulation of G1/S transition of mitotic cell cycle
Biological Process GO:0046324 regulation of glucose import
Biological Process GO:0045088 regulation of innate immune response
Biological Process GO:1903076 regulation of protein localization to plasma membrane
Biological Process GO:0034143 regulation of toll-like receptor 4 signaling pathway
Biological Process GO:0023052 signaling
Biological Process GO:0007165 signal transduction
Biological Process GO:0007179 transforming growth factor beta receptor signaling pathway
molecular function GO:0048487 beta-tubulin binding
molecular function GO:0042802 identical protein binding
molecular function GO:0035091 phosphatidylinositol binding
molecular function GO:0001786 phosphatidylserine binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0043422 protein kinase B binding
cellular component GO:0005737 cytoplasm
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0005829 cytosol
cellular component GO:0005769 early endosome
cellular component GO:0031901 early endosome membrane
cellular component GO:0032009 early phagosome
cellular component GO:0005768 endosome
cellular component GO:0010008 endosome membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0097708 intracellular vesicle
cellular component GO:0044354 macropinosome
cellular component GO:0016020 membrane
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0001726 ruffle
cellular component GO:0012506 vesicle membrane
Reactome
Pathway Id Pathway Name
R-HSA-109581 Apoptosis
R-HSA-418889 Caspase activation via Dependence Receptors in the absence of ligand
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway
R-HSA-5357801 Programmed Cell Death
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0017979 BXGD001159 Glycosuria Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028756 BXGD002083 Obesity, Morbid Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028860 BXGD002093 Oculocerebrorenal Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Nervous System Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0151650 BXGD003454 Renal fibrosis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0158986 BXGD003916 Neonatal hypoglycemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206669 BXGD004229 Hepatocellular Adenoma Digestive System Diseases; Neoplasms
C0266267 BXGD005638 Congenital hypoplasia of pancreas Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0267963 BXGD005796 Exocrine pancreatic insufficiency Digestive System Diseases
C0268800 BXGD006041 Simple renal cyst Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0342273 BXGD007448 Transient neonatal diabetes mellitus
C0342276 BXGD007449 Maturity onset diabetes mellitus in young Nutritional and Metabolic Diseases; Endocrine System Diseases
C0362046 BXGD007959 Prediabetes syndrome Nutritional and Metabolic Diseases; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0497406 BXGD009064 Overweight Pathological Conditions, Signs and Symptoms
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0856169 BXGD011096 Endothelial dysfunction
C0920646 BXGD011471 Ischemia of kidney Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1847425 BXGD014865 Abnormal oral glucose tolerance
C1848395 BXGD014921 Large for gestational age Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C1864903 BXGD016270 Hyperinsulinemic hypoglycemia Nutritional and Metabolic Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1962966 BXGD016678 Retinopathy, CTCAE
C2675519 BXGD017298 Hypoadiponectinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C2748055 BXGD017583 Hypoinsulinaemia (disorder)
C3160761 BXGD018475 Diabetic dyslipidaemia
C3887499 BXGD019884 Renal cyst Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3888018 BXGD019942 Congenital Hyperinsulinism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases
C4073162 BXGD022053 Elevated hemoglobin A1c
C4225299 BXGD022214 MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 14
C4280765 BXGD022402 Abnormal C-peptide level
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein