Showing entry for E3 ubiquitin/ISG15 ligase TRIM25


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT024016
Protein NameE3 ubiquitin/ISG15 ligase TRIM25
Uniport IdQ14258
GeneTRIM25
Gene Id7706
DomainPRY; SPRY; zf-C3HC4_4
Pfam PF13765   PF00622  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04064 NF-kappa B signaling pathway
5. Organismal Systems 5.1 Immune system hsa04622 RIG-I-like receptor signaling pathway
6. Human Diseases 6.9 Infectious diseases: Viral hsa05164 Influenza A
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:1990830 cellular response to leukemia inhibitory factor
Biological Process GO:0051607 defense response to virus
Biological Process GO:0045087 innate immune response
Biological Process GO:0060333 interferon-gamma-mediated signaling pathway
Biological Process GO:0032480 negative regulation of type I interferon production
Biological Process GO:0046597 negative regulation of viral entry into host cell
Biological Process GO:1902187 negative regulation of viral release from host cell
Biological Process GO:0051091 positive regulation of DNA-binding transcription factor activity
Biological Process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:0006513 protein monoubiquitination
Biological Process GO:0046596 regulation of viral entry into host cell
Biological Process GO:1902186 regulation of viral release from host cell
Biological Process GO:0043627 response to estrogen
Biological Process GO:0033280 response to vitamin D
Biological Process GO:0019985 translesion synthesis
Biological Process GO:0030433 ubiquitin-dependent ERAD pathway
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
Biological Process GO:0016032 viral process
molecular function GO:0045296 cadherin binding
molecular function GO:0016874 ligase activity
molecular function GO:0046872 metal ion binding
molecular function GO:0039552 RIG-I binding
molecular function GO:0003723 RNA binding
molecular function GO:0061630 ubiquitin protein ligase activity
cellular component GO:0010494 cytoplasmic stress granule
cellular component GO:0005829 cytosol
cellular component GO:0016604 nuclear body
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168249 Innate Immune System
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
R-HSA-392499 Metabolism of proteins
R-HSA-5656169 Termination of translesion DNA synthesis
R-HSA-5688426 Deubiquitination
R-HSA-5689896 Ovarian tumor domain proteases
R-HSA-597592 Post-translational protein modification
R-HSA-73893 DNA Damage Bypass
R-HSA-73894 DNA Repair
R-HSA-877300 Interferon gamma signaling
R-HSA-913531 Interferon Signaling
R-HSA-918233 TRAF3-dependent IRF activation pathway
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-933542 TRAF6 mediated NF-kB activation
R-HSA-933542 TRAF6 mediated NF-kB activation
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002879 BXGD000138 Anemia, Hemolytic, Acquired Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0014170 BXGD000902 Endometrial Neoplasms Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0019061 BXGD001273 Hemolytic-Uremic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Hemic and Lymphatic Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025007 BXGD001821 Measles Infections
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0031090 BXGD002280 Periodontal Diseases Stomatognathic Diseases
C0033687 BXGD002415 Proteinuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035369 BXGD002543 Retroviridae Infections Infections
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0236734 BXGD004823 Caffeine related disorders
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278701 BXGD006566 Gastric Adenocarcinoma Digestive System Diseases; Neoplasms
C0340643 BXGD007357 Dissection of aorta Cardiovascular Diseases
C0346957 BXGD007836 Disseminated Malignant Neoplasm Neoplasms
C0375023 BXGD007970 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C1175175 BXGD011797 Severe Acute Respiratory Syndrome Infections; Respiratory Tract Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C2062441 BXGD016897 Influenza A
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2609414 BXGD017182 Acute kidney injury Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2931788 BXGD018064 Atypical Hemolytic Uremic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Hemic and Lymphatic Diseases
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3554330 BXGD019209 NEPHROTIC SYNDROME, TYPE 7
C3694279 BXGD019338 Middle East Respiratory Syndrome Infections
C3808620 BXGD019551 HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 7
C4284413 BXGD022437 Severe Fever with Thrombocytopenia Syndrome Hemic and Lymphatic Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein