Showing entry for F-box/WD repeat-containing protein 1A


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT024812
Protein NameF-box/WD repeat-containing protein 1A
Uniport IdQ9Y297
GeneBTRC
Gene Id8945
DomainBeta-TrCP_D; F-box-like; WD40
Pfam PF12125   PF12937   PF00400  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.2 Cell growth and death hsa04114 Oocyte meiosis
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04120 Ubiquitin mediated proteolysis
4. Cellular Processes 4.2 Cell growth and death hsa04218 Cellular senescence
3. Environmental Information Processing 3.2 Signal transduction hsa04310 Wnt signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04340 Hedgehog signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04390 Hippo signaling pathway
5. Organismal Systems 5.10 Environmental adaptation hsa04710 Circadian rhythm
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05131 Shigellosis
6. Human Diseases 6.9 Infectious diseases: Viral hsa05170 Human immunodeficiency virus 1 infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0060444 branching involved in mammary gland duct morphogenesis
Biological Process GO:0071407 cellular response to organic cyclic compound
Biological Process GO:0038095 Fc-epsilon receptor signaling pathway
Biological Process GO:0000086 G2/M transition of mitotic cell cycle
Biological Process GO:0070498 interleukin-1-mediated signaling pathway
Biological Process GO:0033598 mammary gland epithelial cell proliferation
Biological Process GO:0043433 negative regulation of DNA-binding transcription factor activity
Biological Process GO:0045879 negative regulation of smoothened signaling pathway
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0038061 NIK/NF-kappaB signaling
Biological Process GO:0042753 positive regulation of circadian rhythm
Biological Process GO:0045862 positive regulation of proteolysis
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:1904668 positive regulation of ubiquitin protein ligase activity
Biological Process GO:0043687 post-translational protein modification
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0006470 protein dephosphorylation
Biological Process GO:0031648 protein destabilization
Biological Process GO:0070936 protein K48-linked ubiquitination
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0060828 regulation of canonical Wnt signaling pathway
Biological Process GO:0042752 regulation of circadian rhythm
Biological Process GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:1901990 regulation of mitotic cell cycle phase transition
Biological Process GO:0061136 regulation of proteasomal protein catabolic process
Biological Process GO:0048511 rhythmic process
Biological Process GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0007165 signal transduction
Biological Process GO:0002223 stimulatory C-type lectin receptor signaling pathway
Biological Process GO:0051403 stress-activated MAPK cascade
Biological Process GO:0050852 T cell receptor signaling pathway
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
Biological Process GO:0016032 viral process
Biological Process GO:0016055 Wnt signaling pathway
molecular function GO:0008013 beta-catenin binding
molecular function GO:0016874 ligase activity
molecular function GO:0046983 protein dimerization activity
molecular function GO:0045309 protein phosphorylated amino acid binding
molecular function GO:1990757 ubiquitin ligase activator activity
molecular function GO:1990756 ubiquitin ligase-substrate adaptor activity
molecular function GO:0061630 ubiquitin protein ligase activity
cellular component GO:0005829 cytosol
cellular component GO:0005654 nucleoplasm
cellular component GO:0019005 SCF ubiquitin ligase complex
Reactome
Pathway Id Pathway Name
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
R-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1170546 Prolactin receptor signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280218 Adaptive Immune System
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-162906 HIV Infection
R-HSA-162909 Host Interactions of HIV factors
R-HSA-1640170 Cell Cycle
R-HSA-1643685 Disease
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168898 Toll-like Receptor Cascades
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase
R-HSA-180534 Vpu mediated degradation of CD4
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-195721 Signaling by WNT
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-202403 TCR signaling
R-HSA-202424 Downstream TCR signaling
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex
R-HSA-392499 Metabolism of proteins
R-HSA-400253 Circadian Clock
R-HSA-446652 Interleukin-1 family signaling
R-HSA-448424 Interleukin-17 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-450294 MAP kinase activation
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-453276 Regulation of mitotic cell cycle
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5610780 Degradation of GLI1 by the proteasome
R-HSA-5610783 Degradation of GLI2 by the proteasome
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-5663205 Infectious disease
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5676590 NIK-->noncanonical NF-kB signaling
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-HSA-597592 Post-translational protein modification
R-HSA-69275 G2/M Transition
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-8951664 Neddylation
R-HSA-9020702 Interleukin-1 signaling
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-975871 MyD88 cascade initiated on plasma membrane
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003076 BXGD000171 Aniridia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0032927 BXGD002381 Precancerous Conditions Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0037369 BXGD002691 Smoking Behavior and Behavior Mechanisms
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0206624 BXGD004190 Hepatoblastoma Neoplasms
C0206663 BXGD004225 Neuroectodermal Tumor, Primitive Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0221352 BXGD004444 Syndactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases
C0221373 BXGD004454 Claw hand Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0265554 BXGD005548 Ectrodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0265594 BXGD005553 Congenital absence of hand Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0424574 BXGD008534 Duration of sleep
C0426868 BXGD008591 Absence of hand
C0427460 BXGD008616 Red cell distribution width determination
C0428883 BXGD008639 Diastolic blood pressure
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0728895 BXGD009919 Absent finger Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1269955 BXGD012005 Tumor Cell Invasion
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332201 BXGD012502 Adult Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1838652 BXGD014330 SPLIT-HAND/FOOT MALFORMATION 3 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3887496 BXGD019882 Oligodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4721806 BXGD023772 Carcinoma, Basal Cell Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000441 Dimethyl sulfoxide 78.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein