adisease

Showing entry for Sleep Disorders

General Disease Information
BXGD Id	BXGD010925
Disease Name	Sleep Disorders
Disease CUI Id	C0851578
MeSH Codes	C23 C10 F03
Disease Class Name	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
Semantic Type	Mental or Behavioral Dysfunction
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
F7VJQ1	BXGT003310	Alternative prion protein	5621	reviewed
O00767	BXGT003949	Acyl-CoA desaturase	6319	reviewed
O14936	BXGT004114	Peripheral plasma membrane protein CASK	8573	reviewed	Kinase
O14980	BXGT004119	Exportin-1	7514	reviewed	Receptor
O43612	BXGT004605	Orexin	3060	reviewed
O43614	BXGT004606	Orexin receptor type 2	3062	reviewed	G-protein coupled receptor
O43766	BXGT004622	Lipoyl synthase, mitochondrial	11019	reviewed
O75369	BXGT005119	Filamin-B	2317	reviewed
O75475	BXGT005130	PC4 and SFRS1-interacting protein	11168	reviewed	Signaling
O75628	BXGT005140	GTP-binding protein REM 1	28954	reviewed
O75899	BXGT005161	Gamma-aminobutyric acid type B receptor subunit 2	9568	reviewed	G-protein coupled receptor
O76039	BXGT005171	Cyclin-dependent kinase-like 5	6792	reviewed	Kinase
O76054	BXGT005172	SEC14-like protein 2	23541	reviewed
O95278	BXGT005370	Laforin	7957	reviewed
O95831	BXGT005399	Apoptosis-inducing factor 1, mitochondrial	9131	reviewed	Enzyme
O95970	BXGT005409	Leucine-rich glioma-inactivated protein 1	9211	reviewed
P00326	BXGT005499	Alcohol dehydrogenase 1C	126	reviewed	Enzyme
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P00915	BXGT005689	Carbonic anhydrase 1	759	reviewed
P01034	BXGT005721	Cystatin-C	1471	reviewed
P01112	BXGT005732	GTPase HRas	3265	reviewed	Enzyme modulator
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01236	BXGT005744	Prolactin	5617	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01920	BXGT005817	HLA class II histocompatibility antigen, DQ beta 1 chain	3119	reviewed	Immune response
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02774	BXGT005959	Vitamin D-binding protein	2638	reviewed	Transporter
P02795	BXGT005968	Metallothionein-2	4502	reviewed
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04062	BXGT006140	Lysosomal acid glucosylceramidase	2629	reviewed
P04150	BXGT006154	Glucocorticoid receptor	2908	reviewed	Nuclear receptor
P04156	BXGT006156	Major prion protein	5621	reviewed
P04181	BXGT006165	Ornithine aminotransferase, mitochondrial	4942	reviewed	Enzyme
P05091	BXGT006312	Aldehyde dehydrogenase, mitochondrial	217	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06276	BXGT006430	Cholinesterase	590	reviewed
P06850	BXGT006511	Corticoliberin	1392	reviewed	Signaling
P07202	BXGT006565	Thyroid peroxidase	7173	reviewed	Enzyme
P07333	BXGT006602	Macrophage colony-stimulating factor 1 receptor	1436	reviewed	Kinase
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P09172	BXGT006865	Dopamine beta-hydroxylase	1621	reviewed
P10070	BXGT007534	Zinc finger protein GLI2	2736	reviewed
P10636	BXGT007596	Microtubule-associated protein tau	4137	reviewed
P10827	BXGT007623	Thyroid hormone receptor alpha	7067	reviewed	Nuclear receptor
P10828	BXGT007624	Thyroid hormone receptor beta	7068	reviewed	Nuclear receptor
P11166	BXGT007661	Solute carrier family 2, facilitated glucose transporter member 1	6513	reviewed	Transporter
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P13236	BXGT007891	C-C motif chemokine 4	6351	reviewed
P15311	BXGT008106	Ezrin	7430	reviewed	Cellular structure
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16473	BXGT008234	Thyrotropin receptor	7253	reviewed	G-protein coupled receptor
P17787	BXGT008341	Neuronal acetylcholine receptor subunit beta-2	1141	reviewed	Ion channel
P17948	BXGT008358	Vascular endothelial growth factor receptor 1	2321	reviewed	Kinase
P18089	BXGT008379	Alpha-2B adrenergic receptor	151	reviewed	G-protein coupled receptor
P19113	BXGT008458	Histidine decarboxylase	3067	reviewed
P20711	BXGT008594	Aromatic-L-amino-acid decarboxylase	1644	reviewed
P20930	BXGT008616	Filaggrin	2312	reviewed	Cellular structure
P20933	BXGT008618	N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	175	reviewed	Enzyme
P21397	BXGT008644	Amine oxidase [flavin-containing] A	4128	reviewed
P21728	BXGT008686	D(1A) dopamine receptor	1812	reviewed	G-protein coupled receptor
P21917	BXGT008707	D(4) dopamine receptor	1815	reviewed	G-protein coupled receptor
P21964	BXGT008714	Catechol O-methyltransferase	1312	reviewed	Enzyme
P22303	BXGT008751	Acetylcholinesterase	43	reviewed	Enzyme
P22304	BXGT008752	Iduronate 2-sulfatase	3423	reviewed
P23415	BXGT008864	Glycine receptor subunit alpha-1	2741	reviewed	Ion channel
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P25101	BXGT009018	Endothelin-1 receptor	1909	reviewed	G-protein coupled receptor
P25440	BXGT009044	Bromodomain-containing protein 2	6046	reviewed	Epigenetic regulator
P30542	BXGT009436	Adenosine receptor A1	134	reviewed	G-protein coupled receptor
P30793	BXGT009466	GTP cyclohydrolase 1	2643	reviewed	Enzyme
P31391	BXGT009535	Somatostatin receptor type 4	6754	reviewed	G-protein coupled receptor
P31645	BXGT009558	Sodium-dependent serotonin transporter	6532	reviewed	Transporter
P34969	BXGT009777	5-hydroxytryptamine receptor 7	3363	reviewed	G-protein coupled receptor
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35270	BXGT009807	Sepiapterin reductase	6697	reviewed
P35348	BXGT009814	Alpha-1A adrenergic receptor	148	reviewed	G-protein coupled receptor
P35462	BXGT009835	D(3) dopamine receptor	1814	reviewed	G-protein coupled receptor
P35475	BXGT009837	Alpha-L-iduronidase	3425	reviewed	Enzyme
P35498	BXGT009838	Sodium channel protein type 1 subunit alpha	6323	reviewed	Ion channel
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P37288	BXGT009977	Vasopressin V1a receptor	552	reviewed	G-protein coupled receptor
P37840	BXGT010015	Alpha-synuclein	6622	reviewed	Transporter
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42658	BXGT010327	Dipeptidyl aminopeptidase-like protein 6	1804	reviewed	Enzyme
P43354	BXGT010381	Nuclear receptor subfamily 4 group A member 2	4929	reviewed	Nuclear receptor
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	1137	reviewed	Ion channel
P45381	BXGT010460	Aspartoacylase	443	reviewed
P48167	BXGT010621	Glycine receptor subunit beta	2743	reviewed	Ion channel
P49286	BXGT010691	Melatonin receptor type 1B	4544	reviewed	G-protein coupled receptor
P49448	BXGT010709	Glutamate dehydrogenase 2, mitochondrial	2747	reviewed	Enzyme
P49591	BXGT010715	Serine--tRNA ligase, cytoplasmic	6301	reviewed	Enzyme
P49674	BXGT010725	Casein kinase I isoform epsilon	1454	reviewed
P50135	BXGT010776	Histamine N-methyltransferase	3176	reviewed
P50897	BXGT010823	Palmitoyl-protein thioesterase 1	5538	reviewed	Enzyme
P51688	BXGT010883	N-sulphoglucosamine sulphohydrolase	6448	reviewed	Enzyme
P54802	BXGT011081	Alpha-N-acetylglucosaminidase	4669	reviewed
P55957	BXGT011137	BH3-interacting domain death agonist	637	reviewed
P56524	BXGT011176	Histone deacetylase 4	9759	reviewed	Epigenetic regulator
P56537	BXGT011177	Eukaryotic translation initiation factor 6	3692	reviewed	Nucleic acid binding
P57059	BXGT011210	Serine/threonine-protein kinase SIK1	150094	reviewed
P60174	BXGT011294	Triosephosphate isomerase	7167	reviewed	Enzyme
P98164	BXGT012230	Low-density lipoprotein receptor-related protein 2	4036	reviewed
Q00604	BXGT012538	Norrin	4693	reviewed
Q00653	BXGT012541	Nuclear factor NF-kappa-B p100 subunit	4791	reviewed	Transcription factor
Q01959	BXGT012624	Sodium-dependent dopamine transporter	6531	reviewed	Transporter
Q02790	BXGT012672	Peptidyl-prolyl cis-trans isomerase FKBP4	2288	reviewed	Enzyme
Q03164	BXGT012700	Histone-lysine N-methyltransferase 2A	4297	reviewed
Q04637	BXGT012771	Eukaryotic translation initiation factor 4 gamma 1	1981	reviewed	Nucleic acid binding
Q05940	BXGT012846	Synaptic vesicular amine transporter	6571	reviewed	Transporter
Q06710	BXGT012887	Paired box protein Pax-8	7849	reviewed
Q06787	BXGT012890	Synaptic functional regulator FMR1	2332	reviewed	Nucleic acid binding
Q07869	BXGT012945	Peroxisome proliferator-activated receptor alpha	5465	reviewed	Nuclear receptor
Q09470	BXGT013037	Potassium voltage-gated channel subfamily A member 1	3736	reviewed	Ion channel
Q11203	BXGT013218	CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase	6487	reviewed
Q13002	BXGT013303	Glutamate receptor ionotropic, kainate 2	2898	reviewed	Ion channel
Q13451	BXGT013356	Peptidyl-prolyl cis-trans isomerase FKBP5	2289	reviewed	Enzyme
Q13936	BXGT013404	Voltage-dependent L-type calcium channel subunit alpha-1C	775	reviewed	Ion channel
Q14203	BXGT013455	Dynactin subunit 1	1639	reviewed	Chaperone
Q14524	BXGT013478	Sodium channel protein type 5 subunit alpha	6331	reviewed	Ion channel
Q14654	BXGT013495	ATP-sensitive inward rectifier potassium channel 11	3767	reviewed	Ion channel
Q14683	BXGT013500	Structural maintenance of chromosomes protein 1A	8243	reviewed
Q30154	BXGT014296	HLA class II histocompatibility antigen, DR beta 5 chain	3127	reviewed	Immune response
Q5S007	BXGT015650	Leucine-rich repeat serine/threonine-protein kinase 2	120892	reviewed	Kinase
Q5Y7D3	BXGT015912	HLA class II histocompatibility antigen DQ beta chain	3119	unreviewed
Q6NVY1	BXGT016432	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	26275	reviewed	Enzyme
Q8IVA8	BXGT018342	Glutamate decarboxylase 1 (Brain, 67kDa)	2571	unreviewed
Q8TDS5	BXGT018813	Oxoeicosanoid receptor 1	165140	reviewed	G-protein coupled receptor
Q8TDV0	BXGT018815	Probable G-protein coupled receptor 151	134391	reviewed	G-protein coupled receptor
Q92993	BXGT019403	Histone acetyltransferase KAT5	10524	reviewed
Q96D42	BXGT019636	Hepatitis A virus cellular receptor 1	26762	reviewed
Q96EN8	BXGT019649	Molybdenum cofactor sulfurase	55034	reviewed
Q96QK1	BXGT019720	Vacuolar protein sorting-associated protein 35	55737	reviewed	Transporter
Q96RJ0	BXGT019728	Trace amine-associated receptor 1	134864	reviewed	G-protein coupled receptor
Q96SW2	BXGT019743	Protein cereblon	51185	reviewed	Enzyme
Q96T60	BXGT019745	Bifunctional polynucleotide phosphatase/kinase	11284	reviewed
Q99250	BXGT019913	Sodium channel protein type 2 subunit alpha	6326	reviewed	Ion channel
Q99259	BXGT019915	Glutamate decarboxylase 1	2571	reviewed	Enzyme
Q99572	BXGT019935	P2X purinoceptor 7	5027	reviewed	Ion channel
Q99700	BXGT019949	Ataxin-2	6311	reviewed	Nucleic acid binding
Q99808	BXGT019964	Equilibrative nucleoside transporter 1	2030	reviewed	Transporter
Q9BY41	BXGT020180	Histone deacetylase 8	55869	reviewed	Epigenetic regulator
Q9H251	BXGT020449	Cadherin-23	64072	reviewed
Q9H9B1	BXGT020501	Histone-lysine N-methyltransferase EHMT1	79813	reviewed	Epigenetic regulator
Q9HD40	BXGT020542	O-phosphoseryl-tRNA(Sec) selenium transferase	51091	reviewed
Q9NQX3	BXGT021172	Gephyrin	10243	reviewed
Q9NYL2	BXGT021259	Mitogen-activated protein kinase kinase kinase 20	51776	reviewed	Kinase
Q9UDY8	BXGT021670	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	10892	reviewed	Enzyme
Q9UGL1	BXGT021685	Lysine-specific demethylase 5B	10765	reviewed	Epigenetic regulator
Q9UGM6	BXGT021687	Tryptophan--tRNA ligase, mitochondrial	10352	reviewed
Q9UHD8	BXGT021698	Septin-9	10801	reviewed	Enzyme modulator
Q9UKE5	BXGT021741	TRAF2 and NCK-interacting protein kinase	23043	reviewed	Kinase
Q9UKM7	BXGT021747	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	11253	reviewed	Chaperone
Q9UKU7	BXGT021749	Isobutyryl-CoA dehydrogenase, mitochondrial	27034	reviewed	Enzyme
Q9ULV1	BXGT021764	Frizzled-4	8322	reviewed	G-protein coupled receptor
Q9Y2W7	BXGT022250	Calsenilin	30818	reviewed	Ion channel
Q9Y3I1	BXGT022260	F-box only protein 7	25793	reviewed
Q9Y5N1	BXGT022297	Histamine H3 receptor	11255	reviewed	G-protein coupled receptor
Q96C86	BXGT022803	m7GpppX diphosphatase	28960	reviewed	Enzyme
Q9UNS1	BXGT022882	Protein timeless homolog	8914	reviewed
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
A6NGN9	BXGT023893	IgLON family member 5	402665	reviewed
Q9Y297	BXGT024812	F-box/WD repeat-containing protein 1A	8945	reviewed
P51608	BXGT025073	Methyl-CpG-binding protein 2	4204	reviewed	Epigenetic regulator
O43613	BXGT025666	Orexin receptor type 1	3061	reviewed	G-protein coupled receptor
Q9UQE7	BXGT025899	Structural maintenance of chromosomes protein 3	9126	reviewed
P09471	BXGT026153	Guanine nucleotide-binding protein G(o) subunit alpha	2775	reviewed	Enzyme modulator

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}