Showing entry for Calsequestrin-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT025138
Protein NameCalsequestrin-2
Uniport IdO14958
GeneCASQ2
Gene Id845
DomainCalsequestrin
Pfam PF01216  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04260 Cardiac muscle contraction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0071313 cellular response to caffeine
Biological Process GO:0005513 detection of calcium ion
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:1901017 negative regulation of potassium ion transmembrane transporter activity
Biological Process GO:0043267 negative regulation of potassium ion transport
Biological Process GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
Biological Process GO:0051258 protein polymerization
Biological Process GO:0086029 Purkinje myocyte to ventricular cardiac muscle cell signaling
Biological Process GO:1903779 regulation of cardiac conduction
Biological Process GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
Biological Process GO:0010649 regulation of cell communication by electrical coupling
Biological Process GO:0002027 regulation of heart rate
Biological Process GO:0060306 regulation of membrane repolarization
Biological Process GO:0051279 regulation of release of sequestered calcium ion into cytosol
Biological Process GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Biological Process GO:0045214 sarcomere organization
Biological Process GO:0051208 sequestering of calcium ion
Biological Process GO:0006941 striated muscle contraction
molecular function GO:0048306 calcium-dependent protein binding
molecular function GO:0005509 calcium ion binding
molecular function GO:0042803 protein homodimerization activity
cellular component GO:0034704 calcium channel complex
cellular component GO:0005737 cytoplasm
cellular component GO:0030314 junctional membrane complex
cellular component GO:0014701 junctional sarcoplasmic reticulum membrane
cellular component GO:0016529 sarcoplasmic reticulum
cellular component GO:0033018 sarcoplasmic reticulum lumen
cellular component GO:0033017 sarcoplasmic reticulum membrane
cellular component GO:0030018 Z disc
Reactome
Pathway Id Pathway Name
R-HSA-2672351 Stimuli-sensing channels
R-HSA-382551 Transport of small molecules
R-HSA-397014 Muscle contraction
R-HSA-5576891 Cardiac conduction
R-HSA-5578775 Ion homeostasis
R-HSA-983712 Ion channel transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003499 BXGD000201 Supravalvular aortic stenosis Cardiovascular Diseases
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011071 BXGD000696 Sudden death Pathological Conditions, Signs and Symptoms
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018803 BXGD001228 Heart Function Tests
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0033626 BXGD002412 Protein Deficiency Nutritional and Metabolic Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039070 BXGD002787 Syncope Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042514 BXGD002989 Tachycardia, Ventricular Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0085298 BXGD003155 Sudden Cardiac Death Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085612 BXGD003204 Ventricular arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151636 BXGD003451 Premature ventricular contractions Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0235480 BXGD004751 Paroxysmal atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0334463 BXGD007076 Malignant Fibrous Histiocytoma Neoplasms
C0339143 BXGD007226 Thyroid associated opthalmopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0340485 BXGD007334 Familial ventricular tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0344432 BXGD007670 Ventricular tachycardia, polymorphic Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0428977 BXGD008644 Bradycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0429097 BXGD008648 QRS complex feature
C0751534 BXGD010494 Syncopal Episode Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0853897 BXGD010985 Diabetic Cardiomyopathies Endocrine System Diseases; Cardiovascular Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1631597 BXGD013480 VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder) Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1851710 BXGD015226 LATERAL MENINGOCELE SYNDROME Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1863753 BXGD016197 LIMB-MAMMARY SYNDROME Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1963282 BXGD016691 Wolff-Parkinson-White Syndrome, CTCAE
C2585653 BXGD017139 Persistent atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C2677794 BXGD017388 Stress-induced polymorphic ventricular tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C3468561 BXGD018908 familial atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein