Showing entry for Piperine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0000203
Compound NamePiperine
Structure
FormulaC17H19NO3
InchiKeyMXXWOMGUGJBKIW-YPCIICBESA-N
SMILESO=C(\C=C\C=C\C1=CC2=C(OCO2)C=C1)N1CCCCC1
InchiInChI=1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+
IUPAC(2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one
Molecular Weight285.34
Pubchem Id638024
Chembl IdCHEMBL43185
Targets of Information Source
DrugBank DB12582
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
O75469 BXGT005128 Nuclear receptor subfamily 1 group I member 2 reviewed Nuclear receptor NR1I2 investigational -
PDB AYR
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Q02127 BXGT012635 Dihydroorotate dehydrogenase (quinone), mitochondrial reviewed DHODH Enzyme - - - -
Binding DB 50148573
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT005689 Carbonic anhydrase 1 reviewed CA1 - 60000000 - -
reviewed BXGT005690 Carbonic anhydrase 2 reviewed CA2 - 2000000 - -
reviewed BXGT017924 Amine oxidase [flavin-containing] B reviewed Maob 3190 - - -
reviewed BXGT008643 Amine oxidase [flavin-containing] A reviewed Maoa 49300 - - -
reviewed BXGT008505 Amine oxidase [flavin-containing] B reviewed Maob 91300 - - -
reviewed BXGT016109 Amine oxidase [flavin-containing] A reviewed Maoa 19000 - - -
reviewed BXGT008643 Amine oxidase [flavin-containing] A reviewed Maoa - 404 - -
reviewed BXGT008505 Amine oxidase [flavin-containing] B reviewed Maob - 260 - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 - 15500 - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 - 74100 - -
reviewed BXGT009172 Amine oxidase [flavin-containing] B reviewed MAOB - 483 - -
reviewed BXGT008644 Amine oxidase [flavin-containing] A reviewed MAOA - 58980 - -
reviewed BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 - - - 3162.28
CHEMBL CHEMBL43185
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P07339 BXGT006604 Cathepsin D reviewed Enzyme CTSD IC50 '=' 42300 nM
P0A0J7 BXGT006970 Quinolone resistance protein NorA reviewed - norA PF '=' 60 -
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG Potency - 50118 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 14125 nM
P19643 BXGT008505 Amine oxidase [flavin-containing] B reviewed - Maob Ki '=' 91300 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 31622 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 39810 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 97 %
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 20596 nM
P21396 BXGT008643 Amine oxidase [flavin-containing] A reviewed - Maoa Ki '=' 49300 nM
Q9R1A7 BXGT021413 Nuclear receptor subfamily 1 group I member 2 reviewed - Nr1i2 Potency - 7079 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 74100 nM
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG Potency - 39810 nM
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 Activity '=' 10 uM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 12589 nM
P21396 BXGT008643 Amine oxidase [flavin-containing] A reviewed - Maoa IC50 '=' 404 nM
P19643 BXGT008505 Amine oxidase [flavin-containing] B reviewed - Maob IC50 '=' 260 nM
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 EC50 '=' 3162 nM
P0A0J7 BXGT006970 Quinolone resistance protein NorA reviewed - norA logPF '=' 1 -
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 39810 nM
P00811 BXGT005666 Beta-lactamase reviewed - ampC Potency '=' 44668 nM
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 reviewed Transporter NPC1 Potency '=' 2511 nM
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 Activity - - -
P18507 BXGT008411 Gamma-aminobutyric acid receptor subunit gamma-2 reviewed Ion channel GABRG2 Imax '=' 302 %
P47870 BXGT010591 Gamma-aminobutyric acid receptor subunit beta-2 reviewed Ion channel GABRB2 Imax '=' 302 %
P14867 BXGT008061 Gamma-aminobutyric acid receptor subunit alpha-1 reviewed Ion channel GABRA1 Imax '=' 302 %
P35869 BXGT009877 Aryl hydrocarbon receptor reviewed Transcription factor AHR Potency - 14125 nM
P0A0J7 BXGT006970 Quinolone resistance protein NorA reviewed - norA MIC '=' 2 ug.mL-1
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 15848 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 15500 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 '=' 58980 nM
P0A0J7 BXGT006970 Quinolone resistance protein NorA reviewed - norA FC '=' 2 -
Q8BW75 BXGT017924 Amine oxidase [flavin-containing] B reviewed - Maob Ki '=' 3190 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 2433 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 89125 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 - - -
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 39810 nM
P38398 BXGT010037 Breast cancer type 1 susceptibility protein reviewed Enzyme BRCA1 Potency - 8912 nM
P0A0J7 BXGT006970 Quinolone resistance protein NorA reviewed - norA MIC '>' 100 ug.mL-1
Q64133 BXGT016109 Amine oxidase [flavin-containing] A reviewed - Maoa Ki '=' 19000 nM
P28593 BXGT009278 Trypanothione reductase reviewed - TPR Inhibition '=' 11 %
Q962Y6 BXGT019597 Thioredoxin glutathione reductase unreviewed - TGR Potency '=' 39810 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 19952 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 8492 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 10318 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Potency - 44668 nM
P0A0J7 BXGT006970 Quinolone resistance protein NorA reviewed - norA MEC '=' 50 ug ml-1
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 Emax '=' 91 %
P0A0J7 BXGT006970 Quinolone resistance protein NorA reviewed - norA MEC '=' 25 ug ml-1
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 11577 nM
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB IC50 '=' 483 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 0 %
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 186 %
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 16 %
P51151 BXGT010837 Ras-related protein Rab-9A reviewed - RAB9A Potency '=' 2511 nM
Q96RI1 BXGT019727 Bile acid receptor reviewed Nuclear receptor NR1H4 Potency - 44668 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 5623 nM
P0A0J7 BXGT006970 Quinolone resistance protein NorA reviewed - norA MIC '=' 4 ug.mL-1
P17405 BXGT008304 Sphingomyelin phosphodiesterase reviewed Enzyme SMPD1 Potency - 31622 nM
P02769 BXGT005956 Serum albumin reviewed - ALB Activity '=' 50 %
P18507 BXGT008411 Gamma-aminobutyric acid receptor subunit gamma-2 reviewed Ion channel GABRG2 EC50 '=' 52400 nM
P47870 BXGT010591 Gamma-aminobutyric acid receptor subunit beta-2 reviewed Ion channel GABRB2 EC50 '=' 52400 nM
P14867 BXGT008061 Gamma-aminobutyric acid receptor subunit alpha-1 reviewed Ion channel GABRA1 EC50 '=' 52400 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29092 nM
P19793 BXGT008515 Retinoic acid receptor RXR-alpha reviewed Nuclear receptor RXRA Potency - 35481 nM
A0A0C5K5S3 BXGT000138 Fluoroquinolone resistance protein unreviewed - mdeA MIC '=' 256 ug.mL-1
A0A0C5K5S3 BXGT000138 Fluoroquinolone resistance protein unreviewed - mdeA FC '=' 0 -
P04798 BXGT006265 Cytochrome P450 1A1 reviewed Enzyme CYP1A1 Inhibition '=' 42 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00013 Dill Anethum graveolens Herbs and Spices
BXGF00139 Pepper (Spice) Piper nigrum Herbs and Spices
BXGF00818 Herbs and Spices Herbs and Spices
BXGF00943 Brickellia longifolia Brickellia longifolia Others
BXGF00976 Verbesina virginica Verbesina virginica Others
BXGF01072 Dichotomanthes tristaniicarpa Dichotomanthes tristaniicarpa Others
BXGF01165 Cochlearia officinalis Cochlearia officinalis Medicinal Plant
BXGF01368 Frullania brasiliensis Frullania brasiliensis Medicinal Plant
BXGF01396 Bupleurum rigidum Bupleurum rigidum Medicinal Plant
BXGF01531 Abies webbiana Abies webbiana Medicinal Plant
BXGF03575 Palisota barteri Palisota barteri Others
BXGF03737 Matsumurella chinensis Matsumurella chinensis Others
BXGF04193 Piper longum Piper longum Medicinal Plant
BXGF04258 Rubia cordifolia Rubia cordifolia Medicinal Plant
BXGF04326 Piper betle Piper betle Medicinal Plant
BXGF04427 Silene banksia Silene banksia Others
BXGF04642 Podocarpus minor Podocarpus minor Others
BXGF04766 Artemisia coerulescens Artemisia coerulescens Others
BXGF05189 Dracontium loretense Dracontium loretense Others
BXGF05648 Euphorbia wangii Euphorbia wangii Others
BXGF05671 Carpesium longifolium Carpesium longifolium Medicinal Plant
BXGF05694 Piper retrofractum Piper retrofractum Medicinal Plant
BXGF05741 Crocus corsicus Crocus corsicus Others
BXGF05792 Schefflera venulosa Schefflera venulosa Medicinal Plant
BXGF06264 Homalium laurifolium Homalium laurifolium Others
BXGF06316 Coelogyne nitida Coelogyne nitida Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease