Showing entry for Gamma-aminobutyric acid receptor subunit gamma-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008411
Protein NameGamma-aminobutyric acid receptor subunit gamma-2
Uniport IdP18507
GeneGABRG2
Gene Id2566
DomainNeur_chan_LBD; Neur_chan_memb
Pfam PF02931   PF02932  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.6 Nervous system hsa04723 Retrograde endocannabinoid signaling
5. Organismal Systems 5.6 Nervous system hsa04727 GABAergic synapse
6. Human Diseases 6.5 Substance dependence hsa05032 Morphine addiction
6. Human Diseases 6.5 Substance dependence hsa05033 Nicotine addiction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030534 adult behavior
Biological Process GO:0071420 cellular response to histamine
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:1902476 chloride transmembrane transport
Biological Process GO:0007214 gamma-aminobutyric acid signaling pathway
Biological Process GO:1904862 inhibitory synapse assembly
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0050877 nervous system process
Biological Process GO:0009791 post-embryonic development
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0060078 regulation of postsynaptic membrane potential
Biological Process GO:0007165 signal transduction
Biological Process GO:0051932 synaptic transmission, GABAergic
molecular function GO:0008503 benzodiazepine receptor activity
molecular function GO:0005254 chloride channel activity
molecular function GO:0004890 GABA-A receptor activity
molecular function GO:0022851 GABA-gated chloride ion channel activity
molecular function GO:0005237 inhibitory extracellular ligand-gated ion channel activity
molecular function GO:0030594 neurotransmitter receptor activity
molecular function GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
cellular component GO:0030424 axon
cellular component GO:0034707 chloride channel complex
cellular component GO:0030659 cytoplasmic vesicle membrane
cellular component GO:0032590 dendrite membrane
cellular component GO:1902711 GABA-A receptor complex
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
cellular component GO:0098794 postsynapse
cellular component GO:0045211 postsynaptic membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-112316 Neuronal System
R-HSA-1236394 Signaling by ERBB4
R-HSA-162582 Signal Transduction
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-977443 GABA receptor activation
R-HSA-977443 GABA receptor activation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001956 BXGD000092 Alcohol Use Disorder Chemically-Induced Disorders; Mental Disorders
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006009 BXGD000359 Borderline intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0009171 BXGD000587 Cocaine Abuse Chemically-Induced Disorders; Mental Disorders
C0009952 BXGD000639 Febrile Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013132 BXGD000799 Drooling Stomatognathic Diseases
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014548 BXGD000928 Epilepsy, Generalized Nervous System Diseases
C0014553 BXGD000931 Absence Epilepsy Nervous System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0016202 BXGD001050 Flatfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0019147 BXGD001289 Hepatic Coma Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0019151 BXGD001290 Hepatic Encephalopathy Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0019569 BXGD001337 Hirschsprung Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0020578 BXGD001434 Hyperventilation Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0020608 BXGD001443 Hypodontia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0021125 BXGD001483 Impulsive Behavior Behavior and Behavior Mechanisms
C0023066 BXGD001605 Laryngospasm Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0023891 BXGD001714 Liver Cirrhosis, Alcoholic Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Chemically-Induced Disorders
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0028768 BXGD002084 Obsessive-Compulsive Disorder Mental Disorders
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0030232 BXGD002197 Pallor Pathological Conditions, Signs and Symptoms
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0035304 BXGD002528 Retinal Degeneration Eye Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037315 BXGD002687 Sleep Apnea Syndromes Respiratory Tract Diseases; Nervous System Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038580 BXGD002771 Substance Dependence Chemically-Induced Disorders; Mental Disorders
C0038868 BXGD002781 Progressive supranuclear palsy Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042024 BXGD002949 Urinary Incontinence Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0085633 BXGD003216 Mood swings Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0085762 BXGD003251 Alcohol abuse Chemically-Induced Disorders; Mental Disorders
C0149886 BXGD003379 Seizure, Febrile, Simple Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0149958 BXGD003395 Complex partial seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151611 BXGD003447 Electroencephalogram abnormal Nervous System Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0231686 BXGD004508 Gait, Unsteady Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0232466 BXGD004543 Feeding difficulties
C0233565 BXGD004590 Bradykinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234533 BXGD004687 Generalized seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0235659 BXGD004763 Reduced fetal movement Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0236733 BXGD004822 Amphetamine-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0236736 BXGD004825 Cocaine-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0236804 BXGD004835 Amphetamine Addiction Chemically-Induced Disorders; Mental Disorders
C0236807 BXGD004836 Amphetamine Abuse Chemically-Induced Disorders; Mental Disorders
C0239676 BXGD004989 High forehead
C0239981 BXGD005011 Hypoalbuminemia Hemic and Lymphatic Diseases
C0270834 BXGD006114 Complex partial seizure with impairment of consciousness Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270846 BXGD006116 Epileptic drop attack Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270850 BXGD006117 Idiopathic generalized epilepsy Nervous System Diseases
C0270853 BXGD006119 Juvenile Myoclonic Epilepsy Nervous System Diseases
C0311394 BXGD006884 Difficulty walking Pathological Conditions, Signs and Symptoms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0349506 BXGD007912 Photosensitivity of skin Skin and Connective Tissue Diseases
C0349588 BXGD007933 Short stature
C0376532 BXGD008000 Epilepsy, Rolandic Nervous System Diseases
C0391958 BXGD008020 Familial Epilepsies Nervous System Diseases
C0392699 BXGD008064 Dysesthesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0393593 BXGD008103 Dystonia Disorders Nervous System Diseases
C0423110 BXGD008471 Downward slant of palpebral fissure
C0424230 BXGD008522 Motor retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0426900 BXGD008596 Tibial torsion
C0431380 BXGD008680 Cortical Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0438696 BXGD008805 Suicidal Behavior and Behavior Mechanisms
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0476254 BXGD008984 Dyslexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0520966 BXGD009128 Abnormal coordination Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0543888 BXGD009300 Epileptic encephalopathy Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0595948 BXGD009630 Atypical absence seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0600427 BXGD009706 Cocaine Dependence Chemically-Induced Disorders; Mental Disorders
C0679136 BXGD009759 Low self-esteem Behavior and Behavior Mechanisms
C0684276 BXGD009793 Hypsarrhythmia Nervous System Diseases
C0748607 BXGD010201 Recurrent seizure Nervous System Diseases
C0751057 BXGD010307 Seizure, Febrile, Complex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751122 BXGD010325 Infantile Severe Myoclonic Epilepsy Nervous System Diseases
C0751197 BXGD010345 Fulminant Hepatic Failure with Cerebral Edema Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0751198 BXGD010346 Hepatic Stupor Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0752323 BXGD010716 Focal Clonic Seizures Nervous System Diseases
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C0863183 BXGD011274 Larynx carcinoma recurrent
C0877017 BXGD011329 Generalized tonic-clonic seizures with focal onset Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0949664 BXGD011583 Tauopathies Nervous System Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1611743 BXGD013456 Familial (FPAH)
C1719788 BXGD013661 Episodic ataxia type 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1834433 BXGD013973 Obsessive-compulsive trait Behavior and Behavior Mechanisms
C1836038 BXGD014073 Poor head control Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836830 BXGD014165 Developmental regression Mental Disorders
C1837352 BXGD014223 Childhood onset
C1837397 BXGD014227 Severe global developmental delay
C1838391 BXGD014313 Limb hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1838604 BXGD014325 EPILEPSY, CHILDHOOD ABSENCE, 1
C1839333 BXGD014369 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 2 Nervous System Diseases
C1842581 BXGD014525 Abnormal corpus callosum morphology Pathological Conditions, Signs and Symptoms
C1843244 BXGD014566 EPILEPSY, CHILDHOOD ABSENCE, SUSCEPTIBILITY TO, 2
C1844690 BXGD014662 Limited knee extension
C1854686 BXGD015423 Uncontrolled eye movements
C1854882 BXGD015439 Absent speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1855568 BXGD015511 Jerky head movements
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1857704 BXGD015741 Abnormal myelination
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1858674 BXGD015817 GENERALIZED EPILEPSY WITH FEBRILE SEIZURES PLUS, TYPE 3 Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1865313 BXGD016311 Speech articulation difficulties
C1867864 BXGD016472 Poor fine motor coordination
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C1963933 BXGD016705 Punding Mental Disorders
C2363129 BXGD017095 Benign Rolandic Epilepsy Nervous System Diseases
C2919142 BXGD017867 Short Stature, CTCAE
C3502809 BXGD019049 Generalized Epilepsy with Febrile Seizures Plus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3699402 BXGD019374 Alcohol abuse or dependence
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021087 BXGD020546 Abnormal social behavior Behavior and Behavior Mechanisms
C4021757 BXGD020760 EEG with polyspike wave complexes
C4021759 BXGD020762 Generalized myoclonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4022738 BXGD020974 Neurodevelopmental delay
C4022848 BXGD021011 EEG with centrotemporal focal spike waves
C4023511 BXGD021206 Obtundation status Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4023683 BXGD021240 EEG with spike-wave complexes
C4023684 BXGD021241 EEG with spike-wave complexes (>3.5 Hz)
C4023685 BXGD021242 EEG with spike-wave complexes (2.5-3.5 Hz)
C4023687 BXGD021243 EEG with multifocal slow activity
C4023701 BXGD021248 Impaired visuospatial constructive cognition
C4024906 BXGD021465 Hemifacial seizures Nervous System Diseases
C4024945 BXGD021492 Generalized cerebral atrophy/hypoplasia
C4025790 BXGD021791 Specific learning disability
C4025792 BXGD021792 EEG with irregular generalized spike and wave complexes
C4025846 BXGD021826 Abnormality of vision
C4049830 BXGD021953 Focal seizures, afebril Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4085238 BXGD022111 MYOCLONIC-ATONIC EPILEPSY
C4281785 BXGD022415 Childhood Absence Epilepsy Nervous System Diseases
C4316903 BXGD022711 Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4477055 BXGD022912 Limb myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4505072 BXGD022953 Epileptic Syndromes Nervous System Diseases
C4518639 BXGD023031 Epilepsy of infancy with migrating focal seizures Nervous System Diseases
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4552130 BXGD023490 Typical absence seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4553743 BXGD023548 Spasticity, CTCAE
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000203 Piperine 285.34
BXGC0000536 Phenol 94.11
BXGC0000964 6-Methylscutellarein 300.26
BXGC0001778 Scutellarein 286.24
BXGC0001841 Batatasin III 244.29
BXGC0002064 Amentoflavone 538.46
BXGC0002071 Apigenin 270.24
BXGC0002374 Taurine 125.15
BXGC0002867 Lappaurin 284.74
BXGC0003776 Flavones 222.24
BXGC0003885 Lormetazepam 335.19
BXGC0003886 N-Demethyldiazepam 270.71
BXGC0003963 Dechlorodiazepam 250.3
BXGC0004115 Norharman 168.19
BXGC0004596 2,6-Dibromophenol 251.9
BXGC0004662 2,6-Dimethylphenol 122.16
BXGC0004665 4-Aminobutyric acid 103.12
BXGC0005793 Baicalein 270.24
BXGC0005867 Serotonin 176.22
BXGC0006108 1H-Imidazole-4(5)-acetic acid 126.11
BXGC0007014 Harman 182.22
BXGC0008167 Chrysin 254.24
BXGC0016692 Wogonin 284.07
BXGC0021600 Ilepcimide 259.12
BXGC0021836 Honokiol 266.13
BXGC0030085 Bicuculline 367.11
BXGC0031558 Baicalin 446.08
BXGC0033643 2,4-di-tert-butylphenol 206.17
BXGC0038768 2,6-Ditert-Butylphenol 206.17
BXGC0041351 pyrogallol 1,3-dimethyl ether 154.06
BXGC0042358 1,3-DIISOPROPYLBENZENE 162.14
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein