Showing entry for Tricetin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0000461
Compound NameTricetin
Structure
FormulaC15H10O7
InchiKeyARSRJFRKVXALTF-UHFFFAOYSA-N
SMILESOC1=CC2=C(C(O)=C1)C(=O)C=C(O2)C1=CC(O)=C(O)C(O)=C1
InchiInChI=1S/C15H10O7/c16-7-3-8(17)14-9(18)5-12(22-13(14)4-7)6-1-10(19)15(21)11(20)2-6/h1-5,16-17,19-21H
IUPAC5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one
Molecular Weight302.24
Pubchem Id5281701
Chembl IdCHEMBL247484
Targets of Information Source
DrugBank DB08230
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P11309 BXGT007685 Serine/threonine-protein kinase pim-1 reviewed Kinase PIM1 experimental -
PDB MYF
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P11309 BXGT007685 Serine/threonine-protein kinase pim-1 reviewed PIM1 Kinase - - - -
Binding DB 26656
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT007685 Serine/threonine-protein kinase pim-1 reviewed Kinase PIM1 - 650 - -
reviewed BXGT007685 Serine/threonine-protein kinase pim-1 reviewed Kinase PIM1 - 646 - -
reviewed BXGT022265 Sialidase-2 reviewed Enzyme NEU2 - 130000 - -
CHEMBL CHEMBL247484
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 2511 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 25118 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 25118 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 35481 nM
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 25118 nM
P68871 BXGT011615 Hemoglobin subunit beta reviewed - HBB Potency '=' 25118 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 22387 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 22387 nM
Q9Y3R4 BXGT022265 Sialidase-2 reviewed Enzyme NEU2 IC50 '=' 130000 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Potency - 12589 nM
Q13332 BXGT013342 Receptor-type tyrosine-protein phosphatase S reviewed Enzyme PTPRS IC50 '=' 17500 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 39810 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 10000 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 17782 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 12589 nM
P04839 BXGT006273 Cytochrome b-245 heavy chain reviewed Ion channel CYBB Inhibition - - -
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 39810 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29092 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 28183 nM
P02791 BXGT005965 Ferritin light chain reviewed - FTL Potency '=' 39810 nM
P11309 BXGT007685 Serine/threonine-protein kinase pim-1 reviewed Kinase PIM1 #NAME? '=' 0 uM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 23109 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 19952 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 127 %
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 7943 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 707 nM
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 19952 nM
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 15848 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 15848 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 398 nM
P51570 BXGT010858 Galactokinase reviewed Kinase GALK1 Potency '=' 42128 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 79 %
Q13332 BXGT013342 Receptor-type tyrosine-protein phosphatase S reviewed Enzyme PTPRS Inhibition '=' 83 %
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 891 nM
Q15118 BXGT013540 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial reviewed Kinase PDK1 Inhibition '=' 27 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00038 Tea Camellia sinensis Teas
BXGF00151 Pomegranate Punica granatum Fruits
BXGF00337 Ginkgo nuts Ginkgo biloba Herbs and Spices
BXGF00810 Cereals and cereal products Cereals and cereal products
BXGF00819 Pulses Pulses
BXGF01304 Conyza canadensis Conyza canadensis Medicinal Plant
BXGF01362 Coreopsis fasciculata Coreopsis fasciculata Others
BXGF01498 Biebersteinia orphanidis Biebersteinia orphanidis Others
BXGF01601 Selinum carvifolium Selinum carvifolium Others
BXGF02254 Thuja plicata Thuja plicata Medicinal Plant
BXGF02970 Crepis foetida Crepis foetida Medicinal Plant
BXGF03014 Cirsium japonicum Cirsium japonicum Medicinal Plant
BXGF03039 Dorstenia lindeniana Dorstenia lindeniana Others
BXGF03059 Dioscoreophyllum cumminsii Dioscoreophyllum cumminsii Medicinal Plant
BXGF03121 Phytolacca acinosa Phytolacca acinosa Medicinal Plant
BXGF03140 Garcinia hombroniana Garcinia hombroniana Medicinal Plant
BXGF03192 Cardiospermum halicacabum Cardiospermum halicacabum Medicinal Plant
BXGF03213 Aglaia elaeagnoidea Aglaia elaeagnoidea Human Edible Plant
BXGF03272 Urtica triangularis Urtica triangularis Human Edible Plant
BXGF03320 Pouzolzia occidentalis Pouzolzia occidentalis Others
BXGF03344 Centaurea nigrescens Centaurea nigrescens Human Edible Plant
BXGF03400 Piper arboreum Piper arboreum Medicinal Plant
BXGF03431 Parastrephia lepidophylla Parastrephia lepidophylla Others
BXGF03445 Phlogacanthus thyrsiflorus Phlogacanthus thyrsiflorus Medicinal Plant
BXGF03455 Euphorbia segetalis Euphorbia segetalis Others
BXGF03465 Sidastrum acuminatum Sidastrum acuminatum Others
BXGF03480 Syncolostemon parviflorus Syncolostemon parviflorus Others
BXGF03491 Aristolochia elegans Aristolochia elegans Others
BXGF03503 Penstemon secundiflorus Penstemon secundiflorus Others
BXGF03541 Cuphea carthagenensis Cuphea carthagenensis Others
BXGF03552 Ozoroa insignis Ozoroa insignis Medicinal Plant
BXGF03571 Ruta microcarpa Ruta microcarpa Medicinal Plant
BXGF03579 Crinum defixum Crinum defixum Medicinal Plant
BXGF03742 Zanthoxylum monophyllum Zanthoxylum monophyllum Others
BXGF04756 Astragalus gummifer Astragalus gummifer Medicinal Plant
BXGF04890 Triglochin maritima Triglochin maritima Medicinal Plant
BXGF05640 Phedimus kamtschaticus Phedimus kamtschaticus Medicinal Plant
BXGF06296 Eucalyptus maideni Eucalyptus maideni Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease