Showing entry for Galactokinase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010858
Protein NameGalactokinase
Uniport IdP51570
GeneGALK1
Gene Id2584
DomainGalKase_gal_bdg; GHMP_kinases_C; GHMP_kinases_N
Pfam PF10509   PF08544   PF00288  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00052 Galactose metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00520 Amino sugar and nucleotide sugar metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019402 galactitol metabolic process
Biological Process GO:0019388 galactose catabolic process
Biological Process GO:0006012 galactose metabolic process
Biological Process GO:0061623 glycolytic process from galactose
molecular function GO:0005524 ATP binding
molecular function GO:0004335 galactokinase activity
molecular function GO:0005534 galactose binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0016020 membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1643685 Disease
R-HSA-3781865 Diseases of glycosylation
R-HSA-5609975 Diseases associated with glycosylation precursor biosynthesis
R-HSA-5609976 Defective GALK1 can cause Galactosemia II (GALCT2)
R-HSA-5668914 Diseases of metabolism
R-HSA-70370 Galactose catabolism
R-HSA-71387 Metabolism of carbohydrates
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009691 BXGD000622 Congenital cataract Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Nervous System Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0016952 BXGD001085 Galactosemias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0025521 BXGD001876 Inborn Errors of Metabolism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027960 BXGD002062 Nevus Neoplasms
C0027962 BXGD002064 Melanocytic nevus Neoplasms
C0036646 BXGD002627 Age-related cataract Eye Diseases
C0080333 BXGD003114 Weber-Cockayne Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0152259 BXGD003576 Cataract secondary to ocular disorder Eye Diseases
C0154971 BXGD003761 Presenile cataract Eye Diseases
C0268151 BXGD005838 Classical galactosemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0268155 BXGD005840 Deficiency of galactokinase Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0268157 BXGD005841 Galactosuria
C0268374 BXGD005918 Adult junctional epidermolysis bullosa (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0342745 BXGD007539 Disorder of galactose metabolism
C0521707 BXGD009166 Bilateral cataracts (disorder) Eye Diseases
C0524524 BXGD009228 Pseudoaphakia Eye Diseases
C0751161 BXGD010334 UDPglucose 4-epimerase deficiency disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1306068 BXGD012354 After-cataract Eye Diseases
C1456781 BXGD013123 Benign melanocytic nevus Neoplasms
C1510497 BXGD013174 Lens Opacities Eye Diseases
C1856934 BXGD015659 Epidermolysis bullosa with pyloric atresia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1859236 BXGD015867 Prolonged neonatal jaundice Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3277059 BXGD018699 Congenital Bilateral Cataracts
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4021643 BXGD020716 Impairment of galactose metabolism
C4023071 BXGD021096 Hypergalactosemia
C4721766 BXGD023764 Unspecified secondary cataract Eye Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000323 Isotheaflavin 564.49
BXGC0000430 Gossypol 518.55
BXGC0000461 Tricetin 302.24
BXGC0001746 Theaflavin 3,3'-digallate 868.7
BXGC0002588 Magnesium 24.31
BXGC0003852 Nigrin B 506.47
BXGC0004322 xi-3-Hydroxy-5-phenylpentanoic acid O-beta-D-Glucopyranoside 356.37
BXGC0005683 Quercetin 302.24
BXGC0006635 Luteolin 286.24
BXGC0027956 SHU 508 180.06
BXGC0028001 Beta-Lapachone 242.09
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
BXGC0052355 [5,7-Dihydroxy-2-(3,4,5-Trihydroxyphenyl)-3,4-Dihydro-2H-Chromen-3-Yl] 3,4,5-Trihydroxybenzoate 458.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein