Showing entry for L-Malic acid


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0000647
Compound NameL-Malic acid
Structure
FormulaC4H6O5
InchiKeyBJEPYKJPYRNKOW-REOHCLBHSA-N
SMILESO[C@@H](CC(O)=O)C(O)=O
InchiInChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/t2-/m0/s1
IUPAC(2S)-2-hydroxybutanedioic acid
Molecular Weight134.09
Pubchem Id222656
Chembl Id
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB LMR
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P23007 BXGT008826 Citrate synthase, mitochondrial reviewed CS - - - - -
P23368 BXGT008856 NAD-dependent malic enzyme, mitochondrial reviewed ME2 Enzyme - - - -
Q8N8N7 BXGT018529 Prostaglandin reductase 2 reviewed PTGR2 Enzyme - - - -
Q7DDU0 BXGT016970 Polysialic acid capsule biosynthesis protein SiaC unreviewed siaC - - - - -
Q88E10 BXGT017707 Methyl-accepting chemotaxis protein McpS reviewed mcpS - - - - -
Q8EMJ9 BXGT018116 Galactarate dehydratase (D-threo-forming) reviewed OB2843 - - - - -
Q93NW7 BXGT019515 AmphB unreviewed amphB - - - - -
P9WJB7 BXGT012337 Nucleoid-associated protein EspR reviewed espR - - - - -
C8WUX4 BXGT002640 Histidine--tRNA ligase unreviewed Aaci_0923 - - - - -
A1VZ59 BXGT001057 Glycine--tRNA ligase alpha subunit reviewed glyQ - - - - -
Q9PPK3 BXGT021347 Glycine--tRNA ligase alpha subunit reviewed glyQ - - - - -
B1MKP6 BXGT001907 Fumarate hydratase class II unreviewed fumC - - - - -
A0A0H3M4F9 BXGT000485 Inorganic pyrophosphatase unreviewed ppa - - - - -
B1MGB2 BXGT001898 Methionine aminopeptidase unreviewed map - - - - -
P9WN93 BXGT012406 Fumarate hydratase class II reviewed fumC - - - - -
P23946 BXGT008932 Chymase reviewed CMA1 Enzyme - - - -
Q96AX1 BXGT019620 Vacuolar protein sorting-associated protein 33A reviewed VPS33A Transporter - - - -
P0DPI1 BXGT007529 Botulinum neurotoxin type A reviewed botA - - - - -
P35747 BXGT009862 Serum albumin reviewed ALB - - - - -
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed PIN1 - - - - -
Q57265 BXGT015115 Capsule biosynthesis protein unreviewed synC - - - - -
B9JNP7 BXGT002331 Isomerase protein unreviewed Arad_7740 - - - - -
P14639 BXGT008032 Serum albumin reviewed ALB - - - - -
Q9HVH5 BXGT020619 Probable c4-dicarboxylate-binding protein unreviewed PA4616 - - - - -
A3QCW5 BXGT001185 Solute-binding protein Shew_1446 reviewed dctP - - - - -
P40926 BXGT010207 Malate dehydrogenase, mitochondrial reviewed MDH2 Enzyme - - - -
Q12797 BXGT013266 Aspartyl/asparaginyl beta-hydroxylase reviewed ASPH - - - - -
H2FH31 BXGT003585 GalNAc/Gal-specific lectin unreviewed - - - - -
O14607 BXGT004075 Histone demethylase UTY reviewed UTY Transcription factor - - - -
Q9UGL1 BXGT021685 Lysine-specific demethylase 5B reviewed KDM5B Epigenetic regulator - - - -
Q9UJV9 BXGT021731 Probable ATP-dependent RNA helicase DDX41 reviewed DDX41 - - - - -
P9WK17 BXGT012353 Malate synthase G reviewed glcB - - - - -
O57767 BXGT004761 Quinolinate synthase A reviewed nadA - - - - -
E9AE57 BXGT003165 Fumarate hydratase 2 reviewed FH2 - - 9800000 - -
Q58261 BXGT015182 Tetrahydromethanopterin S-methyltransferase subunit A reviewed mtrA - - - - -
P44427 BXGT010427 Malate dehydrogenase reviewed mdh - - - - -
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed IDH1 - - - - -
Q9AGA6 BXGT020060 6-phospho-alpha-glucosidase reviewed aglB - - - - -
P49773 BXGT010741 Histidine triad nucleotide-binding protein 1 reviewed HINT1 Enzyme - - - -
P0ADP7 BXGT024147 Ubiquinone biosynthesis protein UbiJ reviewed ubiJ - - - - -
Q6N446 BXGT016390 Possible TctC subunit of the Tripartite Tricarboxylate Transport(TTT) Family unreviewed RPA3494 - - - - -
Q6N446 BXGT016390 Possible TctC subunit of the Tripartite Tricarboxylate Transport(TTT) Family unreviewed RPA3494 - - - 27 -
Q8NN33 BXGT024371 Malate dehydrogenase reviewed mdh - - - - -
A0A2H4T920 BXGT024754 Taurine catabolism dioxygenase unreviewed - - - - -
B5ZA44 BXGT025200 Guanosine pentaphosphate phosphohydrolase unreviewed HPG27_257 - - - - -
Q9AJC4 BXGT024246 ATP-citrate lyase alpha-subunit unreviewed aclA - - - - -
E9AE57 BXGT003165 Fumarate hydratase 2 reviewed FH2 - - - - -
A0A023UGN9 BXGT000010 Beta-galactosidase unreviewed - - - - -
Binding DB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
CHEMBL n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00012 Pineapple Ananas comosus Fruits
BXGF00040 Pepper (C. annuum) Capsicum annuum Vegetables
BXGF00049 Chicory Cichorium intybus Vegetables
BXGF00087 Sea-buckthornberry Hippophae rhamnoides Fruits
BXGF00105 Apple Malus pumila Fruits
BXGF00149 Peach Prunus persica Fruits
BXGF00150 Guava Psidium guajava Fruits
BXGF00151 Pomegranate Punica granatum Fruits
BXGF00181 Dandelion Taraxacum officinale Herbs and Spices
BXGF00808 Pomes Fruits
BXGF00823 Fruits Fruits
BXGF00956 Passiflora incarnata Passiflora incarnata Medicinal Plant
BXGF00981 Flacourtia jangomas Flacourtia jangomas Medicinal Plant
BXGF01126 Polygonum cuspidatum Polygonum cuspidatum Medicinal Plant
BXGF01140 Angelica gigas Angelica gigas Medicinal Plant
BXGF01147 Chelidonium majus Chelidonium majus Medicinal Plant
BXGF01157 Alstonia muelleriana Alstonia muelleriana Others
BXGF01185 Aloe vera Aloe vera Medicinal Plant
BXGF01187 Onobrychis arenaria Onobrychis arenaria Others
BXGF01205 Dacrydium cupressinum Dacrydium cupressinum Medicinal Plant
BXGF01223 Eria mollis Eria mollis Others
BXGF01302 Dysoxylum cumingianum Dysoxylum cumingianum Others
BXGF01344 Psychotria stachyoides Psychotria stachyoides Others
BXGF01391 Dodonaea viscosa Dodonaea viscosa Medicinal Plant
BXGF01426 Cornus officinalis Cornus officinalis Medicinal Plant
BXGF01448 Trigonella grandiflora Trigonella grandiflora Others
BXGF01554 Nicotiana undulata Nicotiana undulata Others
BXGF01568 Teucrium yemense Teucrium yemense Others
BXGF01641 Neobalanocarpus heimii Neobalanocarpus heimii Others
BXGF01668 Taraxacum platycarpum Taraxacum platycarpum Medicinal Plant
BXGF01683 Aconitum tasiromontanum Aconitum tasiromontanum Others
BXGF01764 Dendriopoterium menendezii Dendriopoterium menendezii Others
BXGF01794 Adansonia grandidieri Adansonia grandidieri Human Edible Plant
BXGF01812 Physalis alkekengi Physalis alkekengi Medicinal Plant
BXGF01821 Artemisia cina Artemisia cina Medicinal Plant
BXGF01836 Aphyllocladus denticulatus Aphyllocladus denticulatus Others
BXGF01850 Bassia muricata Bassia muricata Medicinal Plant
BXGF01900 Aloe ferox Aloe ferox Medicinal Plant
BXGF01911 Bupleurum scorzonerifolium Bupleurum scorzonerifolium Medicinal Plant
BXGF01947 Senecio subdentatus Senecio subdentatus Others
BXGF02006 Aconitum seravschanicum Aconitum seravschanicum Others
BXGF02049 Angelica sinensis Angelica sinensis Medicinal Plant
BXGF02152 Taraxacum borealisinense Taraxacum borealisinense Others
BXGF02377 Cichorium glandulosum Cichorium glandulosum Others
BXGF02757 Tripolium pannonicum Tripolium pannonicum Others
BXGF02787 Melia azedarach Melia azedarach Medicinal Plant
BXGF02925 Coreopsis nodosa Coreopsis nodosa Others
BXGF03180 Uvaria calamistrata Uvaria calamistrata Medicinal Plant
BXGF03199 Combretum indicum Combretum indicum Medicinal Plant
BXGF03485 Justicia secunda Justicia secunda Others
BXGF03488 Paeonia suffruticosa Paeonia suffruticosa Medicinal Plant
BXGF03508 Haematococcus lacustris Haematococcus lacustris Others
BXGF03630 Taraxacum coreanum Taraxacum coreanum Others
BXGF04205 Aster sedifolius Aster sedifolius Others
BXGF04209 Chaenomeles sinensis Chaenomeles sinensis Medicinal Plant
BXGF04310 Taraxacum mongolicum Taraxacum mongolicum Medicinal Plant
BXGF04573 Rubia akane Rubia akane Medicinal Plant
BXGF04631 Aloe spicata Aloe spicata Medicinal Plant
BXGF04659 Phyllanthus emblica Phyllanthus emblica Medicinal Plant
BXGF04712 Prunus mume Prunus mume Medicinal Plant
BXGF04842 Angelica acutiloba Angelica acutiloba Medicinal Plant
BXGF04875 Bupleurum chinense Bupleurum chinense Medicinal Plant
BXGF04905 Aloe Aloe Medicinal Plant
BXGF04909 Hippophae fructus Hippophae fructus Others
BXGF04926 Aloe africana Aloe africana Medicinal Plant
BXGF04981 Bupleurum falcatum Bupleurum falcatum Medicinal Plant
BXGF05018 Lavandula vera Lavandula vera Medicinal Plant
BXGF05140 Amomum neoaurantiacum Amomum neoaurantiacum Others
BXGF05210 Homalomena occulta Homalomena occulta Medicinal Plant
BXGF05297 Isatis tinctoria Isatis tinctoria Medicinal Plant
BXGF05413 Glycine tomentella Glycine tomentella Human Edible Plant
BXGF05421 Tussilago farfara Tussilago farfara Medicinal Plant
BXGF05571 Ziziphus jujuba Ziziphus jujuba Medicinal Plant
BXGF05817 Panax schinseng Panax schinseng Others
BXGF05819 Citrus aurantium Citrus aurantium Medicinal Plant
BXGF05834 Schisandra sphenanthera Schisandra sphenanthera Medicinal Plant
BXGF05944 Senecio paludaffinis Senecio paludaffinis Others
BXGF05962 Rehmannia glutinosa Rehmannia glutinosa Medicinal Plant
BXGF05977 Schisandra chinensis Schisandra chinensis Medicinal Plant
BXGF06011 Enceliopsis argophylla Enceliopsis argophylla Others
BXGF06143 Persicaria tinctoria Persicaria tinctoria Medicinal Plant
BXGF06281 Miliusa velutina Miliusa velutina Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease