Showing entry for Aspartyl/asparaginyl beta-hydroxylase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013266
Protein NameAspartyl/asparaginyl beta-hydroxylase
Uniport IdQ12797
GeneASPH
Gene Id444
DomainAsp-B-Hydro_N; Asp_Arg_Hydrox; TPR_16
Pfam PF05279   PF05118  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04260 Cardiac muscle contraction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0097202 activation of cysteine-type endopeptidase activity
Biological Process GO:0032237 activation of store-operated calcium channel activity
Biological Process GO:0055074 calcium ion homeostasis
Biological Process GO:0070588 calcium ion transmembrane transport
Biological Process GO:0071277 cellular response to calcium ion
Biological Process GO:0005513 detection of calcium ion
Biological Process GO:0060325 face morphogenesis
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0035108 limb morphogenesis
Biological Process GO:0006936 muscle contraction
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0007389 pattern specification process
Biological Process GO:0042264 peptidyl-aspartic acid hydroxylation
Biological Process GO:0010524 positive regulation of calcium ion transport into cytosol
Biological Process GO:0090316 positive regulation of intracellular protein transport
Biological Process GO:0045862 positive regulation of proteolysis
Biological Process GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:1903779 regulation of cardiac conduction
Biological Process GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
Biological Process GO:0010649 regulation of cell communication by electrical coupling
Biological Process GO:0031585 regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
Biological Process GO:1901879 regulation of protein depolymerization
Biological Process GO:0031647 regulation of protein stability
Biological Process GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Biological Process GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
Biological Process GO:0033198 response to ATP
Biological Process GO:0060021 roof of mouth development
molecular function GO:0005509 calcium ion binding
molecular function GO:0009055 electron transfer activity
molecular function GO:0044325 ion channel binding
molecular function GO:0004597 peptide-aspartate beta-dioxygenase activity
molecular function GO:0062101 peptidyl-aspartic acid 3-dioxygenase activity
molecular function GO:0008307 structural constituent of muscle
molecular function GO:0005198 structural molecule activity
cellular component GO:0034704 calcium channel complex
cellular component GO:0032541 cortical endoplasmic reticulum
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0030176 integral component of endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0014701 junctional sarcoplasmic reticulum membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0033018 sarcoplasmic reticulum lumen
cellular component GO:0033017 sarcoplasmic reticulum membrane
Reactome
Pathway Id Pathway Name
R-HSA-2672351 Stimuli-sensing channels
R-HSA-382551 Transport of small molecules
R-HSA-397014 Muscle contraction
R-HSA-5576891 Cardiac conduction
R-HSA-5578775 Ion homeostasis
R-HSA-983712 Ion channel transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000786 BXGD000010 Spontaneous abortion Female Urogenital Diseases and Pregnancy Complications
C0003130 BXGD000183 Anoxia Pathological Conditions, Signs and Symptoms
C0005396 BXGD000310 Bile Duct Neoplasms Digestive System Diseases; Neoplasms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007120 BXGD000435 Bronchioloalveolar Adenocarcinoma Neoplasms
C0013581 BXGD000855 Ectopia Lentis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0024636 BXGD001793 Malocclusion Stomatognathic Diseases
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0206093 BXGD004154 Neuroectodermal Tumors Neoplasms
C0206663 BXGD004225 Neuroectodermal Tumor, Primitive Neoplasms
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0240538 BXGD005041 Convex nasal ridge
C0241910 BXGD005123 Autoimmune Chronic Hepatitis Digestive System Diseases; Immune System Diseases
C0267818 BXGD005781 Bile duct proliferation Digestive System Diseases
C0278479 BXGD006509 Stage II Colon Cancer Digestive System Diseases; Neoplasms
C0278488 BXGD006515 Carcinoma breast stage IV
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0345905 BXGD007746 Intrahepatic Cholangiocarcinoma Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0423110 BXGD008471 Downward slant of palpebral fissure
C0423319 BXGD008479 Atrophic iris Eye Diseases
C0424503 BXGD008532 Dysmorphic facies
C0426415 BXGD008560 Large nose
C0521158 BXGD009130 Recurrent tumor
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0677898 BXGD009735 invasive cancer Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0687720 BXGD009844 Central Diabetes Insipidus Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740277 BXGD009972 Bile duct carcinoma Digestive System Diseases; Neoplasms
C0854196 BXGD011006 Hepatobiliary neoplasm Digestive System Diseases; Neoplasms
C1176475 BXGD011798 Ductal Carcinoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1281300 BXGD012130 Vascular degeneration Cardiovascular Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1334953 BXGD012746 Neuroblastic tumors Neoplasms
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1527349 BXGD013277 Ductal Breast Carcinoma Neoplasms
C1608408 BXGD013434 Malignant transformation
C1631597 BXGD013480 VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder) Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1821417 BXGD013764 RESTING HEART RATE
C1832167 BXGD013805 Ectopia Lentis, Spontaneous Filtering Blebs, and Craniofacial Dysmorphism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1868684 BXGD016527 EAR, PATELLA, SHORT STATURE SYNDROME Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C2985280 BXGD018223 Blood Protein Measurement
C3146257 BXGD018265 Stage II Colon Cancer AJCC v7
C3494422 BXGD018966 Retrognathia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C3642346 BXGD019245 Luminal B Breast Carcinoma
C4025579 BXGD021676 Large beaked nose
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4284013 BXGD022428 Primary cholangiocarcinoma of intrahepatic biliary tract Neoplasms
C4525119 BXGD023118 Stage II Colon Cancer AJCC v8
C4721555 BXGD023755 Autoimmune hepatitis Digestive System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000647 L-Malic acid 134.09
BXGC0006186 L-Aspartic acid 133.1
BXGC0006368 Formic acid 46.03
BXGC0030612 tetraethylene glycol 194.12
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein