Showing entry for Malate dehydrogenase, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010207
Protein NameMalate dehydrogenase, mitochondrial
Uniport IdP40926
GeneMDH2
Gene Id4191
DomainLdh_1_C; Ldh_1_N
Pfam PF02866   PF00056  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00020 Citrate cycle (TCA cycle)
1. Metabolism 1.5 Amino acid metabolism hsa00270 Cysteine and methionine metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00620 Pyruvate metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00630 Glyoxylate and dicarboxylate metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01200 Carbon metabolism
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0009060 aerobic respiration
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0006108 malate metabolic process
Biological Process GO:0006734 NADH metabolic process
Biological Process GO:0006107 oxaloacetate metabolic process
Biological Process GO:0006099 tricarboxylic acid cycle
molecular function GO:0030060 L-malate dehydrogenase activity
molecular function GO:0046554 malate dehydrogenase (NADP+) activity
molecular function GO:0043621 protein self-association
molecular function GO:0003723 RNA binding
cellular component GO:0005737 cytoplasm
cellular component GO:0070062 extracellular exosome
cellular component GO:0016020 membrane
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005739 mitochondrion
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport
R-HSA-1430728 Metabolism
R-HSA-70263 Gluconeogenesis
R-HSA-70326 Glucose metabolism
R-HSA-71387 Metabolism of carbohydrates
R-HSA-71403 Citric acid cycle (TCA cycle)
R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001627 BXGD000068 Congenital adrenal hyperplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003076 BXGD000171 Aniridia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0006309 BXGD000392 Brucellosis Infections
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007120 BXGD000435 Bronchioloalveolar Adenocarcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007786 BXGD000486 Brain Ischemia Nervous System Diseases; Cardiovascular Diseases
C0008031 BXGD000511 Chest Pain Pathological Conditions, Signs and Symptoms
C0009777 BXGD000630 Conn Adenoma Neoplasms; Endocrine System Diseases
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0016382 BXGD001054 Flushing Pathological Conditions, Signs and Symptoms
C0017152 BXGD001096 Gastritis Digestive System Diseases
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0018777 BXGD001217 Conductive hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018965 BXGD001258 Hematuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020437 BXGD001381 Hypercalcemia Nutritional and Metabolic Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0024667 BXGD001794 Animal Mammary Neoplasms Neoplasms; Animal Diseases
C0024668 BXGD001795 Mammary Neoplasms, Experimental Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026552 BXGD001906 Morphine Dependence Chemically-Induced Disorders; Mental Disorders
C0026936 BXGD001950 Mycoplasma Infections Infections
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027497 BXGD001993 Nausea Pathological Conditions, Signs and Symptoms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030232 BXGD002197 Pallor Pathological Conditions, Signs and Symptoms
C0030252 BXGD002199 Palpitations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0030421 BXGD002218 Paraganglioma Neoplasms
C0031511 BXGD002304 Pheochromocytoma Neoplasms
C0033687 BXGD002415 Proteinuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0039239 BXGD002803 Sinus Tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042928 BXGD003014 Vocal Cord Paralysis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0086769 BXGD003310 Panic Attacks Mental Disorders
C0152132 BXGD003547 Hypertensive Retinopathy Eye Diseases; Cardiovascular Diseases
C0153567 BXGD003665 Uterine Cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0178664 BXGD004032 Glomerulosclerosis (disorder) Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0205696 BXGD004107 Anaplastic carcinoma Neoplasms
C0205697 BXGD004108 Carcinoma, Spindle-Cell Neoplasms
C0205698 BXGD004109 Undifferentiated carcinoma Neoplasms
C0205699 BXGD004110 Carcinomatosis Neoplasms
C0206686 BXGD004241 Adrenocortical carcinoma Neoplasms; Endocrine System Diseases
C0232466 BXGD004543 Feeding difficulties
C0234251 BXGD004645 Inflammatory pain Pathological Conditions, Signs and Symptoms
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0521670 BXGD009160 Cranial nerve compression Nervous System Diseases; Wounds and Injuries
C0522357 BXGD009202 Vertigo, Paroxysmal Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0541794 BXGD009262 Skeletal muscle atrophy
C0543888 BXGD009300 Epileptic encephalopathy Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0563625 BXGD009484 Agnosia for Pain Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0730303 BXGD009950 Capillary hemangioma of retina Neoplasms; Cardiovascular Diseases
C0740279 BXGD009973 Cerebellar atrophy
C0751559 BXGD010500 Pulsatile Tinnitus Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1096063 BXGD011600 Drug Resistant Epilepsy Nervous System Diseases
C1150891 BXGD011767 peptidylamidoglycolate lyase activity
C1167918 BXGD011779 Increased CSF lactate
C1257877 BXGD011812 Pheochromocytoma, Extra-Adrenal Neoplasms
C1257925 BXGD011814 Mammary Carcinoma, Animal Neoplasms; Animal Diseases
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1269955 BXGD012005 Tumor Cell Invasion
C1277241 BXGD012110 Delayed myelination Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1333944 BXGD012657 Paraganglioma of head and neck Neoplasms
C1387805 BXGD012958 Episodic paroxysmal anxiety Behavior and Behavior Mechanisms
C1510472 BXGD013170 Drug Dependence Chemically-Induced Disorders; Mental Disorders
C1527344 BXGD013275 Dysphonia Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1708353 BXGD013599 Hereditary Paraganglioma-Pheochromocytoma Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C1836038 BXGD014073 Poor head control Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836440 BXGD014115 Increased serum lactate Nutritional and Metabolic Diseases
C1854882 BXGD015439 Absent speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1856408 BXGD015603 Infantile encephalopathy Nervous System Diseases
C1857171 BXGD015680 Episodic hyperhidrosis Skin and Connective Tissue Diseases
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1868393 BXGD016498 Elevated urinary epinephrine
C1868394 BXGD016499 Elevated calcitonin
C1963101 BXGD016683 Encephalopathy, CTCAE 3.0
C2315100 BXGD017021 Pediatric failure to thrive Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Mental Disorders
C2937358 BXGD018159 Cerebral Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C3160712 BXGD018467 Palpitations, CTCAE
C3808022 BXGD019536 Episodic abdominal pain Pathological Conditions, Signs and Symptoms
C4022998 BXGD021058 Arachnoid hemangiomatosis Neoplasms
C4023099 BXGD021105 Elevated urinary dopamine
C4025594 BXGD021683 Positive regitine blocking test
C4025626 BXGD021701 Elevated urinary norepinephrine
C4293708 BXGD022515 Recurrent paroxysmal headache Pathological Conditions, Signs and Symptoms
C4479208 BXGD022927 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 51
C4551628 BXGD023373 Opiate Abuse Chemically-Induced Disorders; Mental Disorders
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000279 L-Alanine 89.09
BXGC0000647 L-Malic acid 134.09
BXGC0003705 Chloride 35.45
BXGC0004187 D-Malic acid 134.09
BXGC0006198 Citric acid 192.12
BXGC0025862 Levothyroxine 776.69
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein