Showing entry for Histidine triad nucleotide-binding protein 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010741
Protein NameHistidine triad nucleotide-binding protein 1
Uniport IdP49773
GeneHINT1
Gene Id3094
DomainHIT
Pfam PF01230  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Biological Process GO:0050850 positive regulation of calcium-mediated signaling
Biological Process GO:0009154 purine ribonucleotide catabolic process
Biological Process GO:0006355 regulation of transcription, DNA-templated
Biological Process GO:0007165 signal transduction
molecular function GO:0016787 hydrolase activity
molecular function GO:0000166 nucleotide binding
molecular function GO:0005080 protein kinase C binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005856 cytoskeleton
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0000118 histone deacetylase complex
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007682 BXGD000471 CNS disorder Nervous System Diseases
C0007959 BXGD000507 Charcot-Marie-Tooth Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0012833 BXGD000795 Dizziness Pathological Conditions, Signs and Symptoms
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0015644 BXGD001008 Muscular fasciculation Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0016506 BXGD001062 Foot Deformities Musculoskeletal Diseases
C0018081 BXGD001171 Gonorrhea Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020458 BXGD001393 Hyperhidrosis disorder Skin and Connective Tissue Diseases
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026106 BXGD001889 Mild Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027125 BXGD001975 Myotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027888 BXGD002056 Hereditary Motor and Sensory Neuropathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030554 BXGD002239 Paresthesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0037763 BXGD002699 Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039273 BXGD002806 Talipes cavus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0149678 BXGD003346 Epstein-Barr Virus Infections Infections
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0221170 BXGD004400 Muscular stiffness Nervous System Diseases
C0221373 BXGD004454 Claw hand Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0235025 BXGD004713 Peripheral motor neuropathy Nervous System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0241005 BXGD005072 Creatine phosphokinase serum increased
C0242287 BXGD005145 Isaacs syndrome Musculoskeletal Diseases; Nervous System Diseases
C0270790 BXGD006105 Quadriparesis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270914 BXGD006131 Hereditary Motor and Sensory-Neuropathy Type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0270921 BXGD006133 Axonal neuropathy Nervous System Diseases
C0271683 BXGD006234 Polyneuropathy, Motor Nervous System Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0338831 BXGD007216 Manic Mental Disorders
C0339789 BXGD007282 Congenital deafness Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Nervous System Diseases; Otorhinolaryngologic Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0409348 BXGD008384 Flexion contracture of proximal interphalangeal joint
C0410264 BXGD008423 Contracture of tendo achilles
C0424551 BXGD008533 Impaired exercise tolerance
C0427149 BXGD008608 Gait, Drop Foot Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0497219 BXGD009056 Hearing complaints (excluding H84-86)
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0541794 BXGD009262 Skeletal muscle atrophy
C0558845 BXGD009459 Reflex, Ankle, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598589 BXGD009667 Inherited neuropathies Nervous System Diseases
C0684219 BXGD009789 Myokymia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0751919 BXGD010643 Acquired Neuromyotonia Musculoskeletal Diseases; Nervous System Diseases
C0850703 BXGD010905 Frequent falls Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1112256 BXGD011655 Sensorimotor neuropathy
C1263857 BXGD011900 Peripheral axonal neuropathy Nervous System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1389118 BXGD012966 Peroneal muscle atrophy
C1510472 BXGD013170 Drug Dependence Chemically-Induced Disorders; Mental Disorders
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1834536 BXGD013977 Weakness of the intrinsic hand muscles
C1836450 BXGD014117 Distal lower limb muscle weakness
C1836451 BXGD014118 Distal lower limb amyotrophy
C1836527 BXGD014127 Distal sensory impairment of all modalities
C1836843 BXGD014168 Progressive inability to walk
C1842587 BXGD014526 Sensory axonal neuropathy
C1847584 BXGD014876 Distal sensory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1849134 BXGD015010 Impaired vibration sensation in the lower limbs
C1854657 BXGD015418 Limb fasciculations Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1857790 BXGD015748 Thoracic scoliosis Musculoskeletal Diseases
C1861063 BXGD016011 TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)
C1864716 BXGD016245 Intrinsic hand muscle atrophy
C1866141 BXGD016379 Foot dorsiflexor weakness
C1868623 BXGD016517 Handgrip myotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2749625 BXGD017629 Motor axonal neuropathy
C2932678 BXGD018098 Inherited Peripheral Neuropathy Nervous System Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3850141 BXGD019810 Acute-On-Chronic Liver Failure Digestive System Diseases
C4021650 BXGD020720 Short third metatarsal
C4022166 BXGD020888 EMG: myokymic discharges Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4022585 BXGD020926 Fatigable weakness of distal limb muscles
C4024601 BXGD021334 Weakness of long finger extensor muscles
C4024607 BXGD021338 Exercise-induced leg cramps
C4025614 BXGD021695 EMG: chronic denervation signs
C4025790 BXGD021791 Specific learning disability
C4280804 BXGD022408 Percussion-induced rapid rolling muscle contractions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4316810 BXGD022702 Writer's Cramp Nervous System Diseases
C4521481 BXGD023060 Pseudomyotonia (finding) Musculoskeletal Diseases; Nervous System Diseases
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000647 L-Malic acid 134.09
BXGC0002374 Taurine 125.15
BXGC0002605 Adenosine 267.24
BXGC0003418 Undylic acid 324.18
BXGC0003705 Chloride 35.45
BXGC0024261 Adenosine Phosphate 347.06
BXGC0027925 Cpg 363.06
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein