Showing entry for Rhamnetin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0002094
Compound NameRhamnetin
Structure
FormulaC16H12O7
InchiKeyJGUZGNYPMHHYRK-UHFFFAOYSA-N
SMILESCOC1=CC(O)=C2C(=O)C(O)=C(OC2=C1)C1=CC(O)=C(O)C=C1
InchiInChI=1S/C16H12O7/c1-22-8-5-11(19)13-12(6-8)23-16(15(21)14(13)20)7-2-3-9(17)10(18)4-7/h2-6,17-19,21H,1H3
IUPAC2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H-chromen-4-one
Molecular Weight316.26
Pubchem Id5281691
Chembl IdCHEMBL312163
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB J8G
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Q8NFU5 BXGT018564 Inositol polyphosphate multikinase reviewed IPMK Kinase - 14000 - -
Binding DB 23410
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT006255 Alpha-amylase 1 reviewed AMY1A - - - -
reviewed BXGT005612 Pancreatic alpha-amylase reviewed AMY2 - 73900 - -
reviewed BXGT008083 Aldo-keto reductase family 1 member B1 reviewed Enzyme AKR1B1 - 2700 - -
CHEMBL CHEMBL312163
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P15121 BXGT008083 Aldo-keto reductase family 1 member B1 reviewed Enzyme AKR1B1 IC50 '=' 2700 nM
Q7ZJM1 BXGT017268 Integrase unreviewed - pol IC50 '=' 61600 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 19952 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 99 %
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 11220 nM
P04745 BXGT006255 Alpha-amylase 1 reviewed - AMY1A Inhibition '=' 8 %
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 2238 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 28183 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 28183 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Potency - 12589 nM
Q91Y86 BXGT019324 Mitogen-activated protein kinase 8 reviewed - Mapk8 Inhibition '=' 92 %
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 14125 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 14125 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 22387 nM
P04792 BXGT006264 Heat shock protein beta-1 reviewed - HSPB1 Activity - - -
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 19952 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 31622 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 31622 nM
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Activity - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 23 %
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 39810 nM
P04745 BXGT006255 Alpha-amylase 1 reviewed - AMY1A IC50 - - -
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 19952 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 19952 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Activity - - -
P10810 BXGT007618 Monocyte differentiation antigen CD14 reviewed - Cd14 Inhibition - - -
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 22387 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 31622 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency '=' 50118 nM
P45983 BXGT010494 Mitogen-activated protein kinase 8 reviewed Kinase MAPK8 Activity - - -
Q14576 BXGT013487 ELAV-like protein 3 reviewed - ELAVL3 IC50 '=' 1200 nM
Q7ZJM1 BXGT017268 Integrase unreviewed - pol IC50 '=' 28700 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 1995 nM
P53778 BXGT011013 Mitogen-activated protein kinase 12 reviewed Kinase MAPK12 Activity - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Activity - - -
Q15759 BXGT013595 Mitogen-activated protein kinase 11 reviewed Kinase MAPK11 Activity - - -
O15264 BXGT004144 Mitogen-activated protein kinase 13 reviewed Kinase MAPK13 Activity - - -
Q86831 BXGT017584 Polyprotein II unreviewed - Inhibition '=' 50 %
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 3981 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 5011 nM
Q28731 BXGT013954 Thrombin unreviewed - thrombin PT '=' 6 s
Q9Z1B7 BXGT022403 Mitogen-activated protein kinase 13 reviewed - Mapk13 Inhibition '=' 58 %
Q9WUI1 BXGT021940 Mitogen-activated protein kinase 11 reviewed - Mapk11 Inhibition '=' 58 %
O08911 BXGT004043 Mitogen-activated protein kinase 12 reviewed - Mapk12 Inhibition '=' 58 %
P47811 BXGT010587 Mitogen-activated protein kinase 14 reviewed - Mapk14 Inhibition '=' 58 %
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 3981 nM
Q91Y86 BXGT019324 Mitogen-activated protein kinase 8 reviewed - Mapk8 Inhibition '=' 64 %
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 946 nM
P45984 BXGT010495 Mitogen-activated protein kinase 9 reviewed Kinase MAPK9 Activity - - -
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 3 %
P00690 BXGT005612 Pancreatic alpha-amylase reviewed - AMY2 IC50 '=' 73900 nM
Q28731 BXGT013954 Thrombin unreviewed - thrombin Activity '=' 5 g/L
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 90 %
Q63844 BXGT016080 Mitogen-activated protein kinase 3 reviewed - Mapk3 Inhibition '=' 27 %
P53778 BXGT011013 Mitogen-activated protein kinase 12 reviewed Kinase MAPK12 K '=' 2 10'7/M
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 K '=' 2 10'7/M
Q15759 BXGT013595 Mitogen-activated protein kinase 11 reviewed Kinase MAPK11 K '=' 2 10'7/M
O15264 BXGT004144 Mitogen-activated protein kinase 13 reviewed Kinase MAPK13 K '=' 2 10'7/M
P45983 BXGT010494 Mitogen-activated protein kinase 8 reviewed Kinase MAPK8 K '=' 9 10'8/M
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency '=' 79432 nM
Q28731 BXGT013954 Thrombin unreviewed - thrombin TT '=' 23 s
Q28731 BXGT013954 Thrombin unreviewed - thrombin APTT '=' 72 s
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 39810 nM
Q9Z1B7 BXGT022403 Mitogen-activated protein kinase 13 reviewed - Mapk13 Inhibition '=' 51 %
Q9WUI1 BXGT021940 Mitogen-activated protein kinase 11 reviewed - Mapk11 Inhibition '=' 51 %
O08911 BXGT004043 Mitogen-activated protein kinase 12 reviewed - Mapk12 Inhibition '=' 51 %
P47811 BXGT010587 Mitogen-activated protein kinase 14 reviewed - Mapk14 Inhibition '=' 51 %
P03126 BXGT006024 Protein E6 reviewed - E6 Inhibition - - -
Q63844 BXGT016080 Mitogen-activated protein kinase 3 reviewed - Mapk3 Inhibition '=' 38 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00019 Tarragon Artemisia dracunculus Herbs and Spices
BXGF00061 Coriander Coriandrum sativum Herbs and Spices
BXGF00063 Saffron Crocus sativus Herbs and Spices
BXGF00139 Pepper (Spice) Piper nigrum Herbs and Spices
BXGF00179 Cloves Syzygium aromaticum Herbs and Spices
BXGF00440 Soursop Annona muricata Fruits
BXGF00911 Piper attenuatum Piper attenuatum Medicinal Plant
BXGF01104 Garcinia cambogia Garcinia cambogia Medicinal Plant
BXGF01252 Petasites laevigatus Petasites laevigatus Medicinal Plant
BXGF01324 Albizia julibrissin Albizia julibrissin Medicinal Plant
BXGF01370 Artemisia jacutica Artemisia jacutica Others
BXGF01404 Sphaeranthus confertifolius Sphaeranthus confertifolius Others
BXGF01556 Ornithoglossum viride Ornithoglossum viride Others
BXGF01606 Schizanthus tricolor Schizanthus tricolor Others
BXGF01631 Anodendron affine Anodendron affine Medicinal Plant
BXGF01669 Hertia cheirifolia Hertia cheirifolia Others
BXGF01696 Coptis japonica Coptis japonica Medicinal Plant
BXGF01720 Cedrela salvadorensis Cedrela salvadorensis Others
BXGF01727 Fraxinus ornus Fraxinus ornus Medicinal Plant
BXGF01858 Bersama abyssinica Bersama abyssinica Medicinal Plant
BXGF02403 Eucalyptus radiata Eucalyptus radiata Human Edible Plant
BXGF02441 Aconitum sajanense Aconitum sajanense Others
BXGF02870 Strychnos triplinervia Strychnos triplinervia Medicinal Plant
BXGF03312 Ajania fruticulosa Ajania fruticulosa Medicinal Plant
BXGF03498 Coptis deltoidea Coptis deltoidea Medicinal Plant
BXGF03610 Bistorta officinalis Bistorta officinalis Medicinal Plant
BXGF03782 Boehmeria pannosa Boehmeria pannosa Others
BXGF03892 Sesamum indicum Sesamum indicum 0
BXGF04046 Biancaea sappan Biancaea sappan Medicinal Plant
BXGF04105 Dipentodon sinicus Dipentodon sinicus Others
BXGF04130 Cirsium carolinianum Cirsium carolinianum Others
BXGF04224 Bistorta manshuriensis Bistorta manshuriensis Others
BXGF04230 Sigesbeckia pubescens Sigesbeckia pubescens Others
BXGF04254 Hypericum oblongifolium Hypericum oblongifolium Medicinal Plant
BXGF04271 Artemisia annua Artemisia annua Medicinal Plant
BXGF04768 Sigesbeckia glabrescens Sigesbeckia glabrescens Medicinal Plant
BXGF04784 Coptis teeta Coptis teeta Medicinal Plant
BXGF04785 Ilex taubertiana Ilex taubertiana Others
BXGF04889 Pogostemon cablin Pogostemon cablin Medicinal Plant
BXGF04910 Spinulum annotinum Spinulum annotinum Medicinal Plant
BXGF04972 Eugenia caryopyhllata Eugenia caryopyhllata Others
BXGF05013 Piper lanceifolium Piper lanceifolium Others
BXGF05254 Pericome caudata Pericome caudata Others
BXGF05286 Cassia jahnii Cassia jahnii Others
BXGF05379 Nervilia fordii Nervilia fordii Human Edible Plant
BXGF05436 Rubia tetragona Rubia tetragona Others
BXGF05506 Coptis chinensis Coptis chinensis Medicinal Plant
BXGF05626 Annona glabra Annona glabra Medicinal Plant
BXGF05718 Avrainvillea rawsonii Avrainvillea rawsonii Others
BXGF05809 Sonchus oleraceus Sonchus oleraceus Medicinal Plant
BXGF05858 Ormosia hosiei Ormosia hosiei Medicinal Plant
BXGF05874 Damnacanthus major Damnacanthus major Others
BXGF06052 Astragalus curvicarpus Astragalus curvicarpus Others
BXGF06063 Stauntonia hexaphylla Stauntonia hexaphylla Medicinal Plant
BXGF06224 Rubus sanctus Rubus sanctus Medicinal Plant
BXGF06250 Licaria chrysophylla Licaria chrysophylla Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease