Showing entry for cGMP-dependent protein kinase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013331
Protein NamecGMP-dependent protein kinase 2
Uniport IdQ13237
GenePRKG2
Gene Id5593
DomaincNMP_binding; Pkinase
Pfam PF00027   PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04540 Gap junction
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
5. Organismal Systems 5.10 Environmental adaptation hsa04713 Circadian entrainment
5. Organismal Systems 5.10 Environmental adaptation hsa04714 Thermogenesis
5. Organismal Systems 5.6 Nervous system hsa04730 Long-term depression
5. Organismal Systems 5.7 Sensory system hsa04740 Olfactory transduction
5. Organismal Systems 5.2 Endocrine system hsa04923 Regulation of lipolysis in adipocytes
5. Organismal Systems 5.2 Endocrine system hsa04924 Renin secretion
5. Organismal Systems 5.4 Digestive system hsa04970 Salivary secretion
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:2001226 negative regulation of chloride transport
Biological Process GO:0036289 peptidyl-serine autophosphorylation
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0007165 signal transduction
molecular function GO:0005524 ATP binding
molecular function GO:0030553 cGMP binding
molecular function GO:0004692 cGMP-dependent protein kinase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0004672 protein kinase activity
cellular component GO:0016324 apical plasma membrane
cellular component GO:0005829 cytosol
cellular component GO:0031965 nuclear membrane
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-109582 Hemostasis
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1430728 Metabolism
R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-168256 Immune System
R-HSA-195721 Signaling by WNT
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-3858494 Beta-catenin independent WNT signaling
R-HSA-392154 Nitric oxide stimulates guanylate cyclase
R-HSA-392154 Nitric oxide stimulates guanylate cyclase
R-HSA-4086398 Ca2+ pathway
R-HSA-418346 Platelet homeostasis
R-HSA-418346 Platelet homeostasis
R-HSA-418457 cGMP effects
R-HSA-418457 cGMP effects
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-8978934 Metabolism of cofactors
R-HSA-9607240 FLT3 Signaling
R-HSA-9648002 RAS processing
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001726 BXGD000072 Affective Symptoms Behavior and Behavior Mechanisms
C0005890 BXGD000345 Body Height
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0018099 BXGD001172 Gout Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0023461 BXGD001653 Leukemia, Mast-Cell Neoplasms
C0027022 BXGD001962 Myeloproliferative disease Hemic and Lymphatic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0221013 BXGD004363 Mastocytosis, Systemic Neoplasms; Immune System Diseases
C0221292 BXGD004440 Basophilic leukemia Neoplasms
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0489786 BXGD009018 Height
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0678909 BXGD009757 Brain Waves
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0740394 BXGD009989 Hyperuricemia Pathological Conditions, Signs and Symptoms
C0747845 BXGD010184 early pregnancy
C0871470 BXGD011316 Systolic Pressure
C1290807 BXGD012195 Diarrheal disorder Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C1319315 BXGD012415 Adenocarcinoma of large intestine Digestive System Diseases; Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000988 3' 5'-cyclic AMP 329.21
BXGC0002586 Calcium 40.08
BXGC0002708 Strontium 87.62
BXGC0004188 Propanedioic acid 104.06
BXGC0036634 Cgmp 345.05
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein