Showing entry for T-cell surface glycoprotein CD4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005781
Protein NameT-cell surface glycoprotein CD4
Uniport IdP01730
GeneCD4
Gene Id920
DomainC2-set; CD4-extracel; ig; Tcell_CD4_C
Pfam PF05790   PF09191   PF00047   PF12104  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04514 Cell adhesion molecules (CAMs)
5. Organismal Systems 5.1 Immune system hsa04612 Antigen processing and presentation
5. Organismal Systems 5.1 Immune system hsa04640 Hematopoietic cell lineage
5. Organismal Systems 5.1 Immune system hsa04658 Th1 and Th2 cell differentiation
5. Organismal Systems 5.1 Immune system hsa04659 Th17 cell differentiation
5. Organismal Systems 5.1 Immune system hsa04660 T cell receptor signaling pathway
6. Human Diseases 6.9 Infectious diseases: Viral hsa05166 Human T-cell leukemia virus 1 infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05170 Human immunodeficiency virus 1 infection
6. Human Diseases 6.1 Cancers: Overview hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
6. Human Diseases 6.3 Immune diseases hsa05340 Primary immunodeficiency
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0007155 cell adhesion
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0001816 cytokine production
Biological Process GO:0050829 defense response to Gram-negative bacterium
Biological Process GO:0007167 enzyme linked receptor protein signaling pathway
Biological Process GO:0019064 fusion of virus membrane with host plasma membrane
Biological Process GO:0035397 helper T cell enhancement of adaptive immune response
Biological Process GO:0006955 immune response
Biological Process GO:0006948 induction by virus of host cell-cell fusion
Biological Process GO:0035723 interleukin-15-mediated signaling pathway
Biological Process GO:0030225 macrophage differentiation
Biological Process GO:0032507 maintenance of protein location in cell
Biological Process GO:0061024 membrane organization
Biological Process GO:0010524 positive regulation of calcium ion transport into cytosol
Biological Process GO:0050850 positive regulation of calcium-mediated signaling
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0032743 positive regulation of interleukin-2 production
Biological Process GO:0033674 positive regulation of kinase activity
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:0045657 positive regulation of monocyte differentiation
Biological Process GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:0045860 positive regulation of protein kinase activity
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0042102 positive regulation of T cell proliferation
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0046598 positive regulation of viral entry into host cell
Biological Process GO:0051924 regulation of calcium ion transport
Biological Process GO:0050690 regulation of defense response to virus by virus
Biological Process GO:0050863 regulation of T cell activation
Biological Process GO:0032355 response to estradiol
Biological Process GO:0033280 response to vitamin D
Biological Process GO:0007165 signal transduction
Biological Process GO:0042110 T cell activation
Biological Process GO:0030217 T cell differentiation
Biological Process GO:0050852 T cell receptor signaling pathway
Biological Process GO:0045058 T cell selection
Biological Process GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
molecular function GO:0015026 coreceptor activity
molecular function GO:0019899 enzyme binding
molecular function GO:0005201 extracellular matrix structural constituent
molecular function GO:0042802 identical protein binding
molecular function GO:0019865 immunoglobulin binding
molecular function GO:0042011 interleukin-16 binding
molecular function GO:0042012 interleukin-16 receptor activity
molecular function GO:0042289 MHC class II protein binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0019901 protein kinase binding
molecular function GO:1990782 protein tyrosine kinase binding
molecular function GO:0038023 signaling receptor activity
molecular function GO:0004888 transmembrane signaling receptor activity
molecular function GO:0001618 virus receptor activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0030665 clathrin-coated vesicle membrane
cellular component GO:0005769 early endosome
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0045121 membrane raft
cellular component GO:0005886 plasma membrane
cellular component GO:0042101 T cell receptor complex
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280218 Adaptive Immune System
R-HSA-1461973 Defensins
R-HSA-1462054 Alpha-defensins
R-HSA-162587 HIV Life Cycle
R-HSA-162594 Early Phase of HIV Life Cycle
R-HSA-162906 HIV Infection
R-HSA-162909 Host Interactions of HIV factors
R-HSA-1643685 Disease
R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis
R-HSA-167590 Nef Mediated CD4 Down-regulation
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-173107 Binding and entry of HIV virion
R-HSA-180534 Vpu mediated degradation of CD4
R-HSA-199991 Membrane Trafficking
R-HSA-202403 TCR signaling
R-HSA-202424 Downstream TCR signaling
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse
R-HSA-202433 Generation of second messenger molecules
R-HSA-388841 Costimulation by the CD28 family
R-HSA-389948 PD-1 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-449836 Other interleukin signaling
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5663205 Infectious disease
R-HSA-6803157 Antimicrobial peptides
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001175 BXGD000029 Acquired Immunodeficiency Syndrome Infections; Immune System Diseases
C0003869 BXGD000234 Arthritis, Infectious Infections; Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013264 BXGD000808 Muscular Dystrophy, Duchenne Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0014072 BXGD000888 Experimental Autoimmune Encephalomyelitis Immune System Diseases; Nervous System Diseases
C0014457 BXGD000915 Eosinophilia Hemic and Lymphatic Diseases
C0018129 BXGD001175 Graft Rejection
C0018133 BXGD001176 Graft-vs-Host Disease Immune System Diseases
C0018671 BXGD001211 Head and Neck Neoplasms Neoplasms
C0019159 BXGD001294 Hepatitis A Digestive System Diseases; Infections
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020241 BXGD001368 Hydroa Vacciniforme Skin and Connective Tissue Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024312 BXGD001766 Lymphopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027746 BXGD002032 Nerve Degeneration Pathological Conditions, Signs and Symptoms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0030305 BXGD002206 Pancreatitis Digestive System Diseases
C0032231 BXGD002339 Pleurisy Infections; Respiratory Tract Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036920 BXGD002645 Sezary Syndrome Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0037023 BXGD002660 Sialadenitis Stomatognathic Diseases
C0037221 BXGD002673 Situs Inversus Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0038826 BXGD002779 Superinfection Infections
C0042769 BXGD002999 Virus Diseases Infections
C0042900 BXGD003012 Vitiligo Skin and Connective Tissue Diseases
C0078911 BXGD003053 AIDS-Associated Nephropathy Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases; Immune System Diseases
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0155877 BXGD003830 Allergic asthma Respiratory Tract Diseases; Immune System Diseases
C0157843 BXGD003865 Infective arthritis of shoulder region Infections; Musculoskeletal Diseases
C0157844 BXGD003866 Unspecified infective arthritis involving upper arm Infections; Musculoskeletal Diseases
C0157845 BXGD003867 Unspecified infective arthritis involving forearm Infections; Musculoskeletal Diseases
C0157846 BXGD003868 Unspecified infective arthritis involving hand Infections; Musculoskeletal Diseases
C0157847 BXGD003869 Unspecified infective arthritis, pelvic region and thigh Infections; Musculoskeletal Diseases
C0157848 BXGD003870 Unspecified infective arthritis involving lower leg Infections; Musculoskeletal Diseases
C0157849 BXGD003871 Unspecified infective arthritis, ankle and foot Infections; Musculoskeletal Diseases
C0162526 BXGD003947 AIDS-Related Opportunistic Infections Infections; Immune System Diseases
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202236 BXGD004086 Triglycerides measurement
C0221163 BXGD004395 Motor Disorders Mental Disorders
C0266929 BXGD005722 Chronic Periodontitis Stomatognathic Diseases
C0276501 BXGD006427 Human immunodeficiency virus II infection Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases; Immune System Diseases
C0339303 BXGD007239 Corneal graft rejection Eye Diseases
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0812413 BXGD010847 Malignant Pleural Mesothelioma Neoplasms; Respiratory Tract Diseases
C0854094 BXGD010998 HIV-2 infection Infections; Immune System Diseases
C0917713 BXGD011404 Becker Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1306759 BXGD012374 Eosinophilic disorder Hemic and Lymphatic Diseases
C1445957 BXGD013081 Serum total cholesterol measurement
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1504514 BXGD013146 Infection by human herpesvirus 7 Infections
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1847835 BXGD014892 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) Skin and Connective Tissue Diseases
C1855752 BXGD015539 Abnormality of T cells
C2363741 BXGD017100 HIV-1 infection
C3151379 BXGD018419 OKT4 EPITOPE DEFICIENCY
C3542021 BXGD019101 Duchenne and Becker Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C3714514 BXGD019409 Infection Infections
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4048329 BXGD021904 Immunosuppression
C4050064 BXGD021958 ROSE Cluster 5
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0004188 Propanedioic acid 104.06
BXGC0004266 2-Propanol 60.1
BXGC0004275 Acetaldehyde 44.05
BXGC0035519 Amygdalin 457.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein