Showing entry for Moracin M


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0005310
Compound NameMoracin M
Structure
FormulaC14H10O4
InchiKeyLHPRYOJTASOZGJ-UHFFFAOYSA-N
SMILESOC1=CC=C2C=C(OC2=C1)C1=CC(O)=CC(O)=C1
InchiInChI=1S/C14H10O4/c15-10-2-1-8-5-13(18-14(8)7-10)9-3-11(16)6-12(17)4-9/h1-7,15-17H
IUPAC5-(6-hydroxy-1-benzofuran-2-yl)benzene-1,3-diol
Molecular Weight242.23
Pubchem Id185848
Chembl IdCHEMBL512578
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50250915
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed PDE5A - >40000 - -
reviewed BXGT005592 Pancreatic triacylglycerol lipase reviewed PNLIP - >70000 - -
reviewed BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 - 500 - -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 - 22300 - -
reviewed BXGT005176 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A reviewed PDE9A - >100000 - -
reviewed BXGT012988 cAMP-specific 3',5'-cyclic phosphodiesterase 4D reviewed PDE4D - 2900 - -
reviewed BXGT012926 cAMP-specific 3',5'-cyclic phosphodiesterase 4B reviewed PDE4B - 4500 - -
CHEMBL CHEMBL512578
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q9H0H5 BXGT020436 Rac GTPase-activating protein 1 reviewed Enzyme modulator RACGAP1 IC50 - 23000 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Activity '=' 60 %
Q03431 BXGT012714 Parathyroid hormone/parathyroid hormone-related peptide receptor reviewed G-protein coupled receptor PTH1R Potency - 50118 nM
P17405 BXGT008304 Sphingomyelin phosphodiesterase reviewed Enzyme SMPD1 Potency - 25118 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '=' 22300 nM
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 '=' 500 nM
Q63470 BXGT016073 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed - Dyrk1a AC50 '=' 6146 nM
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha reviewed Transcription factor HIF1A IC50 '>' 50000 nM
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A IC50 '>' 40000 nM
Q9HCT0 BXGT020538 Fibroblast growth factor 22 reviewed Signaling FGF22 AbsAC1 '=' 14 uM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 62 %
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 56234 nM
Q08499 BXGT012988 cAMP-specific 3',5'-cyclic phosphodiesterase 4D reviewed - PDE4D IC50 '=' 2910 nM
Q08499 BXGT012988 cAMP-specific 3',5'-cyclic phosphodiesterase 4D reviewed - PDE4D IC50 '=' 2900 nM
Q07343 BXGT012926 cAMP-specific 3',5'-cyclic phosphodiesterase 4B reviewed - PDE4B IC50 '=' 4500 nM
O76083 BXGT005176 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A reviewed - PDE9A IC50 '>' 100000 nM
Q99814 BXGT019965 Endothelial PAS domain-containing protein 1 reviewed Transcription factor EPAS1 IC50 '>' 30000 nM
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha reviewed Transcription factor HIF1A IC50 '>' 30000 nM
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha reviewed Transcription factor HIF1A IC50 - - -
P00591 BXGT005592 Pancreatic triacylglycerol lipase reviewed - PNLIP IC50 '>' 70000 nM
P11511 BXGT007717 Aromatase reviewed Enzyme CYP19A1 IC50 '>' 40 ug.mL-1
Q8WZA2 BXGT019025 Rap guanine nucleotide exchange factor 4 reviewed Enzyme modulator RAPGEF4 Potency - 39810 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '=' 43 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29092 nM
P00591 BXGT005592 Pancreatic triacylglycerol lipase reviewed - PNLIP Inhibition '=' 21 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00823 Fruits Fruits
BXGF00947 Artocarpus dadah Artocarpus dadah Medicinal Plant
BXGF01228 Ageratina adenophora Ageratina adenophora Medicinal Plant
BXGF03318 Capsicum tetragonum Capsicum tetragonum Others
BXGF03934 Lycoris traubii Lycoris traubii Others
BXGF04053 Smilax china Smilax china Medicinal Plant
BXGF04350 Lygodium flexuosum Lygodium flexuosum Medicinal Plant
BXGF04607 Morus alba Morus alba Medicinal Plant
BXGF04709 Strychnos staudtii Strychnos staudtii Others
BXGF04727 Dictyoloma incanescens Dictyoloma incanescens Others
BXGF04738 Saccharum spontaneum Saccharum spontaneum Medicinal Plant
BXGF04746 Crotalaria anagyroides Crotalaria anagyroides Medicinal Plant
BXGF04778 Dasymaschalon sootepense Dasymaschalon sootepense Others
BXGF04782 Croton poilanei Croton poilanei Others
BXGF04794 Tsuga mertensiana Tsuga mertensiana Medicinal Plant
BXGF04820 Panax ginseng Panax ginseng 0
BXGF04834 Guatteria melosma Guatteria melosma Others
BXGF04860 Securinega melanthesoides Securinega melanthesoides Others
BXGF04865 Euonymus sachalinensis Euonymus sachalinensis Medicinal Plant
BXGF04870 Felicia erigeroides Felicia erigeroides Others
BXGF04879 Lupinus paniculatus Lupinus paniculatus Others
BXGF04886 Boehmeria nivea Boehmeria nivea Medicinal Plant
BXGF05049 arundina gramnifolia arundina gramnifolia Others
BXGF05476 Broussonetia papyrifera Broussonetia papyrifera Medicinal Plant
BXGF06007 Canthium berberidifolium Canthium berberidifolium Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease