Showing entry for High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005176
Protein NameHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Uniport IdO76083
GenePDE9A
Gene Id5152
DomainPDEase_I
Pfam PF00233  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0046069 cGMP catabolic process
Biological Process GO:0019934 cGMP-mediated signaling
Biological Process GO:0046068 cGMP metabolic process
Biological Process GO:0010613 positive regulation of cardiac muscle hypertrophy
Biological Process GO:0007165 signal transduction
molecular function GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
molecular function GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0046872 metal ion binding
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005794 Golgi apparatus
cellular component GO:0043204 perikaryon
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0032587 ruffle membrane
cellular component GO:0042383 sarcolemma
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-392154 Nitric oxide stimulates guanylate cyclase
R-HSA-418346 Platelet homeostasis
R-HSA-418457 cGMP effects
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006111 BXGD000369 Brain Diseases Nervous System Diseases
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011269 BXGD000710 Dementia, Vascular Nervous System Diseases; Mental Disorders; Cardiovascular Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001502 Caffeine 194.19
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
BXGC0005310 Moracin M 242.23
BXGC0005313 Moracin C 310.34
BXGC0006368 Formic acid 46.03
BXGC0027925 Cpg 363.06
BXGC0036634 Cgmp 345.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein