Showing entry for Rac GTPase-activating protein 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020436
Protein NameRac GTPase-activating protein 1
Uniport IdQ9H0H5
GeneRACGAP1
Gene Id29127
DomainC1_1; RhoGAP
Pfam PF00130   PF00620  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000915 actomyosin contractile ring assembly
Biological Process GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0007018 microtubule-based movement
Biological Process GO:0000281 mitotic cytokinesis
Biological Process GO:0051256 mitotic spindle midzone assembly
Biological Process GO:0007405 neuroblast proliferation
Biological Process GO:0032467 positive regulation of cytokinesis
Biological Process GO:0051988 regulation of attachment of spindle microtubules to kinetochore
Biological Process GO:0045995 regulation of embryonic development
Biological Process GO:0051056 regulation of small GTPase mediated signal transduction
Biological Process GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
Biological Process GO:0007283 spermatogenesis
Biological Process GO:0008272 sulfate transport
molecular function GO:0043014 alpha-tubulin binding
molecular function GO:0048487 beta-tubulin binding
molecular function GO:0043015 gamma-tubulin binding
molecular function GO:0005096 GTPase activator activity
molecular function GO:0046872 metal ion binding
molecular function GO:0008017 microtubule binding
molecular function GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
molecular function GO:0019901 protein kinase binding
cellular component GO:0001669 acrosomal vesicle
cellular component GO:0097149 centralspindlin complex
cellular component GO:0032154 cleavage furrow
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
cellular component GO:0090543 Flemming body
cellular component GO:0005874 microtubule
cellular component GO:0030496 midbody
cellular component GO:0072686 mitotic spindle
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0051233 spindle midzone
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-1280218 Adaptive Immune System
R-HSA-162582 Signal Transduction
R-HSA-168256 Immune System
R-HSA-194315 Signaling by Rho GTPases
R-HSA-194840 Rho GTPase cycle
R-HSA-199991 Membrane Trafficking
R-HSA-2132295 MHC class II antigen presentation
R-HSA-5653656 Vesicle-mediated transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-8856688 Golgi-to-ER retrograde transport
R-HSA-983189 Kinesins
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007140 BXGD000447 Carcinosarcoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0280630 BXGD006751 Uterine Carcinosarcoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0280801 BXGD006765 Grade III Meningioma Neoplasms; Nervous System Diseases
C0341439 BXGD007408 Chronic liver disease Digestive System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0403824 BXGD008316 Teratozoospermia Male Urogenital Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1136382 BXGD011717 Sclerocystic Ovaries Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1153706 BXGD011769 Endometrial adenocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1704376 BXGD013552 Uterine Corpus Carcinosarcoma
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2347749 BXGD017042 Adult Grade III Meningioma
C2347758 BXGD017046 Childhood Grade III Meningioma
C3642347 BXGD019246 Basal-Like Breast Carcinoma
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000340 Kaempferol 286.24
BXGC0000436 Glycerol 92.09
BXGC0001167 Isoorientin 7-O-(6'''-O-(E)-feruloyl)glucoside 448.38
BXGC0001174 Xanthoangelol H 354.4
BXGC0001747 Rosmarinic acid 360.31
BXGC0001899 Daidzein 254.24
BXGC0002690 alpha-Catechin 290.27
BXGC0003066 Phenols 199.27
BXGC0003696 Quercetin 3-O-methyl-ether 316.26
BXGC0005310 Moracin M 242.23
BXGC0005502 Coumestrol 268.22
BXGC0006062 Isoorientin 448.38
BXGC0017158 thunberginol A 270.05
BXGC0017933 Sulfuretin 270.05
BXGC0020818 Pinoresinol 358.14
BXGC0025066 Benzidine 184.1
BXGC0027644 2-(3,4-Dihydroxyphenyl)-5-Hydroxy-7-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyloxan-2-Yl]Oxymethyl]Oxan-2-Yl]Oxychromen-4-One 594.16
BXGC0039019 Harmol 198.08
BXGC0040936 Sid26657808 284.07
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein