Showing entry for Dual specificity tyrosine-phosphorylation-regulated kinase 1A


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT016073
Protein NameDual specificity tyrosine-phosphorylation-regulated kinase 1A
Uniport IdQ63470
GeneDyrk1a
Gene Id25255
DomainPkinase
Pfam PF00069  
OrganismRattus norvegicus (Rat)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0034205 amyloid-beta formation
Biological Process GO:0007623 circadian rhythm
Biological Process GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
Biological Process GO:0031115 negative regulation of microtubule polymerization
Biological Process GO:0048025 negative regulation of mRNA splicing, via spliceosome
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0018107 peptidyl-threonine phosphorylation
Biological Process GO:0038083 peptidyl-tyrosine autophosphorylation
Biological Process GO:0018108 peptidyl-tyrosine phosphorylation
Biological Process GO:0090312 positive regulation of protein deacetylation
Biological Process GO:0033120 positive regulation of RNA splicing
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0000381 regulation of alternative mRNA splicing, via spliceosome
molecular function GO:0003779 actin binding
molecular function GO:0005524 ATP binding
molecular function GO:0008092 cytoskeletal protein binding
molecular function GO:0042802 identical protein binding
molecular function GO:0004715 non-membrane spanning protein tyrosine kinase activity
molecular function GO:0004672 protein kinase activity
molecular function GO:0043621 protein self-association
molecular function GO:0004712 protein serine/threonine/tyrosine kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0004713 protein tyrosine kinase activity
molecular function GO:0048156 tau protein binding
molecular function GO:0003713 transcription coactivator activity
molecular function GO:0015631 tubulin binding
cellular component GO:0030424 axon
cellular component GO:0005737 cytoplasm
cellular component GO:0005856 cytoskeleton
cellular component GO:0030425 dendrite
cellular component GO:0016607 nuclear speck
cellular component GO:0005634 nucleus
cellular component GO:1990904 ribonucleoprotein complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000340 Kaempferol 286.24
BXGC0001495 (R)-Roemerine 279.33
BXGC0001498 Boldine 327.37
BXGC0001544 Harmaline 214.26
BXGC0001545 Harmine 212.25
BXGC0001742 Eupafolin 316.26
BXGC0001842 Bergapten 216.19
BXGC0001889 p-Coumaric acid 164.16
BXGC0001954 trans-p-Methoxycinnamic acid 178.18
BXGC0003048 Kaempferol 3-rhamno-glucoside 594.52
BXGC0003221 Xanthyletin 228.24
BXGC0003273 3-O-Methylkaempferol 300.26
BXGC0004115 Norharman 168.19
BXGC0005310 Moracin M 242.23
BXGC0005793 Baicalein 270.24
BXGC0005945 2'-Hydroxygenistein 286.24
BXGC0007368 Luteolin 7-glucoside 448.38
BXGC0008824 Astragalin 448.38
BXGC0011280 Isothymonin 360.31
BXGC0012236 Quercetin 3-alpha-D-galactoside 464.38
BXGC0017933 Sulfuretin 270.05
BXGC0020870 5,7-Dihydroxy-2-(4-Hydroxy-3-Methoxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-[[(3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyloxan-2-Yl]Oxymethyl]Oxan-2-Yl]Oxychromen-4-One 624.17
BXGC0021666 dicentrine 339.15
BXGC0021855 4-[(2R)-2-Hydroxy-3-Methylbut-3-Enoxy]Furo[3,2-G]Chromen-7-One 286.08
BXGC0026681 2-(3,4-Dihydroxyphenyl)-5,7-Dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyloxan-2-Yl]Oxymethyl]Oxan-2-Yl]Oxychromen-4-One;Hydrate 610.15
BXGC0027644 2-(3,4-Dihydroxyphenyl)-5-Hydroxy-7-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyloxan-2-Yl]Oxymethyl]Oxan-2-Yl]Oxychromen-4-One 594.16
BXGC0029807 Anisocoumarin H 314.15
BXGC0030690 Savinin 352.09
BXGC0033310 Epigalocatechin Gallate 458.08
BXGC0034049 3-[(2S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]Oxy-2-(3,4-Dihydroxyphenyl)-5,7-Dihydroxychromen-4-One 434.08
BXGC0039019 Harmol 198.08
BXGC0039397 Athraquinones A 240.04
BXGC0040779 Gerontoxanthone I 396.16
BXGC0040936 Sid26657808 284.07
BXGC0041195 Boldine 327.15
BXGC0042870 Piceatannol 244.07
BXGC0050726 5,7-Dihydroxy-2-(4-Hydroxyphenyl)-3-[(2R,3S,4R,5R,6S)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxychromen-4-One 448.1
BXGC0051184 Calycosin 284.07
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein