Showing entry for Rap guanine nucleotide exchange factor 4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019025
Protein NameRap guanine nucleotide exchange factor 4
Uniport IdQ8WZA2
GeneRAPGEF4
Gene Id11069
DomaincNMP_binding; DEP; RasGEF; RasGEF_N
Pfam PF00027   PF00610   PF00617   PF00618  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04015 Rap1 signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04072 Phospholipase D signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
5. Organismal Systems 5.1 Immune system hsa04670 Leukocyte transendothelial migration
5. Organismal Systems 5.2 Endocrine system hsa04911 Insulin secretion
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0017156 calcium-ion regulated exocytosis
Biological Process GO:0019933 cAMP-mediated signaling
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0030073 insulin secretion
Biological Process GO:0017157 regulation of exocytosis
Biological Process GO:0050796 regulation of insulin secretion
Biological Process GO:0098693 regulation of synaptic vesicle cycle
Biological Process GO:0007264 small GTPase mediated signal transduction
molecular function GO:0030552 cAMP binding
molecular function GO:0005085 guanyl-nucleotide exchange factor activity
molecular function GO:0017016 Ras GTPase binding
molecular function GO:0005088 Ras guanyl-nucleotide exchange factor activity
cellular component GO:0005829 cytosol
cellular component GO:0098686 hippocampal mossy fiber to CA3 synapse
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-1280218 Adaptive Immune System
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction
R-HSA-163685 Integration of energy metabolism
R-HSA-168256 Immune System
R-HSA-354192 Integrin signaling
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392517 Rap1 signalling
R-HSA-422356 Regulation of insulin secretion
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-76009 Platelet Aggregation (Plug Formation)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006271 BXGD000384 Bronchiolitis Infections; Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0025202 BXGD001832 melanoma Neoplasms
C0026654 BXGD001914 Moyamoya Disease Nervous System Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0032617 BXGD002367 Polyuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0040479 BXGD002870 Torsades de Pointes Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085632 BXGD003215 Apathy Behavior and Behavior Mechanisms
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0206682 BXGD004237 Follicular thyroid carcinoma Neoplasms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0375023 BXGD007970 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0596887 BXGD009648 mathematical ability
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2931367 BXGD018010 Thyroid cancer, follicular Neoplasms
C2931384 BXGD018014 Moyamoya disease 1 Nervous System Diseases; Cardiovascular Diseases
C2939186 BXGD018176 Disturbance in mood Mental Disorders
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000324 Isovitexin 432.38
BXGC0000511 1,4-Dimethoxybenzene 138.16
BXGC0000952 6-Oxocamphor 457.91
BXGC0000988 3' 5'-cyclic AMP 329.21
BXGC0001078 Xanthoangelol E 370.4
BXGC0001200 3-Hydroxy-4-isopentenyl-5-methoxybibenzyl-2-carboxylic acid 340.41
BXGC0001325 Progesterone 314.46
BXGC0001497 Berberrubine 322.33
BXGC0001733 Tangeritin 372.37
BXGC0001767 (E)-Resveratrol 228.25
BXGC0001782 Sennoside B 862.74
BXGC0001820 Osthol 244.29
BXGC0001879 Chlorogenic acid 354.31
BXGC0002248 Dodecanoic acid 200.32
BXGC0002781 Flavonoids 224.25
BXGC0002957 di-(2-Methylpropyl)-phthalate 278.34
BXGC0004132 Zosimin 328.36
BXGC0004574 Eugenyl benzoate 268.31
BXGC0004823 Bis(2-methylpropanoyloxy)-9,10-epoxy-p-mentha-1,3,5-triene 320.38
BXGC0004955 N-Phenyl-2-naphthylamine 219.28
BXGC0005254 Dibutyl phthalate 278.34
BXGC0005310 Moracin M 242.23
BXGC0005428 Graveoline 279.29
BXGC0005721 Bisdemethoxycurcumin 308.33
BXGC0005981 (S)-4',5,7-Trihydroxy-8-prenylflavanone 340.38
BXGC0006193 Ellagic acid 302.19
BXGC0006306 Myricetin 318.24
BXGC0006466 Oleanolic acid 456.71
BXGC0007003 Semilicoisoflavone B 352.34
BXGC0008198 7-Isopropyl-1,4-dimethylazulene 198.3
BXGC0008667 6-Prenylnaringenin 340.38
BXGC0009332 Pelanin 356.5
BXGC0010427 Xanthotoxol geranyl ether 338.4
BXGC0012702 (4As,6As,6Br,10S,12Ar)-10-Hydroxy-2,2,6A,6B,9,9,12A-Heptamethyl-1,3,4,5,6,6A,7,8,8A,10,11,12,13,14B-Tetradecahydropicene-4A-Carboxylic Acid 456.36
BXGC0012874 Continentalic acid 302.22
BXGC0013582 Curcumin 368.13
BXGC0014768 Lanatoside C 984.49
BXGC0015879 Chlorhexidine 504.2
BXGC0016454 1-methoxyphaseollidin 354.15
BXGC0016854 cytisine 190.11
BXGC0016991 Squamatic acid 390.1
BXGC0018071 Totarol 286.23
BXGC0020847 Butyl 2-(2,4-Dichlorophenoxy)Acetate 276.03
BXGC0021836 Honokiol 266.13
BXGC0022009 (9R)-9-[(9R)-2-Carboxy-4-Hydroxy-10-Oxo-5-[(3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-9H-Anthracen-9-Yl]-4-Hydroxy-10-Oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-9H-Anthracene-2-Carboxylic Acid 862.2
BXGC0023633 Kamebanin 334.21
BXGC0023895 (1R,4Ar,7R)-7-Ethenyl-1,4A,7-Trimethyl-3,4,4B,5,6,9,10,10A-Octahydro-2H-Phenanthrene-1-Carboxylic Acid 302.22
BXGC0024086 Gomisin M2 386.17
BXGC0024331 7-O-Ac-afromosin 340.09
BXGC0024428 3-(1H-Benzimidazol-2-Yl)-7-(Diethylamino)Chromen-2-One 333.15
BXGC0024489 Licarin A 326.15
BXGC0024770 Digoxigenin 390.24
BXGC0026109 Nelumol A 346.21
BXGC0026480 Osajin 404.16
BXGC0026607 epiberberine 336.12
BXGC0027288 Schisandrin A 416.22
BXGC0027639 sanggenon A 436.15
BXGC0029205 Sphaeropsidin A 346.18
BXGC0029721 Sclerotiorin 390.12
BXGC0030879 Mesodihydroguaiaretic Acid 330.18
BXGC0031002 Diffractaic Acid 374.14
BXGC0031659 delta-Tocopherol 402.35
BXGC0033577 Interiotherin C 556.23
BXGC0034894 Oleic Acid 282.26
BXGC0034968 Dienestrol 266.13
BXGC0035226 Betulinic Acid 456.36
BXGC0036632 Austrobailignan 6 328.17
BXGC0036805 Butylated Hydroxyanisole 180.12
BXGC0038577 Magnolol 266.13
BXGC0038895 Emodic Acid 300.03
BXGC0040358 Lobaric Acid 456.18
BXGC0041080 Pilosanone B 336.23
BXGC0042035 raubasine 352.18
BXGC0042211 4-Octylphenol 206.17
BXGC0042870 Piceatannol 244.07
BXGC0043875 Karanjin 292.07
BXGC0044333 12-Phenyldodecanoic Acid 276.21
BXGC0046681 Ponasterone A 464.31
BXGC0047088 Ursolic Acid 456.36
BXGC0049758 Corosolic Acid 472.36
BXGC0051013 N-Phenylnaphthalen-1-Amine 219.1
BXGC0051541 pterosin B 218.13
BXGC0051756 [8,8-Dimethyl-9-[(Z)-2-Methylbut-2-Enoyl]Oxy-2-Oxo-9,10-Dihydropyrano[2,3-F]Chromen-10-Yl] (Z)-2-Methylbut-2-Enoate 426.17
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein