Showing entry for cAMP-specific 3',5'-cyclic phosphodiesterase 4B


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012926
Protein NamecAMP-specific 3',5'-cyclic phosphodiesterase 4B
Uniport IdQ07343
GenePDE4B
Gene Id5142
DomainPDE4_UCR; PDEase_I
Pfam PF18100   PF00233  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04928 Parathyroid hormone synthesis, secretion and action
6. Human Diseases 6.5 Substance dependence hsa05032 Morphine addiction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006198 cAMP catabolic process
Biological Process GO:0035690 cellular response to drug
Biological Process GO:0071872 cellular response to epinephrine stimulus
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0050900 leukocyte migration
Biological Process GO:1901898 negative regulation of relaxation of cardiac muscle
Biological Process GO:0030593 neutrophil chemotaxis
Biological Process GO:0001780 neutrophil homeostasis
Biological Process GO:0032729 positive regulation of interferon-gamma production
Biological Process GO:0032743 positive regulation of interleukin-2 production
Biological Process GO:0086004 regulation of cardiac muscle cell contraction
Biological Process GO:1901841 regulation of high voltage-gated calcium channel activity
Biological Process GO:0050852 T cell receptor signaling pathway
molecular function GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
molecular function GO:0030552 cAMP binding
molecular function GO:0043015 gamma-tubulin binding
molecular function GO:0044325 ion channel binding
molecular function GO:0046872 metal ion binding
cellular component GO:0005813 centrosome
cellular component GO:0005829 cytosol
cellular component GO:0043197 dendritic spine
cellular component GO:0060076 excitatory synapse
cellular component GO:0000930 gamma-tubulin complex
cellular component GO:0014069 postsynaptic density
cellular component GO:0008021 synaptic vesicle
cellular component GO:0005891 voltage-gated calcium channel complex
cellular component GO:0030018 Z disc
Reactome
Pathway Id Pathway Name
R-HSA-111885 Opioid Signalling
R-HSA-162582 Signal Transduction
R-HSA-180024 DARPP-32 events
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001430 BXGD000054 Adenoma Neoplasms
C0001956 BXGD000092 Alcohol Use Disorder Chemically-Induced Disorders; Mental Disorders
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003872 BXGD000235 Arthritis, Psoriatic Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005587 BXGD000316 Depression, Bipolar Mental Disorders
C0005612 BXGD000317 Birth Weight Pathological Conditions, Signs and Symptoms
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006625 BXGD000401 Cachexia Pathological Conditions, Signs and Symptoms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007682 BXGD000471 CNS disorder Nervous System Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024713 BXGD001799 Manic Disorder Mental Disorders
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026998 BXGD001959 Acute Myeloid Leukemia, M1 Neoplasms
C0027404 BXGD001984 Narcolepsy Nervous System Diseases; Mental Disorders
C0027498 BXGD001994 Nausea and vomiting Pathological Conditions, Signs and Symptoms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030319 BXGD002208 Panic Disorder Mental Disorders
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0035204 BXGD002511 Respiration Disorders Respiratory Tract Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0037369 BXGD002691 Smoking Behavior and Behavior Mechanisms
C0038160 BXGD002734 Staphylococcal Infections Infections
C0038663 BXGD002778 Suicide attempt Behavior and Behavior Mechanisms
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0042514 BXGD002989 Tachycardia, Ventricular Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085612 BXGD003204 Ventricular arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085762 BXGD003251 Alcohol abuse Chemically-Induced Disorders; Mental Disorders
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0155877 BXGD003830 Allergic asthma Respiratory Tract Diseases; Immune System Diseases
C0162830 BXGD003987 Dermatitis, Phototoxic Skin and Connective Tissue Diseases
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202236 BXGD004086 Triglycerides measurement
C0206139 BXGD004159 Lichen Planus, Oral Skin and Connective Tissue Diseases; Stomatognathic Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0236733 BXGD004822 Amphetamine-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0236804 BXGD004835 Amphetamine Addiction Chemically-Induced Disorders; Mental Disorders
C0236807 BXGD004836 Amphetamine Abuse Chemically-Induced Disorders; Mental Disorders
C0237123 BXGD004845 Alcohol or Other Drugs use
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0274861 BXGD006372 Arsenic Poisoning, Inorganic Nervous System Diseases; Chemically-Induced Disorders
C0274862 BXGD006373 Nervous System, Organic Arsenic Poisoning Nervous System Diseases; Chemically-Induced Disorders
C0311375 BXGD006883 Arsenic Poisoning Nervous System Diseases; Chemically-Induced Disorders
C0338831 BXGD007216 Manic Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0424574 BXGD008534 Duration of sleep
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0596887 BXGD009648 mathematical ability
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0599909 BXGD009678 stress related disorder
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686347 BXGD009832 Tardive Dyskinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0751851 BXGD010610 Arsenic Encephalopathy Nervous System Diseases; Chemically-Induced Disorders
C0751852 BXGD010611 Arsenic Induced Polyneuropathy Nervous System Diseases; Chemically-Induced Disorders
C0855112 BXGD011074 Diffuse large B-cell lymphoma refractory Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0865800 BXGD011295 asthma with copd
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1305855 BXGD012348 Body mass index
C1318973 BXGD012407 Staphylococcus aureus infection Infections
C1332201 BXGD012502 Adult Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1445957 BXGD013081 Serum total cholesterol measurement
C1527358 BXGD013279 Phototoxicity Skin and Connective Tissue Diseases
C1739108 BXGD013730 Latent Autoimmune Diabetes in Adults Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1879321 BXGD016572 Acute Myeloid Leukemia (AML-M2) Neoplasms
C2939186 BXGD018176 Disturbance in mood Mental Disorders
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3714760 BXGD019432 Drug-induced tardive dyskinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Chemically-Induced Disorders
C3840565 BXGD019797 Autoimmune thyroid disease (AITD)
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4551463 BXGD023300 Colon adenoma Digestive System Diseases; Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000202 Papaverine 339.39
BXGC0000204 Theophylline 180.16
BXGC0000205 Theobromine 180.16
BXGC0000436 Glycerol 92.09
BXGC0000988 3' 5'-cyclic AMP 329.21
BXGC0001502 Caffeine 194.19
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0002692 Arsenic 77.95
BXGC0003117 Phosphodiesterase 289.29
BXGC0003776 Flavones 222.24
BXGC0005310 Moracin M 242.23
BXGC0005313 Moracin C 310.34
BXGC0006306 Myricetin 318.24
BXGC0009047 3-Methoxynobiletin 432.42
BXGC0024261 Adenosine Phosphate 347.06
BXGC0029695 Tocladesine 363.01
BXGC0029783 Benzoylenurea 162.04
BXGC0034941 Combretastatin A4 316.13
BXGC0038499 Xanthine 152.03
BXGC0043908 3-Methylxanthine 166.05
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein