acompound

Showing entry for Urea

General Compound Information
BXGC Id	BXGC0005881
Compound Name	Urea
Structure
Formula	CH4N2O
InchiKey	XSQUKJJJFZCRTK-UHFFFAOYSA-N
SMILES	NC(N)=O
Inchi	InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)
IUPAC	urea
Molecular Weight	60.06
Pubchem Id	1176
Chembl Id	CHEMBL985

Targets of Information Source

DrugBank

DB03904

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
P05089	BXGT006310	Arginase-1	reviewed	Enzyme	ARG1	approved; investigational	-
P00918	BXGT005690	Carbonic anhydrase 2	reviewed	-	CA2	approved; investigational	-
P35222	BXGT009799	Catenin beta-1	reviewed	-	CTNNB1	approved; investigational	-
Q8XB74	BXGT019046	Protein-methionine-sulfoxide reductase catalytic subunit MsrP	reviewed	-	msrP	approved; investigational	-
P00378	BXGT005523	Dihydrofolate reductase	reviewed	-	DHFR	approved; investigational	activator

PDB

URE

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
P00918	BXGT005690	Carbonic anhydrase 2	reviewed	CA2	-	-	-	-	-
P0ABQ4	BXGT007239	Dihydrofolate reductase	reviewed	folA	-	-	-	-	-
P05674	BXGT006377	Structural polyprotein	reviewed		-	-	-	-	-
P07824	BXGT006682	Arginase-1	reviewed	Arg1	-	-	-	-	-
P76342	BXGT011781	Protein-methionine-sulfoxide reductase catalytic subunit MsrP	reviewed	msrP	-	-	-	-	-
P01889	BXGT005809	HLA class I histocompatibility antigen, B-7 alpha chain	reviewed	HLA-B	-	-	-	-	-
P00698	BXGT005617	Lysozyme C	reviewed	LYZ	-	-	-	-	-
P00648	BXGT005607	Ribonuclease	reviewed		-	-	-	-	-
A0T1L9	BXGT000971	Moesin	unreviewed		-	-	-	-	-
P14739	BXGT008044	Uracil-DNA glycosylase inhibitor	reviewed	UGI	-	-	-	-	-
P01308	BXGT005749	Insulin	reviewed	INS	-	-	-	-	-
A7LBW5	BXGT001563	NblA	unreviewed		-	-	-	-	-
P02879	BXGT005982	Ricin	reviewed		-	-	-	-	-
P73600	BXGT011725	Sll1785 protein	unreviewed	sll1785	-	-	-	-	-
P0AC02	BXGT007247	Outer membrane protein assembly factor BamD	reviewed	bamD	-	-	-	-	-
Q02248	BXGT012646	Catenin beta-1	reviewed	Ctnnb1	-	-	-	-	-
P17707	BXGT008331	S-adenosylmethionine decarboxylase proenzyme	reviewed	AMD1	Enzyme	-	-	-	-
Q46509	BXGT014646	Aldehyde oxidoreductase	reviewed	mop	-	-	-	-	-
P00800	BXGT005661	Thermolysin	reviewed	npr	-	-	-	-	-
P03367	BXGT006057	Gag-Pol polyprotein	reviewed	gag-pol	-	-	-	-	-
Q2PBR5	BXGT014153	Polyprotein	unreviewed		-	-	-	-	-
Q6N0W2	BXGT016382	Possible ABC transporter binding protein component	unreviewed	RPA4648	-	-	-	-	-
P56817	BXGT011200	Beta-secretase 1	reviewed	BACE1	Enzyme	-	-	-	-
B6JPK4	BXGT002206	Methyl-accepting chemotaxis transmembrane sensory protein (MCP-like protein)	unreviewed	tlpB	-	-	-	-	-
Q6F6A2	BXGT016275	Deoxyribodipyrimidine photo-lyase	reviewed	PHR	-	-	-	-	-
Q6CP22	BXGT016224	KLLA0E08119p	unreviewed	KLLA0_E08119g	-	-	-	-	-
G1EUI6	BXGT003425	Lectin	unreviewed	pelA	-	-	-	-	-
Q9HYN5	BXGT020666	Fucose-binding lectin PA-IIL	unreviewed	lecB	-	-	-	-	-
P05091	BXGT006312	Aldehyde dehydrogenase, mitochondrial	reviewed	ALDH2	Enzyme	-	-	-	-
Q9AM02	BXGT020078	C-phycocyanin alpha subunit	unreviewed		-	-	-	-	-
Q71RW8	BXGT016703	C-phycocyanin beta subunit	unreviewed		-	-	-	-	-
P02756	BXGT005947	Beta-lactoglobulin	reviewed	LGB	-	-	-	-	-
Q8TQ92	BXGT018838	Rubredoxin	unreviewed	MA_1659	-	-	-	-	-
P75682	BXGT011751	Putative 2-dehydro-3-deoxy-D-gluconate aldolase YagE	reviewed	yagE	-	-	-	-	-
P03069	BXGT006015	General control protein GCN4	reviewed	GCN4	-	-	-	-	-
Q5JIH3	BXGT015447	Hydrogenase maturation factor HypA	reviewed	hypA	-	-	-	-	-
Q91970	BXGT019287	CT protein	unreviewed	CT	-	-	-	-	-
P01903	BXGT005814	HLA class II histocompatibility antigen, DR alpha chain	reviewed	HLA-DRA	Immune response	-	-	-	-
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	reviewed	HLA-DRB1	Immune response	-	-	-	-
P18771	BXGT008424	Long-tail fiber proximal subunit	reviewed	34	-	-	-	-	-
A0A024B7W1	BXGT000011	Genome polyprotein	reviewed		-	-	-	-	-
O82825	BXGT005218	HspA	unreviewed	hspA	-	-	-	-	-
Q8YMJ3	BXGT019134	All4940 protein	unreviewed	all4940	-	-	-	-	-
P39138	BXGT010102	Arginase	reviewed	rocF	-	-	-	-	-
P41020	BXGT010218	Urease subunit alpha	reviewed	ureC	-	-	-	-	-

Binding DB

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM

CHEMBL

CHEMBL985

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
Q9NPD5	BXGT021151	Solute carrier organic anion transporter family member 1B3	reviewed	Transporter	SLCO1B3	Inhibition	'='	105	%
P02545	BXGT005889	Prelamin-A/C	reviewed	-	LMNA	Potency	'='	794	nM
Q03181	BXGT012701	Peroxisome proliferator-activated receptor delta	reviewed	Nuclear receptor	PPARD	Potency	-	44	nM
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	reviewed	Enzyme	NFE2L2	Potency	-	74978	nM
Q9NUW8	BXGT021219	Tyrosyl-DNA phosphodiesterase 1	reviewed	Enzyme	TDP1	Potency	'='	28183	nM
P15917	BXGT008169	Lethal factor	reviewed	-	lef	Potency	'='	31622	nM
P00352	BXGT005510	Retinal dehydrogenase 1	reviewed	Enzyme	ALDH1A1	Potency	'='	39810	nM
O95398	BXGT005378	Rap guanine nucleotide exchange factor 3	reviewed	Enzyme modulator	RAPGEF3	Potency	-	125892	nM
P83916	BXGT012025	Chromobox protein homolog 1	reviewed	Epigenetic regulator	CBX1	Potency	-	100000	nM
Q9Y6L6	BXGT022334	Solute carrier organic anion transporter family member 1B1	reviewed	Transporter	SLCO1B1	Inhibition	'='	87	%
Q9UNA4	BXGT021785	DNA polymerase iota	reviewed	-	POLI	Potency	-	89125	nM

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00038	Tea	Camellia sinensis	Teas
BXGF00142	Purslane	Portulaca oleracea	Herbs and Spices
BXGF00305	Chinese chestnut	Castanea mollissima	Nuts
BXGF05203	Chlamydomonas reinhardtii	Chlamydomonas reinhardtii	Others

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}