Showing entry for Tyrosine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0013237
Compound NameTyrosine
Structure
FormulaC9H11NO3
InchiKeyOUYCCCASQSFEME-QMMMGPOBSA-N
SMILESOC(=O)[C@H](Cc1ccc(cc1)O)N
InchiInChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1
IUPAC(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid
Molecular Weight181.07
Pubchem Id6057
Chembl IdCHEMBL925
Targets of Information Source
DrugBank DB00135
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P07101 BXGT006547 Tyrosine 3-monooxygenase reviewed - TH approved; investigational; nutraceutical binder
Q9Y2Z4 BXGT022251 Tyrosine--tRNA ligase, mitochondrial reviewed Enzyme YARS2 approved; investigational; nutraceutical -
P54577 BXGT011055 Tyrosine--tRNA ligase, cytoplasmic reviewed Enzyme YARS approved; investigational; nutraceutical -
P17735 BXGT008335 Tyrosine aminotransferase reviewed - TAT approved; investigational; nutraceutical -
PDB TYR
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P00509 BXGT005562 Aspartate aminotransferase reviewed aspC - - - - -
Q57834 BXGT015139 Tyrosine--tRNA ligase reviewed tyrS - - - - -
P15369 BXGT008112 Scytalidopepsin B reviewed - - - - -
P00952 BXGT005701 Tyrosine--tRNA ligase reviewed tyrS - - - - -
P0AGJ9 BXGT007377 Tyrosine--tRNA ligase reviewed tyrS - - - - -
P12063 BXGT007768 Tyrosine--tRNA ligase, mitochondrial reviewed cyt-18 - - - - -
P04958 BXGT006288 Tetanus toxin reviewed tetX - - - - -
P27001 BXGT009149 Phenylalanine--tRNA ligase alpha subunit reviewed pheS - - - - -
Q5SGX1 BXGT015662 Phenylalanine--tRNA ligase beta subunit reviewed pheT - - - - -
P01180 BXGT005741 Vasopressin-neurophysin 2-copeptin reviewed AVP - - - - -
P32178 BXGT009607 Chorismate mutase reviewed ARO7 - - - - -
O29482 BXGT004342 Tyrosine--tRNA ligase reviewed tyrS - - - - -
O58739 BXGT004810 Tyrosine--tRNA ligase reviewed tyrS - - - - -
P01175 BXGT005740 Oxytocin-neurophysin 1 reviewed OXT - - - - -
P43902 BXGT010420 T-protein reviewed tyrA - - - - -
P00777 BXGT005650 Streptogrisin-B reviewed sprB - - - - -
P96896 BXGT012192 Leucine-responsive regulatory protein unreviewed lrp - - - - -
P00800 BXGT005661 Thermolysin reviewed npr - - - - -
Q8A3I4 BXGT017806 Alpha-L-fucosidase unreviewed BT_2970 - - - - -
O53512 BXGT004702 Phospho-2-dehydro-3-deoxyheptonate aldolase AroG reviewed aroG - - - 39000 -
O53512 BXGT004702 Phospho-2-dehydro-3-deoxyheptonate aldolase AroG reviewed aroG - - - - -
P04825 BXGT006271 Aminopeptidase N reviewed pepN - - - - -
P00730 BXGT005629 Carboxypeptidase A1 reviewed CPA1 - - - - -
O67636 BXGT005001 Prephenate dehydrogenase unreviewed tyrA - - - - -
Q834W6 BXGT017459 Hydrophobic dipeptide epimerase reviewed EF_1511 - - - - -
Q8GMG0 BXGT018165 MIO-dependent tyrosine 2,3-aminomutase reviewed - - - - -
B7GNN8 BXGT002245 Alpha-1,3/4-fucosidase, putative unreviewed Blon_2336 - - - - -
O29524 BXGT004343 Ribosomal RNA small subunit methyltransferase Nep1 reviewed nep1 - - - - -
Q9WYH8 BXGT021987 Phospho-2-dehydro-3-deoxyheptonate aldolase reviewed aroF - - - - -
Q8IAR7 BXGT018237 Tyrosine--tRNA ligase unreviewed PF3D7_0807900 - - - - -
V5YM14 BXGT022598 Dipeptidyl aminopeptidase BII reviewed dapb2 - - - - -
G0WVH3 BXGT003415 ApnAA1 unreviewed apnA - - - - -
Q9K169 BXGT020867 Phospho-2-dehydro-3-deoxyheptonate aldolase unreviewed aroG - - - 22000 -
Q6B856 BXGT016212 Tubulin beta-2B chain reviewed TUBB2B - - - - -
P53634 BXGT011007 Dipeptidyl peptidase 1 reviewed CTSC Enzyme - - - -
A0A0H2UKY9 BXGT000222 Tyrosine--tRNA ligase unreviewed tyrS - - - - -
B2ZB02 BXGT002020 Tyrosinase unreviewed - - - - -
P42738 BXGT010336 Chorismate mutase 1, chloroplastic reviewed CM1 - - - - -
P54577 BXGT011055 Tyrosine--tRNA ligase, cytoplasmic reviewed YARS1 Enzyme - - - -
Q9HXC7 BXGT020646 Protein tyrosine phosphatase TpbA unreviewed tpbA - - - - -
P00952 BXGT005701 Tyrosine--tRNA ligase reviewed tyrS - - - 11600 -
Q92MG1 BXGT019425 Putative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase unreviewed tyrC - - - - -
Q9K169 BXGT020867 Phospho-2-dehydro-3-deoxyheptonate aldolase unreviewed aroG - - - - -
Q5BCM1 BXGT015297 Tyrosine--tRNA ligase unreviewed ANIA_01709 - - - - -
C5P455 BXGT002524 Tyrosine--tRNA ligase unreviewed CPC735_063460 - - - - -
D9QA55 BXGT003038 Arginine repressor unreviewed argR - - - - -
P17643 BXGT008323 5,6-dihydroxyindole-2-carboxylic acid oxidase reviewed TYRP1 Enzyme - - - -
I1MYY4 BXGT003653 Prephenate dehydrogenase 1 unreviewed PDH1 - - 5900000 - -
I1MYY4 BXGT003653 Prephenate dehydrogenase 1 unreviewed PDH1 - - 4700000 - -
Q9I000 BXGT020684 Phospho-2-dehydro-3-deoxyheptonate aldolase unreviewed PA2843 - - - 23000 -
Q81P63 BXGT017354 Prephenate dehydrogenase unreviewed tyrA - - - - -
Q9RVZ5 BXGT023707 Aminopeptidase N unreviewed DR_0875 - - - - -
P00888 BXGT023719 Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive reviewed aroF - - - - -
B0VML7 BXGT001870 Tyrosine--tRNA ligase unreviewed tyrS - - - - -
O82415 BXGT005216 Tyrosine/dopa decarboxylase reviewed TYDC - - - - -
A0A0H2ZBG1 BXGT000348 PvdP unreviewed pvdP - - - - -
B4FNK8 BXGT024190 Chorismate mutase 1, chloroplastic reviewed CM1 - - - - -
Q18A65 BXGT024203 ABC-type transport system, sugar-family extracellular solute-binding protein unreviewed CD630_08730 - - - 94000 -
A0A1S9DK56 BXGT024542 Tyrosinase unreviewed OAory_01107480 - - - - -
P39643 BXGT024733 Transaminase BacF reviewed bacF - - - - -
B4RP13 BXGT025129 Tyrosine--tRNA ligase reviewed tyrS - - - - -
Q16769 BXGT013665 Glutaminyl-peptide cyclotransferase reviewed QPCT Enzyme - - - -
A0A4Y7X244 BXGT026014 Sodium-dependent transporter unreviewed E2L07_01100 - - - - -
A0A0J9X1X3 BXGT026057 L-lysine oxidase unreviewed - - - - -
Binding DB 18129
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT018567 Tubulin--tyrosine ligase reviewed TTL 25000 - - -
CHEMBL CHEMBL925
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Kcat '=' 12 10'6/s
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Kcat/Km '=' 37 /mM/s
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ka '=' 0 uM
P07451 BXGT006627 Carbonic anhydrase 3 reviewed - CA3 Ka '=' 34 uM
Q3I4V7 BXGT014421 Carbonic anhydrase unreviewed - CAN2 KA '=' 29 uM
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 Ka '=' 0 uM
P23280 BXGT008844 Carbonic anhydrase 6 reviewed - CA6 KA '=' 9 uM
P40881 BXGT010205 Carbonic anhydrase reviewed - Kcat '=' 10 10'4/s
Q4WAW7 BXGT014911 Tryprostatin B synthase reviewed - ftmPT1 Activity - - -
Q16790 BXGT013670 Carbonic anhydrase 9 reviewed - CA9 KA '=' 25 uM
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 Kcat '=' 13 10'5/s
Q91Y77 BXGT019323 Monocarboxylate transporter 10 reviewed - Slc16a10 Activity '=' 80 %
Q99N23 BXGT019994 Carbonic anhydrase 15 reviewed - Ca15 KA '=' 8 uM
P53615 BXGT011003 Carbonic anhydrase reviewed - NCE103 Ka '=' 85 uM
Q50565 BXGT014936 Carbonic anhydrase unreviewed - MTH_1582 Ka '=' 10 uM
Q9Y2D0 BXGT022229 Carbonic anhydrase 5B, mitochondrial reviewed - CA5B KA '=' 0 uM
P19145 BXGT008463 General amino-acid permease GAP1 reviewed - GAP1 Activity - - -
Q9ULX7 BXGT021769 Carbonic anhydrase 14 reviewed - CA14 KA '=' 21 uM
Q6FTL6 BXGT016286 Carbonic anhydrase unreviewed - NCE103 Ka '=' 9 uM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Kcat '=' 7 /s
P43166 BXGT010364 Carbonic anhydrase 7 reviewed - CA7 KA '=' 20 uM
Q5AJ71 BXGT015288 Carbonic anhydrase reviewed - NCE103 KA '=' 46 uM
O43570 BXGT004601 Carbonic anhydrase 12 reviewed - CA12 KA '=' 25 uM
P40881 BXGT010205 Carbonic anhydrase reviewed - KA '=' 24 uM
P40881 BXGT010205 Carbonic anhydrase reviewed - Activity - - -
Q05BR4 BXGT012851 SLC16A10 protein unreviewed - SLC16A10 Km '=' 636300 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Activity '=' 15637 -
P22748 BXGT008802 Carbonic anhydrase 4 reviewed - CA4 Ka '=' 25 uM
P35218 BXGT009796 Carbonic anhydrase 5A, mitochondrial reviewed - CA5A KA '=' 2 uM
Q8K1P8 BXGT018393 Monocarboxylate transporter 8 reviewed - SLC16A2 Activity '=' 0 %
Q91Y77 BXGT019323 Monocarboxylate transporter 10 reviewed - Slc16a10 Km '=' 2590000 nM
P05164 BXGT006333 Myeloperoxidase reviewed Enzyme MPO IC50 - - -
P41240 BXGT010242 Tyrosine-protein kinase CSK reviewed Kinase CSK Activity - - -
Q8K1P8 BXGT018393 Monocarboxylate transporter 8 reviewed - SLC16A2 Activity - - -
Q91Y77 BXGT019323 Monocarboxylate transporter 10 reviewed - Slc16a10 Activity '=' 70 %
Q01650 BXGT012603 Large neutral amino acids transporter small subunit 1 reviewed Transporter SLC7A5 Inhibition '=' 68 %
Q05BR4 BXGT012851 SLC16A10 protein unreviewed - SLC16A10 Activity '=' 100 %
Q8K1P8 BXGT018393 Monocarboxylate transporter 8 reviewed - SLC16A2 Activity '=' 37 %
Q01650 BXGT012603 Large neutral amino acids transporter small subunit 1 reviewed Transporter SLC7A5 IC50 '=' 68000 nM
Q9Z1J7 BXGT022405 Amino acid transporter unreviewed - Slc1a5 Inhibition '>=' 25 %
Q91Y77 BXGT019323 Monocarboxylate transporter 10 reviewed - Slc16a10 Activity - - -
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Km '=' 210000 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Km '=' 250000 nM
Q01650 BXGT012603 Large neutral amino acids transporter small subunit 1 reviewed Transporter SLC7A5 Activity '=' 96 %
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 Activity - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Activity - - -
Q01650 BXGT012603 Large neutral amino acids transporter small subunit 1 reviewed Transporter SLC7A5 Activity '=' 2 fmol/min
Q4CVY4 BXGT026093 Carbonic anhydrase-like protein, putative unreviewed - Tc00.1047053509597.20 KA '=' 4 uM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00008 Garlic Allium sativum Herbs and Spices
BXGF00027 Chinese mustard Brassica juncea Vegetables
BXGF00204 Common grape Vitis vinifera Fruits
BXGF00212 Chinese chives Allium tuberosum Herbs and Spices
BXGF00337 Ginkgo nuts Ginkgo biloba Herbs and Spices
BXGF00380 White mustard Sinapis alba Herbs and Spices
BXGF00979 Cistanche deserticola Cistanche deserticola Medicinal Plant
BXGF01780 Selaginella tamariscina Selaginella tamariscina Medicinal Plant
BXGF01972 Ficus simplicissima Ficus simplicissima Medicinal Plant
BXGF02054 Shorea uliginosa Shorea uliginosa Others
BXGF02275 Trichosanthes kirilowii maxim Trichosanthes kirilowii maxim Others
BXGF02290 Sonchus microcarpus Sonchus microcarpus Others
BXGF02526 Santalum album Santalum album Medicinal Plant
BXGF02815 Pinellia ternata Pinellia ternata Medicinal Plant
BXGF03490 Atractylodes macrocephala koidz Atractylodes macrocephala koidz Others
BXGF03614 Ageratum conyzoides Ageratum conyzoides Medicinal Plant
BXGF04643 Selaginella pulvinata Selaginella pulvinata Medicinal Plant
BXGF05178 Lilium hansonii Lilium hansonii Medicinal Plant
BXGF05203 Chlamydomonas reinhardtii Chlamydomonas reinhardtii Others
BXGF05330 Arum ternatum thunb Arum ternatum thunb Others
BXGF06126 Strychnos diplotricha Strychnos diplotricha Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease