Showing entry for Carbonic anhydrase 12


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004601
Protein NameCarbonic anhydrase 12
Uniport IdO43570
GeneCA12
Gene Id771
DomainCarb_anhydrase
Pfam PF00194  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.2 Energy metabolism hsa00910 Nitrogen metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0015701 bicarbonate transport
Biological Process GO:0055064 chloride ion homeostasis
Biological Process GO:0006730 one-carbon metabolic process
molecular function GO:0004089 carbonate dehydratase activity
molecular function GO:0016836 hydro-lyase activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0016021 integral component of membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1475029 Reversible hydration of carbon dioxide
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004114 BXGD000255 Astrocytoma Neoplasms
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011175 BXGD000701 Dehydration Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0011334 BXGD000716 Dental caries Stomatognathic Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0017601 BXGD001125 Glaucoma Eye Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017654 BXGD001136 Glomerular Filtration Rate
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0020461 BXGD001395 Hyperkalemia Nutritional and Metabolic Diseases
C0020625 BXGD001451 Hyponatremia Nutritional and Metabolic Diseases
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0030779 BXGD002252 Pelger-Huet Anomaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0037036 BXGD002661 Sialorrhea Stomatognathic Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0041327 BXGD002916 Tuberculosis, Pulmonary Infections; Respiratory Tract Diseases
C0043046 BXGD003024 Wasting Syndrome Nutritional and Metabolic Diseases
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0158266 BXGD003878 Intervertebral Disc Degeneration Musculoskeletal Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0232466 BXGD004543 Feeding difficulties
C0238033 BXGD004861 Carcinoma of Male Breast Neoplasms; Skin and Connective Tissue Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242787 BXGD005195 Malignant neoplasm of male breast Neoplasms; Skin and Connective Tissue Diseases; Endocrine System Diseases
C0263992 BXGD005358 Exertional rhabdomyolysis (disorder) Musculoskeletal Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0375023 BXGD007970 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0677055 BXGD009715 CARCINOMA OF VULVA Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699949 BXGD009872 airway disease Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0740418 BXGD009994 Chronic back pain Pathological Conditions, Signs and Symptoms
C0857112 BXGD011136 Bilateral glaucoma Eye Diseases
C0857122 BXGD011138 Hyponatraemic
C1153706 BXGD011769 Endometrial adenocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1176475 BXGD011798 Ductal Carcinoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1275122 BXGD012060 Familial multiple trichoepitheliomata Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1334177 BXGD012684 Infiltrating Cervical Carcinoma
C1336076 BXGD012828 Sporadic Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1840437 BXGD014469 Isolated hyperchlorhidrosis
C1960398 BXGD016658 HER2-positive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2749757 BXGD017634 BRONCHIECTASIS WITH OR WITHOUT ELEVATED SWEAT CHLORIDE 1 Respiratory Tract Diseases
C2751324 BXGD017712 BRONCHIECTASIS WITH OR WITHOUT ELEVATED SWEAT CHLORIDE 3 Respiratory Tract Diseases
C2751666 BXGD017732 BRONCHIECTASIS WITH OR WITHOUT ELEVATED SWEAT CHLORIDE 2 Respiratory Tract Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3160718 BXGD018468 PARKINSON DISEASE, LATE-ONSET
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4733095 BXGD023910 HER2-negative breast cancer
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000057 3,4-Dimethoxybenzoic acid 182.17
BXGC0000077 p-Coumaric acid ethyl ester 192.21
BXGC0000251 Syringic acid 198.17
BXGC0000286 L-DOPA 197.19
BXGC0000314 Isorhamnetin 316.26
BXGC0000340 Kaempferol 286.24
BXGC0000363 Galangin 270.24
BXGC0000368 Gallic acid 170.12
BXGC0000383 (S)-Naringenin 272.25
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0000500 2,4-Dihydroxybenzoic acid 154.12
BXGC0000502 Gentisic acid 154.12
BXGC0000503 2,6-Dihydroxybenzoic acid 154.12
BXGC0000505 Protocatechuic acid 154.12
BXGC0000506 3,5-Dihydroxybenzoic acid 154.12
BXGC0000511 1,4-Dimethoxybenzene 138.16
BXGC0000528 Salicylic acid 138.12
BXGC0000530 Hydroquinone 110.11
BXGC0000536 Phenol 94.11
BXGC0000578 Herniarin 176.17
BXGC0000681 Umbelliferone 162.14
BXGC0001002 1,2-Benzenediol 110.11
BXGC0001623 L-Tryptophan 204.23
BXGC0001767 (E)-Resveratrol 228.25
BXGC0001789 Silibinin 482.44
BXGC0001857 Caffeic acid 180.16
BXGC0001868 Catechin 290.27
BXGC0001886 trans-o-Coumaric acid 164.16
BXGC0001889 p-Coumaric acid 164.16
BXGC0001899 Daidzein 254.24
BXGC0001962 Hesperetin 302.28
BXGC0002052 Aesculetin 178.14
BXGC0002390 Spermine 202.34
BXGC0003214 L-(-)-Phenylalanine 165.19
BXGC0003221 Xanthyletin 228.24
BXGC0003281 Isoscopoletin 192.17
BXGC0003705 Chloride 35.45
BXGC0003776 Flavones 222.24
BXGC0003951 Kaempferol 3-(p-coumaroyl-glucoside) 594.52
BXGC0004139 Sperminidine 145.25
BXGC0004277 Acetic acid 60.05
BXGC0004378 3-Hydroxyflavone 238.24
BXGC0004559 1,3-Benzenediol 110.11
BXGC0004654 1,2-Dimethoxybenzene 138.16
BXGC0004710 3-Hydroxybenzoic acid 138.12
BXGC0004711 4-Hydroxybenzoic acid 138.12
BXGC0004712 Methylparaben 152.15
BXGC0004713 Ethylparaben 166.17
BXGC0004907 p-Hydroxyphenethyl trans-ferulate 314.33
BXGC0005683 Quercetin 302.24
BXGC0005702 2H-1-Benzopyran-2-one 146.15
BXGC0005852 Xanthoxyletin 258.27
BXGC0005867 Serotonin 176.22
BXGC0005871 Dopamine 153.18
BXGC0005919 Biochanin A 284.27
BXGC0006193 Ellagic acid 302.19
BXGC0006195 Fraxidin 222.19
BXGC0006198 Citric acid 192.12
BXGC0006291 Scopoletin 192.17
BXGC0006366 trans-Ferulic acid 194.18
BXGC0006635 Luteolin 286.24
BXGC0008167 Chrysin 254.24
BXGC0008753 Isoquercitrin 464.38
BXGC0008824 Astragalin 448.38
BXGC0012243 Ukonan D 151.16
BXGC0013237 Tyrosine 181.07
BXGC0013582 Curcumin 368.13
BXGC0013854 Histamine 111.08
BXGC0015497 D-phenylalanine 165.08
BXGC0015574 5,7,8-Trimethoxycoumarin 236.07
BXGC0015760 Puerarin 416.11
BXGC0016154 Quercetin-3-O-Rhamnoside 448.1
BXGC0017965 4-Hydroxycoumarins 162.03
BXGC0018442 Lithospermic Acid 538.11
BXGC0018779 5,10-Dimethoxy-2,2-Dimethylpyrano[3,2-G]Chromen-8-One 288.1
BXGC0019091 D-Tryptophan 204.09
BXGC0019159 4-Prop-2-Enoxychromen-2-One 202.06
BXGC0020412 Methyl Protocatechuate 168.04
BXGC0021053 6-Hydroxycoumarin 162.03
BXGC0021234 Quinazolinone 146.05
BXGC0022777 Murralongin 258.09
BXGC0023605 2-Methyl-1,1-Dioxo-1,2-Benzothiazol-3-One 197.01
BXGC0023718 D-Histidine 155.07
BXGC0024810 curcumin 368.13
BXGC0027112 Benzyl (E)-P-Coumarate 254.09
BXGC0028113 Fraxine 370.09
BXGC0028840 Kaempferol-3-O-(2'',6''-Di-E-P-Coumaroyl)-Beta-Glucopyranoside 740.17
BXGC0029783 Benzoylenurea 162.04
BXGC0030123 Ethyl 3,4-Dihydroxybenzoate 182.06
BXGC0030928 Avicennol 342.15
BXGC0031608 Histidine 155.07
BXGC0032021 (+)-Calanolide B 370.18
BXGC0032542 Fraxidin Methyl Ether 236.07
BXGC0033389 Zinc;1-Oxidopyridine-2-Thione 126
BXGC0033781 Methyl P-Hydroxycinnamate 178.06
BXGC0034208 3-Aminophenol 109.05
BXGC0035476 3-Hydroxycoumarin 162.03
BXGC0035699 3,4,4'-Tri-O-methylellagic acid 344.05
BXGC0036732 5-[2-(4-Hydroxyphenyl)Ethenyl]Benzene-1,3-Diol 228.08
BXGC0038724 Benzyl Ferulate 284.1
BXGC0038903 Alloxanthoxyletin 258.09
BXGC0039476 Eriodictyol 288.06
BXGC0041110 Pentane-1,5-Diamine 102.12
BXGC0043125 Taxifolin 304.06
BXGC0043374 Salvianolic Acid A 494.12
BXGC0046948 5-Methoxy-2,2-Dimethyl-6-[(1E)-3-Methylbuta-1,3-Dienyl]Pyrano[2,3-H]Chromen-8-One 324.14
BXGC0047169 Hymecromone 176.05
BXGC0047871 7-Hydroxyflavone 238.06
BXGC0048244 1H-Quinolin-2-One 145.05
BXGC0048389 Catechin 290.08
BXGC0049447 acetate 59.01
BXGC0049449 2,6-Dimethoxybenzoic Acid 182.06
BXGC0049633 4-Aminophenol 109.05
BXGC0052888 Kaempferol-3-O-(3'',4\\"-Diacetyl-2\\",6\\"-Di-E-P-Coumaroyl)-Glucoside 824.2
BXGC0052890 7-Hydroxy-8-Methoxychromen-2-One 192.04
BXGC0053235 Fraxetin 208.04
BXGC0053251 Methyl 2,4-Dihydroxybenzoate 168.04
BXGC0053401 Scopolin 354.1
BXGC0053602 Salvianolic acid B 720.17
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein