Showing entry for Tyrosine--tRNA ligase, cytoplasmic


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011055
Protein NameTyrosine--tRNA ligase, cytoplasmic
Uniport IdP54577
GeneYARS1
Gene Id8565
DomaintRNA-synt_1b; tRNA_bind
Pfam PF00579   PF01588  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.2 Translation hsa00970 Aminoacyl-tRNA biosynthesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006915 apoptotic process
Biological Process GO:0006418 tRNA aminoacylation for protein translation
Biological Process GO:0006437 tyrosyl-tRNA aminoacylation
molecular function GO:0005524 ATP binding
molecular function GO:0005153 interleukin-8 receptor binding
molecular function GO:0003723 RNA binding
molecular function GO:0000049 tRNA binding
molecular function GO:0004831 tyrosine-tRNA ligase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005615 extracellular space
cellular component GO:0016604 nuclear body
Reactome
Pathway Id Pathway Name
R-HSA-379716 Cytosolic tRNA aminoacylation
R-HSA-379724 tRNA Aminoacylation
R-HSA-392499 Metabolism of proteins
R-HSA-72766 Translation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007959 BXGD000507 Charcot-Marie-Tooth Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0016506 BXGD001062 Foot Deformities Musculoskeletal Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0153594 BXGD003669 Malignant neoplasm of testis Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0427065 BXGD008604 Distal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0585362 BXGD009592 Squamous cell carcinoma of mouth Digestive System Diseases; Neoplasms; Stomatognathic Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0855197 BXGD011079 Malignant Testicular Germ Cell Tumor Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C1698196 BXGD013513 Muscle Weakness Upper Limb Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1842237 BXGD014507 Charcot-Marie-Tooth Disease, Dominant Intermediate C Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1847584 BXGD014876 Distal sensory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1848736 BXGD014970 Distal amyotrophy
C1854454 BXGD015404 Axonal regeneration
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0001767 (E)-Resveratrol 228.25
BXGC0002591 Potassium 39.1
BXGC0003705 Chloride 35.45
BXGC0013237 Tyrosine 181.07
BXGC0034035 Capsaicin 305.2
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein