Showing entry for Carbonic anhydrase 4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008802
Protein NameCarbonic anhydrase 4
Uniport IdP22748
GeneCA4
Gene Id762
DomainCarb_anhydrase
Pfam PF00194  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.2 Energy metabolism hsa00910 Nitrogen metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
5. Organismal Systems 5.5 Excretory system hsa04964 Proximal tubule bicarbonate reclamation
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0015701 bicarbonate transport
Biological Process GO:0006730 one-carbon metabolic process
molecular function GO:0004089 carbonate dehydratase activity
molecular function GO:0016836 hydro-lyase activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0031362 anchored component of external side of plasma membrane
cellular component GO:0016324 apical plasma membrane
cellular component GO:0031526 brush border membrane
cellular component GO:0009986 cell surface
cellular component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
cellular component GO:0070062 extracellular exosome
cellular component GO:0005794 Golgi apparatus
cellular component GO:0016020 membrane
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0005791 rough endoplasmic reticulum
cellular component GO:0030667 secretory granule membrane
cellular component GO:0005802 trans-Golgi network
cellular component GO:0030658 transport vesicle membrane
Reactome
Pathway Id Pathway Name
R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen
R-HSA-1247673 Erythrocytes take up oxygen and release carbon dioxide
R-HSA-1430728 Metabolism
R-HSA-1475029 Reversible hydration of carbon dioxide
R-HSA-1480926 O2/CO2 exchange in erythrocytes
R-HSA-382551 Transport of small molecules
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009398 BXGD000604 Color vision defect Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0018777 BXGD001217 Conductive hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020619 BXGD001447 Hypogonadism Endocrine System Diseases
C0022578 BXGD001557 Keratoconus Eye Diseases
C0027059 BXGD001965 Myocarditis Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028077 BXGD002069 Nyctalopia Eye Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029089 BXGD002107 Ophthalmoplegia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0266435 BXGD005668 Congenital hypoplasia of penis Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0339525 BXGD007258 Autosomal dominant retinitis pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0476397 BXGD008991 Electroretinogram abnormal
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C1833245 BXGD013906 Retinitis Pigmentosa 17 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1836926 BXGD014179 Bone spicule pigmentation of the retina
C1840077 BXGD014434 Anteverted nostril
C1849367 BXGD015046 Nasal bridge wide
C1862475 BXGD016132 Abnormality of retinal pigmentation
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C1998028 BXGD016865 Photoreceptor degeneration Eye Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021786 BXGD020779 Atypical scarring of skin Pathological Conditions, Signs and Symptoms
C4024818 BXGD021428 Progressive night blindness Eye Diseases
C4551714 BXGD023398 Rod-Cone Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000057 3,4-Dimethoxybenzoic acid 182.17
BXGC0000251 Syringic acid 198.17
BXGC0000286 L-DOPA 197.19
BXGC0000314 Isorhamnetin 316.26
BXGC0000340 Kaempferol 286.24
BXGC0000363 Galangin 270.24
BXGC0000368 Gallic acid 170.12
BXGC0000383 (S)-Naringenin 272.25
BXGC0000436 Glycerol 92.09
BXGC0000505 Protocatechuic acid 154.12
BXGC0000528 Salicylic acid 138.12
BXGC0000530 Hydroquinone 110.11
BXGC0000536 Phenol 94.11
BXGC0000578 Herniarin 176.17
BXGC0001002 1,2-Benzenediol 110.11
BXGC0001623 L-Tryptophan 204.23
BXGC0001767 (E)-Resveratrol 228.25
BXGC0001789 Silibinin 482.44
BXGC0001857 Caffeic acid 180.16
BXGC0001868 Catechin 290.27
BXGC0001886 trans-o-Coumaric acid 164.16
BXGC0001889 p-Coumaric acid 164.16
BXGC0001899 Daidzein 254.24
BXGC0001962 Hesperetin 302.28
BXGC0002018 Morin 302.24
BXGC0002071 Apigenin 270.24
BXGC0002390 Spermine 202.34
BXGC0002690 alpha-Catechin 290.27
BXGC0002698 Fluorine 19
BXGC0002722 Nitrate 62
BXGC0003214 L-(-)-Phenylalanine 165.19
BXGC0003533 Carbonate 60.01
BXGC0003705 Chloride 35.45
BXGC0003751 Cyanide 26.02
BXGC0003951 Kaempferol 3-(p-coumaroyl-glucoside) 594.52
BXGC0004139 Sperminidine 145.25
BXGC0004556 1,2,3-Benzenetriol 126.11
BXGC0004559 1,3-Benzenediol 110.11
BXGC0004654 1,2-Dimethoxybenzene 138.16
BXGC0004681 Hydrogen sulfide (H2S) 34.08
BXGC0004711 4-Hydroxybenzoic acid 138.12
BXGC0004907 p-Hydroxyphenethyl trans-ferulate 314.33
BXGC0005625 alpha-D-Glucopyranose 180.16
BXGC0005668 2-Methoxyphenol 124.14
BXGC0005683 Quercetin 302.24
BXGC0005702 2H-1-Benzopyran-2-one 146.15
BXGC0005867 Serotonin 176.22
BXGC0005871 Dopamine 153.18
BXGC0005919 Biochanin A 284.27
BXGC0006193 Ellagic acid 302.19
BXGC0006366 trans-Ferulic acid 194.18
BXGC0006635 Luteolin 286.24
BXGC0007046 Thiocyanic acid 59.09
BXGC0007519 Hydrocyanic acid 27.03
BXGC0008094 Potassium nitrate (KNO3) 101.1
BXGC0008101 Sodium nitrite 69
BXGC0008167 Chrysin 254.24
BXGC0008753 Isoquercitrin 464.38
BXGC0008824 Astragalin 448.38
BXGC0008958 Naringenin fructoside 272.26
BXGC0012243 Ukonan D 151.16
BXGC0013237 Tyrosine 181.07
BXGC0013582 Curcumin 368.13
BXGC0013854 Histamine 111.08
BXGC0014031 Isosorbide Mononitrate 191.04
BXGC0015497 D-phenylalanine 165.08
BXGC0015760 Puerarin 416.11
BXGC0015779 Anisole 108.06
BXGC0016154 Quercetin-3-O-Rhamnoside 448.1
BXGC0018442 Lithospermic Acid 538.11
BXGC0019091 D-Tryptophan 204.09
BXGC0023718 D-Histidine 155.07
BXGC0024810 curcumin 368.13
BXGC0025186 malic acid 132.01
BXGC0027112 Benzyl (E)-P-Coumarate 254.09
BXGC0028840 Kaempferol-3-O-(2'',6''-Di-E-P-Coumaroyl)-Beta-Glucopyranoside 740.17
BXGC0031384 Epinephrine 183.09
BXGC0031608 Histidine 155.07
BXGC0033389 Zinc;1-Oxidopyridine-2-Thione 126
BXGC0036732 5-[2-(4-Hydroxyphenyl)Ethenyl]Benzene-1,3-Diol 228.08
BXGC0038724 Benzyl Ferulate 284.1
BXGC0039476 Eriodictyol 288.06
BXGC0041110 Pentane-1,5-Diamine 102.12
BXGC0042204 Sodium Benzoate 121.03
BXGC0042270 acetohydroxamic acid 75.03
BXGC0043125 Taxifolin 304.06
BXGC0043374 Salvianolic Acid A 494.12
BXGC0048244 1H-Quinolin-2-One 145.05
BXGC0048389 Catechin 290.08
BXGC0049447 acetate 59.01
BXGC0049633 4-Aminophenol 109.05
BXGC0051398 Indole 117.06
BXGC0052387 Pyruvic Acid 87.01
BXGC0052888 Kaempferol-3-O-(3'',4\\"-Diacetyl-2\\",6\\"-Di-E-P-Coumaroyl)-Glucoside 824.2
BXGC0053602 Salvianolic acid B 720.17
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein