acompound

Showing entry for Quinazolinone

　　　　　　　　　　　　　　　

General Compound Information
BXGC Id	BXGC0021234
Compound Name	Quinazolinone
Structure
Formula	C8H6N2O
InchiKey	QMNUDYFKZYBWQX-UHFFFAOYSA-N
SMILES	Oc1ncnc2c1cccc2
Inchi	InChI=1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11)
IUPAC	1H-quinazolin-4-one
Molecular Weight	146.05
Pubchem Id	135408753
Chembl Id	CHEMBL266540

Targets of Information Source

DrugBank

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type

PDB

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
O15530	BXGT004177	3-phosphoinositide-dependent protein kinase 1	reviewed	PDPK1	Kinase	-	-	-	-
Q9Y233	BXGT022210	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	reviewed	PDE10A	-	910000	-	-	-
Q9H2K2	BXGT020454	Poly [ADP-ribose] polymerase tankyrase-2	reviewed	TNKS2	-	-	-	-	-

Binding DB

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT006934	Poly [ADP-ribose] polymerase 1	reviewed		PARP1	-	5888	-	-
reviewed	BXGT005275	Poly [ADP-ribose] polymerase 2	reviewed		Parp2	-	25704	-	-
reviewed	BXGT006934	Poly [ADP-ribose] polymerase 1	reviewed		PARP1	-	9500	-	-
reviewed	BXGT013670	Carbonic anhydrase 9	reviewed		CA9	15700	-	-	-
reviewed	BXGT005690	Carbonic anhydrase 2	reviewed		CA2	>500000	-	-	-
reviewed	BXGT004601	Carbonic anhydrase 12	reviewed		CA12	10460	-	-	-
reviewed	BXGT005689	Carbonic anhydrase 1	reviewed		CA1	>500000	-	-	-
reviewed	BXGT006934	Poly [ADP-ribose] polymerase 1	reviewed		PARP1	-	15800	-	-
reviewed	BXGT004177	3-phosphoinositide-dependent protein kinase 1	reviewed	Kinase	PDPK1	-	345000	-	-
reviewed	BXGT006934	Poly [ADP-ribose] polymerase 1	reviewed		PARP1	-	5750	-	-
reviewed	BXGT012432	Purine nucleoside phosphorylase	reviewed		punA	-	-	316228	-

CHEMBL

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
O43570	BXGT004601	Carbonic anhydrase 12	reviewed	-	CA12	Ki	'='	10460	nM
P00915	BXGT005689	Carbonic anhydrase 1	reviewed	-	CA1	Ki	'>'	500000	nM
Q920D2	BXGT019334	Dihydrofolate reductase	reviewed	-	Dhfr	Log 1/C	'='	3	-
P00374	BXGT005520	Dihydrofolate reductase	reviewed	Enzyme	DHFR	log(1/C)	'='	3	-
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	reviewed	-	PARP1	IC50	'='	9500	nM
Q16637	BXGT013646	Survival motor neuron protein	reviewed	Epigenetic regulator	SMN1	Potency	'='	1122	nM
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	reviewed	-	PARP1	IC50	'='	5750	nM
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	reviewed	-	PARP1	IC50	'='	15800	nM
P16050	BXGT008184	Arachidonate 15-lipoxygenase	reviewed	Enzyme	ALOX15	Potency	'='	39810	nM
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	reviewed	-	PARP1	Inhibition	'>'	60	%
Q9F4F7	BXGT020344	4'-phosphopantetheinyl transferase ffp	reviewed	-	ffp	Potency	'='	79432	nM
P00918	BXGT005690	Carbonic anhydrase 2	reviewed	-	CA2	Ki	'>'	500000	nM
P9WP01	BXGT012432	Purine nucleoside phosphorylase	reviewed	-	punA	Kd	'='	316227	nM
O15530	BXGT004177	3-phosphoinositide-dependent protein kinase 1	reviewed	Kinase	PDPK1	IC50	'='	345000	nM
O75496	BXGT005132	Geminin	reviewed	-	GMNN	Potency	-	6513	nM
Q16790	BXGT013670	Carbonic anhydrase 9	reviewed	-	CA9	Ki	'='	15700	nM

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF03377	Hydrangea chinensis	Hydrangea chinensis	Others
BXGF04978	Isatis indigotica	Isatis indigotica	Medicinal Plant
BXGF05297	Isatis tinctoria	Isatis tinctoria	Medicinal Plant
BXGF06143	Persicaria tinctoria	Persicaria tinctoria	Medicinal Plant

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}