Showing entry for 3-phosphoinositide-dependent protein kinase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004177
Protein Name3-phosphoinositide-dependent protein kinase 1
Uniport IdO15530
GenePDPK1
Gene Id5170
DomainPH_3; Pkinase
Pfam PF14593   PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.12 Drug resistance: Antineoplastic hsa01524 Platinum drug resistance
5. Organismal Systems 5.2 Endocrine system hsa03320 PPAR signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04068 FoxO signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04071 Sphingolipid signaling pathway
4. Cellular Processes 4.1 Transport and catabolism hsa04140 Autophagy - animal
3. Environmental Information Processing 3.2 Signal transduction hsa04150 mTOR signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04152 AMPK signaling pathway
4. Cellular Processes 4.2 Cell growth and death hsa04210 Apoptosis
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04510 Focal adhesion
5. Organismal Systems 5.1 Immune system hsa04660 T cell receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04664 Fc epsilon RI signaling pathway
5. Organismal Systems 5.6 Nervous system hsa04722 Neurotrophin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04910 Insulin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04919 Thyroid hormone signaling pathway
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04931 Insulin resistance
5. Organismal Systems 5.5 Excretory system hsa04960 Aldosterone-regulated sodium reabsorption
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05145 Toxoplasmosis
6. Human Diseases 6.1 Cancers: Overview hsa05205 Proteoglycans in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05213 Endometrial cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05215 Prostate cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05223 Non-small cell lung cancer
6. Human Diseases 6.1 Cancers: Overview hsa05231 Choline metabolism in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0032148 activation of protein kinase B activity
Biological Process GO:0019722 calcium-mediated signaling
Biological Process GO:0016477 cell migration
Biological Process GO:1990416 cellular response to brain-derived neurotrophic factor stimulus
Biological Process GO:0071364 cellular response to epidermal growth factor stimulus
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0007173 epidermal growth factor receptor signaling pathway
Biological Process GO:0097191 extrinsic apoptotic signaling pathway
Biological Process GO:0038095 Fc-epsilon receptor signaling pathway
Biological Process GO:0048041 focal adhesion assembly
Biological Process GO:0006972 hyperosmotic response
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0010667 negative regulation of cardiac muscle cell apoptotic process
Biological Process GO:2000352 negative regulation of endothelial cell apoptotic process
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:0006469 negative regulation of protein kinase activity
Biological Process GO:0034122 negative regulation of toll-like receptor signaling pathway
Biological Process GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0018107 peptidyl-threonine phosphorylation
Biological Process GO:0030168 platelet activation
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0043536 positive regulation of blood vessel endothelial cell migration
Biological Process GO:0010518 positive regulation of phospholipase activity
Biological Process GO:1903078 positive regulation of protein localization to plasma membrane
Biological Process GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
Biological Process GO:1903672 positive regulation of sprouting angiogenesis
Biological Process GO:1905564 positive regulation of vascular endothelial cell proliferation
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0043304 regulation of mast cell degranulation
Biological Process GO:0002223 stimulatory C-type lectin receptor signaling pathway
Biological Process GO:0031295 T cell costimulation
Biological Process GO:0050852 T cell receptor signaling pathway
Biological Process GO:0003323 type B pancreatic cell development
molecular function GO:0004676 3-phosphoinositide-dependent protein kinase activity
molecular function GO:0005524 ATP binding
molecular function GO:0005158 insulin receptor binding
molecular function GO:0016004 phospholipase activator activity
molecular function GO:0043274 phospholipase binding
molecular function GO:0019901 protein kinase binding
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0042995 cell projection
cellular component GO:0005737 cytoplasm
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0005829 cytosol
cellular component GO:0005925 focal adhesion
cellular component GO:0005634 nucleus
cellular component GO:0043204 perikaryon
cellular component GO:0005886 plasma membrane
cellular component GO:0014069 postsynaptic density
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-109582 Hemostasis
R-HSA-109704 PI3K Cascade
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-112399 IRS-mediated signalling
R-HSA-114604 GPVI-mediated activation cascade
R-HSA-114604 GPVI-mediated activation cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280218 Adaptive Immune System
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-165158 Activation of AKT2
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-194138 Signaling by VEGF
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-202403 TCR signaling
R-HSA-202424 Downstream TCR signaling
R-HSA-212436 Generic Transcription Pathway
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-2428924 IGF1R signaling cascade
R-HSA-2428928 IRS-related events triggered by IGF1R
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-354192 Integrin signaling
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-388841 Costimulation by the CD28 family
R-HSA-389356 CD28 co-stimulation
R-HSA-389357 CD28 dependent PI3K/Akt signaling
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-397795 G-protein beta:gamma signalling
R-HSA-438064 Post NMDA receptor activation events
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
R-HSA-442755 Activation of NMDA receptors and postsynaptic events
R-HSA-444257 RSK activation
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-5218921 VEGFR2 mediated cell proliferation
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-6806003 Regulation of TP53 Expression and Degradation
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-74752 Signaling by Insulin receptor
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-76009 Platelet Aggregation (Plug Formation)
R-HSA-8939211 ESR-mediated signaling
R-HSA-8939211 ESR-mediated signaling
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9009391 Extra-nuclear estrogen signaling
R-HSA-9009391 Extra-nuclear estrogen signaling
R-HSA-9607240 FLT3 Signaling
R-HSA-9634635 Estrogen-stimulated signaling through PRKCZ
R-HSA-9634635 Estrogen-stimulated signaling through PRKCZ
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0008924 BXGD000574 Cleft upper lip Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0023212 BXGD001616 Left-Sided Heart Failure Cardiovascular Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025322 BXGD001863 Premature Menopause Female Urogenital Diseases and Pregnancy Complications
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029401 BXGD002135 Osteitis Deformans Musculoskeletal Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032897 BXGD002378 Prader-Willi Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0035412 BXGD002548 Rhabdomyosarcoma Neoplasms
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0235527 BXGD004753 Heart Failure, Right-Sided Cardiovascular Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280321 BXGD006739 Squamous cell carcinoma of the hypopharynx
C0280324 BXGD006740 Laryngeal Squamous Cell Carcinoma Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0496956 BXGD009052 Neoplasm of uncertain or unknown behavior of breast Neoplasms; Skin and Connective Tissue Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0858252 BXGD011172 Breast adenocarcinoma Neoplasms; Skin and Connective Tissue Diseases
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332201 BXGD012502 Adult Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1512127 BXGD013185 HER2 gene amplification
C1608408 BXGD013434 Malignant transformation
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1854181 BXGD015387 FIBROMATOSIS, GINGIVAL, 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C1959583 BXGD016637 Myocardial Failure Cardiovascular Diseases
C1961112 BXGD016674 Heart Decompensation Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3642347 BXGD019246 Basal-Like Breast Carcinoma
C4321245 BXGD022744 Cleft lip or lips
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
C4721414 BXGD023738 Mantle cell lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0000655 Harmalol 200.24
BXGC0000933 (-)-Arctigenin 372.41
BXGC0001544 Harmaline 214.26
BXGC0001545 Harmine 212.25
BXGC0001940 Daphnetin 178.14
BXGC0002071 Apigenin 270.24
BXGC0002588 Magnesium 24.31
BXGC0002605 Adenosine 267.24
BXGC0003705 Chloride 35.45
BXGC0003981 2,6-Diaminopurine 150.14
BXGC0005624 Genistein 270.24
BXGC0005683 Quercetin 302.24
BXGC0005980 Isoxanthohumol 354.4
BXGC0007014 Harman 182.22
BXGC0007029 Emodin 270.24
BXGC0007052 Olomoucine 298.34
BXGC0008873 Xanthohumol 354.4
BXGC0012344 Yuanhuadine 586.28
BXGC0012352 Chelerythrine 348.12
BXGC0012706 4-hydroxy-5-nitrophenyl acetic acid 197.03
BXGC0013582 Curcumin 368.13
BXGC0016254 Dehydroabietic Acid 300.21
BXGC0020911 Debromohymenialdisine 245.09
BXGC0021234 Quinazolinone 146.05
BXGC0023872 Adenine 135.05
BXGC0024554 D-luciferin 280
BXGC0034256 Rottlerin 516.18
BXGC0042870 Piceatannol 244.07
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0046919 debromohymenialdisine 245.09
BXGC0047692 Gefitinib 446.15
BXGC0051873 Sl-0101 516.13
BXGC0051995 Wedelolactone 314.04
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein