Showing entry for Lysosomal alpha-mannosidase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT003944
Protein NameLysosomal alpha-mannosidase
Uniport IdO00754
GeneMAN2B1
Gene Id4125
DomainAlpha-mann_mid; Glyco_hydro38C2; Glyco_hydro_38C; Glyco_hydro_38N
Pfam PF09261   PF17677   PF07748   PF01074  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.7 Glycan biosynthesis and metabolism hsa00511 Other glycan degradation
4. Cellular Processes 4.1 Transport and catabolism hsa04142 Lysosome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006464 cellular protein modification process
Biological Process GO:0006013 mannose metabolic process
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0009313 oligosaccharide catabolic process
Biological Process GO:0006517 protein deglycosylation
molecular function GO:0004559 alpha-mannosidase activity
molecular function GO:0030246 carbohydrate binding
molecular function GO:0046872 metal ion binding
cellular component GO:0035578 azurophil granule lumen
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0043202 lysosomal lumen
cellular component GO:0005774 vacuolar membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-6798695 Neutrophil degranulation
R-HSA-71387 Metabolism of carbohydrates
R-HSA-8853383 Lysosomal oligosaccharide catabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0017639 BXGD001133 Gliosis Pathological Conditions, Signs and Symptoms
C0017661 BXGD001139 IGA Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0017921 BXGD001152 Glycogen storage disease type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019294 BXGD001314 Hernia, Inguinal Pathological Conditions, Signs and Symptoms
C0020555 BXGD001431 Hypertrichosis Skin and Connective Tissue Diseases
C0024421 BXGD001770 Macroglossia Stomatognathic Diseases
C0024748 BXGD001800 alpha-Mannosidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0034935 BXGD002497 Babinski Reflex
C0035304 BXGD002528 Retinal Degeneration Eye Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0038016 BXGD002727 Spondylolisthesis Musculoskeletal Diseases
C0085078 BXGD003118 Lysosomal Storage Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0086795 BXGD003311 Pfaundler-Hurler Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152421 BXGD003586 Macrotia
C0158731 BXGD003902 Congenital pectus carinatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0221354 BXGD004446 Frontal bossing Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0376480 BXGD007998 Gingival Overgrowth Stomatognathic Diseases
C0399526 BXGD008251 Class III malocclusion Stomatognathic Diseases
C0432072 BXGD008718 Dysmorphic features
C0456070 BXGD008863 Growth delay
C0557874 BXGD009444 Global developmental delay
C0678230 BXGD009750 Congenital Epicanthus
C0740279 BXGD009973 Cerebellar atrophy
C0750937 BXGD010259 Ataxia, Appendicular Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751837 BXGD010604 Gait Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1257960 BXGD011817 Mannosidase Deficiency Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1277241 BXGD012110 Delayed myelination Mental Disorders
C1836855 BXGD014170 Vacuolated lymphocytes
C1837402 BXGD014228 Flat occiput
C1837458 BXGD014233 Impaired smooth pursuit
C1842366 BXGD014512 Low anterior hairline
C1842876 BXGD014542 Depressed nasal ridge
C1844383 BXGD014628 Recurrent bacterial infection Infections
C1844813 BXGD014679 Widely spaced teeth
C1845847 BXGD014760 Coarse facial features Pathological Conditions, Signs and Symptoms
C1849089 BXGD015004 Broad forehead
C1853242 BXGD015322 Midface retrusion
C1853487 BXGD015340 Thick eyebrow
C1855114 BXGD015460 Methylmalonic Aciduria due to Methylmalonyl-CoA Mutase Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1855418 BXGD015495 Thoracolumbar kyphosis
C1858085 BXGD015770 Malar flattening
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1858452 BXGD015796 Thickened calvaria
C1859461 BXGD015895 Femoral bowing Musculoskeletal Diseases
C1864853 BXGD016261 Increased vertebral height
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4024919 BXGD021473 Spinocerebellar tract disease in lower limbs
C4025763 BXGD021783 Abnormality of the rib cage
C4048270 BXGD021897 Decreased antibody level in blood
C4317149 BXGD022731 Vacuolated Lymphocyte Count
C4553743 BXGD023548 Spasticity, CTCAE
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0012481 (2R,3R,4S)-2-(((R)-2-Hydroxy-1-Phenylethylamino)Methyl)Pyrrolidine-3,4-Diol 252.15
BXGC0030236 Deoxymannojirimycin 163.08
BXGC0032319 L-Ido-1-Deoxynojirimycin 163.08
BXGC0041132 Duvoglustat 163.08
BXGC0049562 L-1-Deoxynojirimycin 163.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein